NIH-funded research R01 grant

Exercise and brain health in older adults with kidney disease

Official title: Accelerated Age-related Cognitive Decline: Impact of Exercise on Executive Function and Neuroplasticity (EXEC- study)

Funded at Georgetown University · NIH-11530743 · Data updated 2026-11-12

A study to see if a structured exercise program can slow cognitive decline in older adults with chronic kidney disease who are at risk for dementia.

Quick facts

Grant typeR01 grant
Study typeNIH-funded research
Funding institutionGeorgetown University
NIH-funded
Lab location1 site (Washington, United States)
Project startMay 1, 2022
Project endApril 30, 2028
Funding year2026
Award (this year)$486,896
NIH project number7R01AG076456-04
Project IDNIH-11530743 on NIH RePORTER

Who could benefit from this research

Could help

Older adults with chronic kidney disease who are at risk for accelerated cognitive decline or ADRD.

Less likely to help

Individuals without CKD or those with advanced dementia may not experience benefit from this exercise-focused approach.

What this research studies

This project focuses on older adults with chronic kidney disease who are at increased risk for accelerated cognitive aging and Alzheimer’s-related dementia. Participants will engage in a non-drug, exercise-based program designed to target brain health and cognitive function, with measurements of brain structure and blood flow. The study aims to identify whether physical activity can preserve memory and executive function by improving white matter integrity and brain perfusion. Results could inform practical, non-pharmacologic ways to protect cognition in CKD patients as they age.

Why it matters

Potential benefit: If successful, the program could help CKD patients maintain independence and adherence to medications by slowing cognitive decline.

How similar studies have gone: Previous research suggests exercise can benefit brain health in aging, but this specific CKD-focused approach is novel and exploratory.

Where this research is happening

  • Georgetown University
    Washington, United States
    Active

Researchers

  • Principal investigator: Bronas, Ulf G — Georgetown University
  • Study coordinator: Bronas, Ulf G

Related research

Other NIH-funded projects on the same topics.

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.