Condition

Cognitive Change clinical trials and research

• 28Clinical trials
• 6NIH research projects
• 9Countries

Newest Cognitive Change clinical trials

All recruiting trials (28)

• Early Cognitive Interventions in Digital Format for Cancer Survivors: Home-Based Training for CRCI

  Two digital cognitive training programs done at home (one computerized, one virtual reality) are tested to see if they help adults with cancer-related cognitive changes more than usual care.

  Recruiting at 3 sites Biogipuzkoa Health Research Institute · Bilbao, Bizkaia and 2 other locations · NCT07729969

• Early cognitive changes after same-day hip or knee replacement

  This study tests whether older adults (65 or older, 70 per description) who have same-day discharge after hip or knee replacement show changes in cognitive test performance from before surgery to the first day after surgery.

  Recruiting Odense University Hospital · Svendborg · NCT07598552

• Integrated Data for Healthy Aging in Taiwan

  This project tests whether combining clinical data, genomics, and microbiome information can help identify early aging-related risks in adults 40 and older in Taiwan.

  Recruiting at 2 sites Chang Gung Memorial Hospital · Taipei and 1 other locations · NCT07414680

• How indoor heat affects people with schizophrenia

  This study will test whether simulated indoor overheating causes more physiological stress and worsened cognitive symptoms in people with schizophrenia compared with people without schizophrenia.

  Recruiting University of Ottawa · Ottawa, Ontario · NCT07383324

• Brain Health PRO online program to reduce dementia risk

  This online program tests whether a six‑month lifestyle education plan can help people aged 50–80 who are at risk for dementia reduce their risk factors.

  Recruiting University of British Columbia · Vancouver, British Columbia · NCT07364019

• Keeping indoor temperature at 26 °C to reduce heat strain in healthy young adults

  This will test whether keeping indoor temperatures at 26 °C protects healthy, habitually active young adults from heat strain and cognitive changes.

  Recruiting University of Ottawa · Ottawa, Ontario · NCT07267598

• How indoor overheating affects children's bodies and thinking

  This project will test whether keeping indoor air at or below 26 °C (about 45% relative humidity) reduces heat-related physical strain and short-term cognitive changes in children.

  Recruiting University of Ottawa · Ottawa, Ontario · NCT07261202

• Executive function training for 12–17-year-olds

  This project will test six different executive-function training programs to see which help 12–17-year-olds with and without ADHD improve working memory, attention, and self-control.

  Recruiting Northeastern University · Boston, Massachusetts · NCT07147894

• How chemotherapy given before surgery affects thinking and memory in ovarian cancer

  This study will test whether chemotherapy given before surgery affects thinking and memory in people with newly diagnosed advanced epithelial ovarian cancer.

  Recruiting University of Wisconsin, Madison · Madison, Wisconsin · NCT07125209

• High-definition non-invasive brain stimulation for word-finding problems after chronic traumatic brain injury

  This trial tries short sessions of non-invasive high-definition transcranial direct current stimulation (HD-tDCS) to see if they help adults with long-term traumatic brain injury who have trouble finding words and remembering things.

  Recruiting Beth Israel Deaconess Medical Center · Boston, Massachusetts · NCT06848140

• Memantine plus structured exercise to protect thinking and memory during breast cancer chemotherapy

  This will test whether memantine combined with a supervised exercise program, memantine alone, or a placebo can prevent or reduce thinking and memory problems in people receiving chemotherapy for stage I–III breast cancer.

  Recruiting Phase 2 UNC Lineberger Comprehensive Cancer Center · Chapel Hill, North Carolina · NCT06727773

• Eating trout may improve brain health in young children and families

  This study is testing if eating more trout can help improve brain health and emotional well-being in young children and their families.

  Recruiting at 2 sites University of Idaho · Moscow, Idaho and 1 other locations · NCT06721468

• Improving brain and heart health through a specific diet

  This study is testing if following the MIND diet can improve brain and heart health in middle-aged adults compared to a standard healthy diet.

  Recruiting University of Illinois at Urbana-Champaign · Urbana, Illinois · NCT06605898

• Evaluating the MIND diet for cognitive improvement in Multiple Sclerosis

  This study is testing if following the MIND diet can help people with Multiple Sclerosis improve their memory and thinking skills.

  Recruiting University of Illinois at Urbana-Champaign · Urbana, Illinois · NCT06450977

• Research on improving kindergarten yards for children's health

  This study is testing whether making kindergarten yards more natural and full of plants can improve the health and learning of children aged 1-5 by looking at things like allergies, asthma, and their overall well-being.

  Recruiting at 2 sites Natural Resources Institute Finland · Helsinki, Uusimaa and 1 other locations · NCT06390878

• Cognitive training effectiveness in different age groups

  This study is testing if cognitive training can help improve thinking skills in both younger and older adults by having them complete tasks and answer questions over several weeks.

  Recruiting at 3 sites University of Wisconsin, Madison · Riverside, California and 2 other locations · NCT06375681

• Understanding cognitive changes in children aged 7 to 10

  This study looks at how children's thinking skills change between ages 7 and 10 to see what makes them different and how these differences might affect them later in life.

  Recruiting Radboud University Medical Center · Nijmegen · NCT06330090

• Evaluating health changes in patients with Obstructive Sleep Apnea after ventilotherapy

  This study is testing how three weeks of ventilotherapy affects the health, thinking skills, and overall wellbeing of people with Obstructive Sleep Apnea.

  Recruiting Istituto Auxologico Italiano · Piancavallo, VCO · NCT06312956

• Improving sleep apnea treatment and cognitive health in Native American elders

  This study is testing a new way to help Native American elders with sleep apnea stick to their treatment and see if it also helps their thinking skills.

  Recruiting Washington State University · Eagle Butte, South Dakota · NCT06227572

• Diet intervention to improve cognitive health in patients with carotid stenosis

  This study is testing whether following a special diet for six months can help improve brain health in people aged 40 and older with narrowed arteries in the neck.

  Recruiting Second Affiliated Hospital, Zhejiang University, School of Medicine · Hangzhou, Zhejiang · NCT05922137

• Training to improve cognitive performance through perceptual learning

  This study is testing different training methods to see if they can help improve thinking skills in younger and older adults with normal or corrected vision.

  Recruiting at 2 sites University of Wisconsin, Madison · Riverside, California and 2 other locations · NCT05894967

• Personalized ECT for better depression treatment outcomes

  This study is testing if adjusting the strength of ECT treatment for depression can help older adults feel better and think more clearly compared to using a standard strength.

  Recruiting University of New Mexico · Albuquerque, New Mexico · NCT05699226

• Exercise to enhance brain health in older African Americans

  This study is testing whether two types of exercise, Cardio-Dance Fitness and Strength, Flexibility, and Balance, can help improve brain health and lower Alzheimer's risk in older African Americans.

  Recruiting Phase 2 Rutgers, The State University of New Jersey · Newark, New Jersey · NCT05597124

• Training older adults to improve trust-related decision making

  This study is testing whether training older adults with neurofeedback can help them make better trust-related decisions, especially those dealing with neurodegenerative diseases like Alzheimer's.

  Recruiting University of Florida · Gainesville, Florida · NCT05457725

• Improving math skills in children with learning disabilities

  This study tests a new way to help children with learning disabilities improve their math skills by using different methods to see what works best for them.

  Recruiting Stanford University · Palo Alto, California · NCT05201534

• Examining brain changes in colorectal cancer patients undergoing chemotherapy

  This study is trying to see how chemotherapy affects thinking and memory in people with colorectal cancer.

  Recruiting Parkview Health · Fort Wayne, Indiana · NCT05014399

• Effects of exercise timing on memory in young adults

  This study tests how exercising at different times of the day affects memory in healthy young adults aged 18-25.

  Recruiting University of North Carolina, Greensboro · Greensboro, North Carolina · NCT04861818

• Group rehabilitation for patients with chronic fatigue syndrome

  This study is testing a group therapy program to see if it can help people with chronic fatigue syndrome feel better and manage their illness more effectively.

  Recruiting Joint Authority for Päijät-Häme Social and Health Care · Lahti · NCT04151693

NIH-funded research (6)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Tailoring blood pressure to protect brain blood flow during and after heart surgery

  Aims to see if monitoring each person's brain blood-flow limits and personalizing blood-pressure targets during and after heart surgery reduces delirium and longer-term memory and thinking problems.

  NIH research Stanford University · Stanford, United States · NIH-11310140

• Genes linked to early thinking and memory decline before dementia

  Researchers are looking at people's genes to find changes tied to earlier declines in memory and thinking before Alzheimer's develops.

  NIH research University of Texas at Austin · Austin, United States · NIH-11128831

• Using sensors in cars to detect cognitive changes in older drivers

  This study is looking at how special sensors in cars can help keep an eye on how older drivers are doing behind the wheel, to spot early signs of memory problems like Alzheimer's, and it’s for older adults who want to stay safe and independent while driving.

  NIH research Florida Atlantic University · Boca Raton, United States · NIH-11081181

• Understanding genetic factors in cognitive decline before dementia starts

  This study is looking at how our genes might affect memory and thinking problems as we get older, especially for people at risk of Alzheimer's and similar conditions, to help find ways to spot these issues earlier and improve care.

  NIH research University of Texas at Austin · Austin, United States · NIH-10891784

• Understanding brain blood flow and its effects on recovery after heart surgery

  This study is looking at how blood flow to the brain after heart surgery can affect your thinking and memory, and it aims to find the best ways to manage your blood pressure during recovery to help prevent problems like confusion and memory loss.

  NIH research Stanford University · Stanford, United States · NIH-10883892

• Using vehicle sensors to monitor cognitive changes in older drivers

  This study is looking at how special sensors in cars can help spot early signs of memory changes in older adults who might be at risk for Alzheimer's and similar conditions, by keeping track of their driving habits and daily activities over three years.

  NIH research Florida Atlantic University · Boca Raton, United States · NIH-10836454

Related topics

Quick answers

How many Cognitive Change clinical trials are recruiting right now?

28, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 9 countries. The most sites are in United States (16 trials), Canada (4 trials), Finland (2 trials), Spain (1 trial), Netherlands (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2: 2. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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