Investigating the causes and progression of neurocognitive disorders in Thailand

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to predict the progression of neurocognitive disorders, including dementia and Alzheimer's disease, in the Thai population. It will evaluate plasma phosphorylated tau levels and cognitive test scores to develop a predictive model for cognitive decline. Participants, including healthy individuals and those with mild cognitive impairment or late-onset dementia, will undergo biospecimen collection, structured interviews, and cognitive examinations, with follow-up visits scheduled annually or biennially. The study also seeks to understand the socioeconomic impact of these disorders and establish a biorepository for future research.

Why it matters

Who can join: the full rules

1. Cognitively Healthy Individuals

   INCLUSION CRITERIA
   * Demonstrate normal cognitive function within the expected range on objective cognitive tests.
   * Proficient in speaking and understanding Thai without the need for a translator to participate.

   EXCLUSION CRITERIA
   * Significant neurological or uncontrolled psychiatric illness.
   * Significant unstable systemic condition or end-stage organ failure that affects study participation.
2. Mild Cognitive Impairment

   INCLUSION CRITERIA
   * Display impaired/abnormal performance on objective cognitive tests.
   * Does not meet criteria for dementia per NIA-AA (or major neurocognitive disorder per DSM-5).
   * Proficient in speaking and understanding Thai without the need for a translator to participate.

   EXCLUSION CRITERIA
   * Significant neurological or uncontrolled psychiatric illness.
   * Significant unstable systemic condition or end-stage organ failure that affects study participation.
3. Late Onset Dementia

   INCLUSION CRITERIA
   * Display impaired/abnormal performance on objective cognitive tests.
   * Meets criteria for dementia per NIA-AA (or major neurocognitive disorder per DSM-5), including dementia due to Alzheimer's disease or other causes.
   * Begins to experience symptoms, identified by the physician as a part of dementia continuum, occurring after the age of 65.
   * Proficient in speaking and understanding Thai without the need for a translator to participate.

   EXCLUSION CRITERIA
   * Significant neurological or uncontrolled psychiatric illness.
   * Significant unstable systemic condition or end-stage organ failure that affects study participation.
4. Early Onset Dementia

INCLUSION CRITERIA

* Display impaired/abnormal performance on objective cognitive tests.
* Meets criteria for dementia per NIA-AA (or major neurocognitive disorder per DSM-5), including dementia due to Alzheimer's disease or other causes.
* Begins to experience symptoms, identified by the physician as a part of dementia continuum, occurring before the age of 65.
* Proficient in speaking and understanding Thai without the need for a translator to participate.

EXCLUSION CRITERIA

* Significant neurological or uncontrolled psychiatric illness.
* Significant unstable systemic condition or end-stage organ failure that affects study participation.

Where it's running

• King Chulalongkorn Memorial Hospital
  Pathum Wan, Bangkok, Thailand Recruiting

Study contacts

• Principal investigator: Thiravat Hemachudha, M.D. — Chulalongkorn University
• Study coordinator: Poosanu Thanapornsangsuth, M.D.
• Email: poosanu.t@chula.ac.th
• Phone: +66 (0)2 2564000

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.