Dynamic risk tools to prevent blood clots and bleeding in cancer patients
Official title: Multi-modal dynamic risk prediction of thrombosis and bleeding in patients with cancer
Funded at Baylor College of Medicine · NIH-11402709 · Data updated 2026-11-12
A new AI-based approach will predict who among people with cancer starting treatment is at higher risk for blood clots or dangerous bleeding, helping doctors tailor preventive care.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Baylor College of Medicine NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project start | August 22, 2025 |
| Project end | May 31, 2030 |
| Funding year | 2026 |
| Award (this year) | $677,991 |
| NIH project number | 5R01HL180402-02 |
| Project ID | NIH-11402709 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults with cancer who are starting systemic anticancer therapy and are at varying risks for thrombosis and bleeding.
✕Less likely to help
Patients with very low risk of clots or very high risk of bleeding may not benefit from adjusted anticoagulation strategies.
What this research studies
This project uses advanced language-model techniques and data from three US health systems to predict thrombotic and bleeding events in about 330,000 cancer patients. It will read clinical notes and other data to create a dynamic risk score that updates as patients begin or change cancer therapy. The goal is to guide personalized decisions about preventive anticoagulant therapy to reduce harm from clots while avoiding excessive bleeding. The work includes careful consideration of fairness across age, sex, race, ethnicity, and cancer type, with external validation across diverse populations.
Why it matters
Potential benefit: If successful, patients could receive more precise protection against clots with fewer bleeding complications.
How similar studies have gone: Previous studies show promise for AI-driven risk prediction, but external validation in diverse cancer populations is still needed.
Where this research is happening
-
Baylor College of Medicine
Houston, United States Active
Researchers
- Principal investigator: Li, Ang — Baylor College of Medicine
- Study coordinator: Li, Ang
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.