Aerobic exercise program for older adults with mild cognitive impairment

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This clinical trial aims to evaluate the effects of a 6-month aerobic exercise program on older adults aged 65 and above who have mild cognitive impairment or early Alzheimer's disease. Participants will engage in various exercise interventions, including moderate intensity continuous training and high-intensity interval training, while undergoing cognitive assessments and MRI scans to monitor changes in brain health and fitness levels. The study seeks to identify the most effective exercise regimen for improving aerobic fitness and cognitive outcomes, as well as to explore the underlying mechanisms of exercise on memory function. Monthly follow-ups will provide additional support and health discussions for participants throughout the trial.

Why it matters

Who can join: the full rules

Inclusion Criteria:

Participants:

* Clinical diagnosis of MCI or probable and possible mild AD dementia according to 2011 Alzheimer's association-NIA criteria.
* Community-dwelling, e.g., homes and assisted living
* Age 65 years and older
* Medical clearance from PCP or cardiovascular provider
* Have a qualified study partner
* Agree to the blood draws
* Verified MRI safety

Study Partner:

* Age 18 or older
* Contact with participant ≥ 2 times per week for ≥ 6 months
* Know the participant's memory status and ability to perform activities of daily living
* Consent to participant

Exclusion Criteria:

Participants

* Resting HR ≤ 50 or ≥ 100 beats/min after 5-minutes of quiet resting
* American College of Sports Medicine contraindications to exercise
* New, unevaluated symptoms or diseases a healthcare provider has not evaluated
* Abnormal cardiac condition uncovered during VO2peak testing
* Enrollment in another intervention that aims at improving cognition
* Moderate to strenuous exercise ≥150 minutes a week in the previous 6 months
* ≥ 2 anti-depression medications, or poorly managed or unstable depression
* Poorly managed or unstable anxiety

Study partners:

* none

Where it's running

• Arizona State University
  Phoenix, Arizona, United States Recruiting

Study contacts

• Principal investigator: Fang Yu, PhD — Arizona State University
• Study coordinator: Kristi Spieleder, MS
• Email: kspieled@asu.edu
• Phone: 480-884-2765

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.