Impact of cancer treatments on speech perception and quality of life

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to evaluate how different cancer treatments affect speech perception in noisy environments, cognitive function, and overall hearing-related quality of life in 200 cancer patients undergoing standard care. Participants will be monitored over a three-year period, with assessments including various audiometric tests and cognitive evaluations. The study will utilize questionnaires to gauge hearing-related quality of life and cognitive performance at multiple time points throughout the treatment process.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* written informed consent
* native Finnish speaker
* age-normative hearing
* for participants in the treatment arms: diagnosis of a malignancy that will be treated with curative intent with any of the following: 1) Cisplatin as the main chemotherapeutic agent, 2) oxaliplatin as the main chemotherapeutic agent, 3) cisplatin-based chemoradiation therapy in the head and neck region, 4) radiation therapy in the head and neck region

Exclusion Criteria:

* inability to provide written informed consent
* Current or prior major otological condition that has affected or has had the potential to affect hearing
* Conductive or asymmetric sensorineural HL of any severity
* Severe sensorineural HL
* Prior malignancy treated with chemotherapeutics or radiation therapy
* Prior use of ototoxic medications
* Any significant disease or disorder which, in the opinion of the investigator, may either put the subject at risk by participation in the trial, or may influence the result of the trial.
* Any condition that, in the opinion of the investigator, would interfere with adherence to the trial requirements.

For participants in the treatment arms:

* Allergy or hypersensitivity to trial medications or their ingredients
* Pregnancy or breast-feeding, aim of becoming pregnant during the trial.

Where it's running

• Turku University Hospital
  Turku, Southwest Finland, Finland Recruiting

Study contacts

• Principal investigator: Tytti Willberg, PhD — Turku University Hospital
• Study coordinator: Tytti Willberg, PhD
• Email: tytti.willberg@varha.fi
• Phone: +358 2 313 5979

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.