Evaluating platelet activation in patients with heart support devices

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study focuses on patients with end-stage heart failure who are either candidates for or have received a mechanical circulatory support device, such as a Ventricular Assist Device (VAD). It aims to assess the patients' haemostatic and coagulation profiles, particularly platelet function, using innovative tests like the Platelet Activity State (PAS) assay and the Thrombin Generation Test (TGT). Measurements will be taken at various time points, including before device implantation, during hospitalization, and throughout long-term follow-up, to understand the dynamics of platelet function and its relation to thromboembolic and hemorrhagic complications. The findings may help identify therapeutic targets for improving patient outcomes.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* All consenting patients candidates for short-term (Impella, ECMO) or durable (LVAD) mechanical circulatory support device implantation
* All consenting patients that are implanted with short-term (Impella, ECMO) or durable (LVAD) mechanical circulatory support device

Exclusion Criteria:

\- Patients \< 18-years old

Where it's running

• San Raffaele Scientifc Institute - Cardiothoracic Intensive Care Unit
  Milan, Mi, Italy Recruiting

Study contacts

• Principal investigator: Filippo Consolo, PhD — San Raffaele Scientific Institute
• Study coordinator: Filippo Consolo, PhD
• Email: consolo.filippo@unisr.it
• Phone: +390226436153

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.