Clinical trial Recruiting at 1 site Interventional Ages 55 and up

Assessing cognitive decline using a new screening tool

Official title: Validation and Clinical Usability of a New Screening Tool: MASCoD - Multidimensional Assessment of Subjective Cognitive Decline

Run by Istituti Clinici Scientifici Maugeri SpA · NCT05815329 · Data updated 2026-11-12

This study is testing a new tool to see if it can help people who notice their thinking skills declining, without any other brain problems, and whether cognitive training can help them improve.

Quick facts

Study typeInterventional
Ages55 Years and up
SexAll
Enrollment100 (estimated)
SponsorIstituti Clinici Scientifici Maugeri SpA
Academic / other
Locations1 site (Montescano, Pavia)
StatusRecruiting
StartedAugust 2, 2022
Main results expectedDecember 31, 2026
Study endsDecember 31, 2026
Registry record updatedMay 8, 2025
Trial IDNCT05815329 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates for this study are adults over 55 years old who report subjective cognitive decline without any other cognitive or neurological issues.

Probably not a fit

Patients with serious clinical conditions, prior psychiatric disorders, or established cognitive decline may not benefit from this study.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study aims to evaluate the effectiveness of a new screening tool called MASCoD (Multidimensional Assessment of Subjective Cognitive Decline) in detecting and monitoring subjective cognitive decline (SCD). The study will analyze the correlation between MASCoD scores and neuropsychological evaluations, as well as brain imaging using 18F-FDG-PET to predict the risk of developing severe cognitive decline. Participants will undergo cognitive training interventions to assess the potential benefits of rehabilitation in managing SCD. The study focuses on individuals who report cognitive decline without any other neurological issues.

Why it matters

Potential benefit: If successful, this study could provide a reliable method for early detection of cognitive decline, potentially improving patient outcomes through timely interventions.

How similar studies have gone: While there are limited studies focusing on subjective cognitive decline, the approach of using a multidimensional screening tool is relatively novel and has not been extensively tested.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* reported subjective cognitive decline without any other cognitive or neurological issue,
* Italian education,
* adult (\> 55 years old),
* understanding of research aims,
* signed informed consent,
* participation on a voluntary and non-payied bases.

Exclusion Criteria:

* serious clinical conditions (e.g. severe cardiac and respiratory problems, neoplasia)
* prior diagnosis of psychiatric disorders according to DSM-5,
* prior diagnosis of cognitive decline,
* relevant visuo-perceptive or hearing deficits,
* illiteracy or relapse in illiteracy,
* refusal to partake in the research.

Where it's running

  • ICS Maugeri Montescano Institute
    Montescano, Pavia, Italy
    Recruiting

Study contacts

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.