Identifying biomarkers for cognitive impairment after stroke using fNIRS
Identifying Biomarkers Related to Post-stroke Cognitive Impairment: A fNIRS Study
This study is trying to find brain signals that can help us understand cognitive problems after a stroke by comparing stroke patients with healthy people while they do thinking tasks.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 60 (estimated) |
| Ages | 18 Years to 80 Years |
| Sex | All |
| Sponsor | First Affiliated Hospital of Chongqing Medical University Academic / other |
| Locations | 1 site (Chongqing, Chongqing Municipality) |
| Trial ID | NCT06703307 on ClinicalTrials.gov |
What this trial studies
This observational study aims to identify biomarkers associated with post-stroke cognitive impairment by utilizing functional near-infrared spectroscopy (fNIRS). It includes both healthy subjects and stroke patients, who will undergo cognitive tasks such as the Stroop task and verbal fluency tests while their brain activation is monitored. Various cognitive function assessments will be conducted to evaluate the participants' cognitive abilities and compare the results between the two groups. The goal is to uncover differences in brain activation and connectivity that may relate to cognitive decline following a stroke.
Who should consider this trial
Good fit: Ideal candidates include stroke patients aged 18-80 with a confirmed diagnosis and healthy individuals within the same age range who can complete cognitive tasks.
Not a fit: Patients with serious mental illnesses, significant organic diseases, or those unable to tolerate the tests may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved understanding and potential interventions for cognitive impairment in stroke patients.
How similar studies have performed: While this approach is innovative, similar studies using fNIRS for cognitive assessment in stroke patients have shown promise in identifying brain function changes.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: Stroke patients: 1. Diagnosis of stroke confirmed by neuroimaging (CT or MRI) 2. 18-80 years old 3. Able to complete the cognitive task 4. Able to follow instructions to complete the trial 5. Patients who signed an informed consent form. Healthy Subjects: 1. No abnormalities on cranial 2. 18-80 years old 3. Able to complete cognitive task 4. Able to follow instructions to complete the trial 5. not taking medications. 6. Subjects who signed an informed consent form. Exclusion Criteria: Stroke patients: 1. Inability to tolerate the test due to organic diseases 2. Serious mental illness that prevents them from cooperating with or tolerating the trial 3. Pregnant or lactating women 4. Had metal implants, a history of other neurological disorders, acute cardiopulmonary dysfunction. Healthy Subjects: 1. Inability to tolerate the test due to organic diseases 2. Serious mental illness that prevents them from cooperating with or tolerating the trial. 3. Pregnant or lactating women 4. Had metal implants, a history of other neurological disorders, acute cardiopulmonary dysfunction
Where this trial is running
Chongqing, Chongqing Municipality
- Department of Rehabilitation Medicine, the First Affiliated Hospital of Chongqing Medical University, Chongqing, — Chongqing, Chongqing Municipality, China (Recruiting)
Study contacts
- Study coordinator: Dingqun Bai
- Email: baidingqun@hospital.cqmu.edu.cn
- Phone: 023-89011334
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.