Longitudinal multi-omics map of cognitive decline and dementia
Official title: Longitudinal Analysis, Multi-Omics Biomarkers, and New Insights into Cognitive Decline and Dementia
Funded at University of Washington · NIH-11447242 · Data updated 2026-11-12
A long-term study at University of Washington uses blood and brain data over many years to identify biological markers linked to cognitive decline and Alzheimer’s dementia, with the goal of finding new treatment targets.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Washington NIH-funded |
| Lab location | 1 site (Seattle, United States) |
| Project start | September 1, 2026 |
| Project end | May 31, 2031 |
| Funding year | 2026 |
| Award (this year) | $658,938 |
| NIH project number | 1R01AG097473-01A1 |
| Project ID | NIH-11447242 on NIH RePORTER |
Who could benefit from this research
✓Could help
Individuals with or at risk for Alzheimer’s disease or related dementias who are already part of or eligible for long-term cohort studies may contribute through data and sample comparisons.
✕Less likely to help
People without access to the cohorts or without relevant biomarker data may see limited direct benefit.
What this research studies
This project follows thousands of older adults over years to collect blood-based omics data, brain MRIs, and detailed cognitive assessments. By combining multiple layers of biological information with long-term cognitive outcomes, researchers aim to reveal mechanisms behind dementia and prioritize druggable targets. The study uses two large cohorts, CHS and FHS, with extensive follow-up, imaging, and biomarker data to map how biology changes relate to memory and thinking abilities over time. Participants would benefit from advances in understanding and potentially earlier intervention if successful.
Why it matters
Potential benefit: If successful, the work could lead to new targets for therapies that slow or prevent cognitive decline.
How similar studies have gone: Previous multi-omics and longitudinal studies have identified promising biomarkers, but this project aims to validate and prioritize targets across diverse populations.
Where this research is happening
-
University of Washington
Seattle, United States Active
Researchers
- Principal investigator: Fohner, Alison Elizabeth — University of Washington
- Study coordinator: Fohner, Alison Elizabeth
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.