Short mild low-oxygen sessions to support brain blood-vessel health in older adults

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

The trial will enroll physically inactive adults aged 60–80 and deliver controlled intermittent hypoxic conditioning sessions, either by themselves or alongside rehabilitative exercise training, to compare effects on cerebrovascular and systemic vascular function. Researchers will measure changes in cerebrovascular health and physical capacity using established physiological tests before and after the intervention. The protocol is designed to offer hypoxic conditioning as an alternative or complement to conventional exercise for people who cannot or will not engage in standard activity programs. Safety screening will exclude participants with medical conditions that contraindicate exercise or hypoxic exposure, and the intervention will be delivered at a single clinical center with ongoing monitoring.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* 60 to 80 years of age;
* Being physically inactive (less than 150 min/week of moderate to intense physical activity);
* No chronic cardiovascular, respiratory, metabolic or neuromuscular disease counterindicating an exercise training or hypoxic conditioning program;
* Health coverage;
* Being able to provide written fully informed consent.

Exclusion Criteria:

* Body-mass index \>30 kg/m2;
* Smoking (\> cigarettes/day);
* Alcohol use (\> 10g/day);
* Mental disorder or history of mental disorder;
* Beta-blockade treatment;
* Inability or refusal to provide informed consent;
* No health coverage
* People exceeding the annual ceiling of allowances received as a result of their participation in other clinical trials;
* People deprived of freedom by judicial or administrative decision;
* People subject to legal protection, who cannot be included in clinical trials.

Where it's running

• CHU Grenoble Alpes
  La Tronche, Auvergne-Rhône-Alpes, France Recruiting

Study contacts

• Principal investigator: Stéphane Doutreleau, MD, PhD — CHU Grenoble Alpes, Grenoble Alpes University
• Study coordinator: Stéphane Doutreleau, MD, PhD
• Email: sdoutreleau@chu-grenoble.fr
• Phone: +33476767773

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.