Lifestyle intervention for older adults at risk of dementia

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This trial evaluates a tailored lifestyle intervention aimed at reducing dementia risk among older adults with subjective cognitive decline (SCD) and mild cognitive impairment (MCI). It involves a randomized controlled design with 300 participants, who are assigned to either a personalized lifestyle intervention group or a general health advice group for 12 months. The intervention includes lifestyle coaching, a voucher program, and online self-management tools. The study aims to assess the effectiveness of the intervention in improving participants' dementia risk profiles and to explore the feasibility of implementing such interventions in routine care.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* ≥50 years of age at pre-screening;
* Having a diagnosis of SCD or MCI;
* Presence of ≥ 2 modifiable risk factors for dementia.

Exclusion Criteria:

* Having a diagnosis of dementia;
* Insufficient understanding of the Dutch language;
* Conditions affecting safe and continuous engagement in the intervention (e.g. under treatment for current malignant diseases, major psychiatric disorders (e.g. major depression, psychosis, bipolar disorder), other conditions preventing co-operation as judged by the local study nurse or consulted physician at the local study site;
* Participation in any other research intervention trial at time of pre-screening and throughout the study period.

Where it's running

• Maastricht University
  Maastricht, Netherlands Recruiting
• Alzheimer Center Amsterdam
  Amsterdam, Netherlands Completed

Study contacts

• Principal investigator: Sebastian Köhler, Professor — Maastricht University
• Study coordinator: Niels Janssen, PhD
• Email: n.janssen@maastrichtuniversity.nl
• Phone: +316 14348188

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.