Exercise and brain health in older adults with kidney disease
Official title: Accelerated Age-related Cognitive Decline: Impact of Exercise on Executive Function and Neuroplasticity (EXEC- study)
Funded at Georgetown University · NIH-11530743 · Data updated 2026-11-12
A study to see if a structured exercise program can slow cognitive decline in older adults with chronic kidney disease who are at risk for dementia.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Georgetown University NIH-funded |
| Lab location | 1 site (Washington, United States) |
| Project start | May 1, 2022 |
| Project end | April 30, 2028 |
| Funding year | 2026 |
| Award (this year) | $486,896 |
| NIH project number | 7R01AG076456-04 |
| Project ID | NIH-11530743 on NIH RePORTER |
Who could benefit from this research
✓Could help
Older adults with chronic kidney disease who are at risk for accelerated cognitive decline or ADRD.
✕Less likely to help
Individuals without CKD or those with advanced dementia may not experience benefit from this exercise-focused approach.
What this research studies
This project focuses on older adults with chronic kidney disease who are at increased risk for accelerated cognitive aging and Alzheimer’s-related dementia. Participants will engage in a non-drug, exercise-based program designed to target brain health and cognitive function, with measurements of brain structure and blood flow. The study aims to identify whether physical activity can preserve memory and executive function by improving white matter integrity and brain perfusion. Results could inform practical, non-pharmacologic ways to protect cognition in CKD patients as they age.
Why it matters
Potential benefit: If successful, the program could help CKD patients maintain independence and adherence to medications by slowing cognitive decline.
How similar studies have gone: Previous research suggests exercise can benefit brain health in aging, but this specific CKD-focused approach is novel and exploratory.
Where this research is happening
-
Georgetown University
Washington, United States Active
Researchers
- Principal investigator: Bronas, Ulf G — Georgetown University
- Study coordinator: Bronas, Ulf G
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.