Exploring the effects of sleep loss on aging and cognitive decline

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study investigates the impact of sleep deprivation on cognitive function and aging by analyzing blood samples from participants of varying ages and cognitive levels. It includes healthy individuals, those with mild cognitive impairment (MCI), and Alzheimer's disease (AD) patients. Participants will undergo cognitive assessments and sleep screenings, with blood samples collected before and after sleep deprivation for multi-omics analysis. The goal is to identify molecular biomarkers that link sleep loss with aging and neurodegenerative diseases.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Signed informed consent form；
2. Meet the inclusion criteria for each arms.

Exclusion Criteria:

1. Failure to provide informed consent;
2. Inability to follow study procedures due to issues such as language barriers or cognitive impairment;
3. Regular use of medications that may alter the relationship between sleep and outcome variables (e.g., opioid medications, benzodiazepines, and Z drugs \[non-benzodiazepine hypnotics\]);
4. History of alcohol abuse, substance abuse, consciousness disorders, cerebrovascular disease, head injury, epilepsy, encephalitis, or other neurological disorders;
5. Diagnosis of schizophrenia, severe depression, anxiety disorders, or other severe psychiatric conditions;
6. Presence of severe arrhythmias, myocardial infarction within the last 6 months, severe pulmonary dysfunction, renal or hepatic insufficiency, severe anemia, severe gastrointestinal diseases, tumors, or other severe medical conditions.

Where it's running

• The First Affiliated Hospital of Zhejiang University
  Hangzhou, Zhejiang, China Recruiting

Study contacts

• Principal investigator: Benyan Luo — Zhejiang University
• Study coordinator: Benyan Luo, Prof
• Email: luobenyan@zju.edu.cn
• Phone: 0571-87236537

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.