Reducing blood pressure to prevent cognitive decline in older adults
Preventing Cognitive Decline by Reducing BP Target Trial
This study is testing if better blood pressure management can help older adults with high blood pressure avoid memory problems and dementia.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 4000 (estimated) |
| Ages | 70 Years and up |
| Sex | All |
| Sponsor | University of Texas Southwestern Medical Center Academic / other |
| Drugs / interventions | Chemotherapy |
| Locations | 1 site (Dallas, Texas) |
| Trial ID | NCT05106036 on ClinicalTrials.gov |
What this trial studies
The PCOT trial is a multi-site randomized trial aimed at patients aged 70 and older with high blood pressure. It investigates whether a combination of clinical decision support and team-based care can improve blood pressure control and reduce the incidence of mild cognitive impairment and dementia compared to usual medical care. The study will recruit 4,000 participants from diverse health systems and assess changes in cognitive function and potential harms associated with intensive blood pressure lowering. The primary outcome will be the rate of cognitive decline measured by TICS-m scores.
Who should consider this trial
Good fit: Ideal candidates are individuals aged 70 and older with high blood pressure readings of at least 130/80 mmHg.
Not a fit: Patients with consistently low blood pressure, significant neurological diseases, or those under 70 years of age may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved cognitive health and quality of life for older adults by effectively managing blood pressure.
How similar studies have performed: Other studies have shown promising results in managing blood pressure to improve cognitive outcomes, suggesting this approach may be effective.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * High BP defined as at least 1 BP readings of SBP \>= 130 or DBP \>=80 during the 24 months prior to enrollment * Clinic visit with primary care provider within the last 24 months * Ability to write and speak English or Spanish * 70 years of age or older * Ability to understand and willingness to provide informed consent * Owns a smartphone Exclusion Criteria: * Blood pressure consistently \<130/80 mmHg * Presence of dementia, Alzheimer's disease, or significant neurological disease * Major and unstable heart disease (e.g., acute heart failure (systolic or diastolic), acute on chronic heart failure (systolic or diastolic), acute coronary syndrome or cardiac arrest, liver or renal transplantation * Under 70 years of age * Inability to write or speak English or Spanish * Chronic kidney disease stage 5 or ESKD * Chemotherapy * Any conditions judged by the medical providers to contraindicate participation due to risk to patient safety or lack of adherence * Expected life expectancy under a year
Where this trial is running
Dallas, Texas
- UT Southwestern Medical Center — Dallas, Texas, United States (Recruiting)
Study contacts
- Study coordinator: Venkatraghavan Sundaram, Ph.D.
- Email: venkatraghavan.sundaram@phhs.org
- Phone: 214-590-3848
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.