Condition

Mild Cognitive Impairment (MCI) clinical trials and research

• 79Clinical trials
• 6NIH research projects
• 4New in 30 days
• 26Countries

Newest Mild Cognitive Impairment (MCI) clinical trials

All recruiting trials (79)

• Rural Veterans and Care Partners Walking Program

  A virtual walking program is tested to see if it can help Veterans with mild cognitive impairment and their care partners in rural areas walk more each day.

  Recruiting Creighton University · Omaha, Nebraska · NCT07914218

• China HEAD: a large community study on healthy aging and dementia

  This study tests whether collecting health, imaging, and biospecimen data from adults in China can help predict who will develop Alzheimer’s disease and related dementias.

  Recruiting at 30 sites Fudan University · Beijing and 29 other locations · NCT07912710

• Aging Brain Health Initiative in Fujian

  This observational study will follow about 3,000 older adults in Fujian to see how Alzheimer's-related changes develop and to test new digital tests, biomarkers, and imaging tools for early diagnosis.

  Recruiting at 4 sites Fujian Medical University Union Hospital · Fushun, Fujian and 3 other locations · NCT07891429

• See if multimodal biomarkers can map changes from mild cognitive impairment to dementia

  This observational study tests whether clinical, blood, and brain-imaging markers can tell apart stages of cognitive decline and predict progression from mild cognitive impairment to dementia in about 600 people.

  Recruiting Xuanwu Hospital, Beijing · Beijing, Beijing Municipality · NCT07876570

• LIFU to Help Sleep and Amyloid Reduction in Older Adults with Cognitive Impairment

  A wearable ultrasound device (ATTN201) is being tested to see if it’s safe and easy to use for people 65 and older with mild cognitive impairment and amyloid buildup.

  Recruiting University of California, San Francisco · San Francisco, California · NCT07866768

• Digital STEADI: A home-based digital fall prevention program for older adults

  A home-based digital program using AI-driven conversational agents tests if a guided fall-prevention exercise plan can reduce fall risk for older adults with mild cognitive impairment living independently.

  Recruiting Phase 1/2 Friendi.fi Corporation · Atlanta, Georgia · NCT07852650

• Photobiomodulation therapy for mild cognitive impairment and mild Alzheimer's disease

  This trial tests whether daily transcranial near-infrared light therapy, versus a sham device, can improve cognitive function in adults with mild cognitive impairment or mild Alzheimer's disease.

  Recruiting Beijing Tiantan Hospital · Beijing · NCT07835399

• Temporal Interference Stimulation With Tai Chi for Mild Cognitive Impairment

  Researchers are testing whether a personalized brain stimulation technique together with Tai Chi can improve thinking skills and multitasking in people with mild cognitive impairment.

  Recruiting Shanghai University of Sport · Shanghai, Shanghai Municipality · NCT07799584

• LpD3.5 Intervention for Gut Health and Cognition in Older Adults with MCI

  In older adults with mild cognitive impairment, this study tests whether daily LpD3.5 capsules can improve gut health and potentially cognition compared with placebo.

  Recruiting Early Phase 1 University of South Florida · Tampa, Florida · NCT07794956

• Gut methane and Parkinson's: measuring if a probiotic helps people with Parkinson's, REM sleep behavior disorder, or cognitive concerns

  This study tests whether a probiotic containing Limosilactobacillus reuteri can help people with Parkinson's disease, those at high risk for PD, and related cognitive issues by potentially improving gut methane levels and overall symptoms.

  Recruiting University of Cambridge · Cambridge, CB2 · NCT07786116

• Integrated vs. Sequential Dual-Task Training for older adults with mild to moderate cognitive impairment

  This study tests whether combining cognitive and physical tasks at the same time is more helpful than doing them separately for people over 55 with mild to moderate cognitive impairment.

  Recruiting Shifa Tameer-e-Millat University · Islamabad, Islamabad · NCT07775079

• Hippocampal Temporal Interference Stimulation for Memory and Posture in Older Adults with Mild Cognitive Impairment

  Researchers test whether a single session of 40 Hz hippocampal temporal interference stimulation can improve memory and dual-task balance in older adults with mild cognitive impairment, compared to sham stimulation.

  Recruiting Shanghai University of Sport · Shanghai, Shanghai Municipality · NCT07771036

• Brain PET imaging with [18F]Fluorbetazine to see amyloid plaques in people with normal thinking, MCI, or Alzheimer’s

  This study tests a PET scan using [18F]Fluorbetazine to see if it can reliably detect amyloid plaques in the brain across people with normal cognition, MCI, or Alzheimer's disease.

  Recruiting Phase 3 HTA Co., Ltd. · Beijing, Beijing Municipality · NCT07764679

• Safe hydrogen inhalation in people with mild cognitive impairment

  This study tests whether inhaling hydrogen gas for one hour daily is safe and possible to help cognition in people with mild cognitive impairment.

  Recruiting Phase 2 University of Ostrava · Ostrava, Moravian-Silesian Region · NCT07757542

• Oral Motor and Cognitive Dual-Task Training for Oral Frailty and Cognitive Impairment

  This program tests if combining oral-motor exercises with simple thinking tasks can improve mouth function and thinking skills in adults with oral frailty and mild-to-moderate cognitive impairment.

  Recruiting The Hong Kong Polytechnic University · Kowloon, Hong Kong and 1 other locations · NCT07733726

• See if cognitive impairment is common in older adults admitted for non-neurological rehab

  This study tests how often cognitive impairment appears in patients aged 45 and older who are in non-neurological rehab units after hospitalization.

  Recruiting at 3 sites Fondazione Don Carlo Gnocchi ETS · Florence, FI and 2 other locations · NCT07731334

• Digital tools to predict Alzheimer's biology from risk factors

  This study tests a digital, AI-based tool that analyzes modifiable and non-modifiable risk factors to see if it can predict biological changes linked to Alzheimer's disease in adults with MCI or SCD.

  Recruiting at 2 sites IRCCS Centro San Giovanni di Dio Fatebenefratelli · Brescia, BS and 1 other locations · NCT07731191

• Hydroxytyrosol-rich olive polyphenol with the Mediterranean diet for cognitive health in adults with mild cognitive impairment

  This study tests whether adding a hydroxytyrosol-rich olive polyphenol supplement to a Mediterranean diet can help preserve thinking skills in adults aged 50–85 with mild cognitive impairment.

  Recruiting Panhellenic Federation of Alzheimer's Disease and Related Disorders · Thessaloniki, Central Macedonia · NCT07672938

• Rhythmic Auditory Stimulation to Improve Gait and Brain Function in Alzheimer's Disease

  A rhythm-based metronome approach is being tested to see if it helps people with Alzheimer's disease and mild cognitive impairment walk more smoothly and think more clearly.

  Recruiting Boston University Charles River Campus · Boston, Massachusetts · NCT07659964

• rTMS with aerobic exercise for older adults with mild cognitive impairment and depressive symptoms

  This trial tests whether rTMS alone or rTMS plus stationary cycling can improve thinking skills and mood in older adults with MCI and depression.

  Recruiting Cheng-Hsin General Hospital · Taipei, Taipei City · NCT07652775

• Using near-infrared light to help brain blood flow and thinking in people with mild cognitive impairment

  This trial tests whether daily 20-minute transcranial photobiomodulation with near-infrared light can improve brain blood flow regulation and memory in people with mild cognitive impairment.

  Recruiting University of Oklahoma · Oklahoma City, Oklahoma · NCT07651787

• VR-based cognitive training for adults with type 2 diabetes and mild cognitive impairment

  A 40-person randomized study in adults with type 2 diabetes and mild cognitive impairment tests whether a VR-based cognitive training program with diabetes self-management beats traditional paper-and-pencil cognitive training.

  Recruiting The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School · Nanjing, Jiangsu · NCT07650318

• Motor reserve in the early stages of dementia: a look at movement in people with MCI and healthy adults

  This study tests whether motor performance and movement patterns can reveal motor reserve in people with mild cognitive impairment and in healthy adults.

  Recruiting Istituto per la Ricerca e l'Innovazione Biomedica · Catanzaro, Catanzaro · NCT07634055

• Dementia with Lewy Bodies: Symptoms, Biomarkers and Progression

  This study tests how well clinical features, biological markers, and brain scans distinguish DLB and its early stages in patients seen at Stockholm clinics.

  Recruiting Karolinska Institutet · Stockholm · NCT07629349

• Percepta for cognitive optimization in adults with mild cognitive impairment

  A 6-month, randomized, double-blind study tests whether the Percepta supplement helps memory and thinking in adults 40–85 with mild cognitive impairment, compared with a placebo.

  Recruiting Cerebrum DAO Association · Wilmington, Delaware · NCT07612449

• CROWN-I: Learning About Molecular Differences in Alzheimer’s and MCI

  Researchers will follow adults aged 55 and up with Alzheimer's, MCI, or normal cognition to see if molecular and genetic patterns in olfactory neurons and blood can identify subtypes and predict progression.

  Recruiting Crownlands · Germantown, Maryland · NCT07611396

• Mindfulness plus dual-task training for people after stroke with mild cognitive impairment

  This study tests whether combining mindfulness with dual-task training can help improve thinking skills and physical function in people who recently had a stroke and have mild cognitive impairment.

  Recruiting Nanjing Mingzhou Rehabilitation Hospital · Nanjing · NCT07603102

• Adaptive computerized training to boost thinking in healthy seniors and those with mild cognitive impairment

  This study tests whether a computer-based training program can improve executive thinking in older adults, including those with mild cognitive impairment, and see if it also helps memory and well-being.

  Recruiting at 2 sites Universidad Antonio de Nebrija · Madrid, Madrid and 1 other locations · NCT07598409

• GGC oral supplement in people with mild cognitive impairment

  This study tests whether taking Gamma Glutamylcysteine (GGC) at different daily doses is safe and tolerable for adults with mild cognitive impairment over three months.

  Recruiting Phase 1 University of Pittsburgh · Pittsburgh, Pennsylvania · NCT07583251

• RP902 tablets for mild cognitive impairment (MCI)

  This phase 2 trial tests whether RP902 tablets can help people with MCI related to Alzheimer's disease compared with a placebo.

  Recruiting at 2 sites Phase 2 Risen (Suzhou) Pharma Tech Co., Ltd. · Beijing, Beijing Municipality and 1 other locations · NCT07579884

• Community screening with blood biomarkers for Alzheimer's in older adults

  This project will test whether two blood biomarkers (pTau217/Aβ42 ratio and GFAP) can detect Alzheimer's disease or mild cognitive impairment in community-dwelling older adults.

  Recruiting at 4 sites Shanghai Fengxian District Central Hospital · Shanghai, Shanghai Municipality and 3 other locations · NCT07570719

• Non-invasive deep brain stimulation to try to improve working memory in older adults

  This trial will test whether gentle, non-invasive electrical stimulation aimed at deep brain regions can improve working memory, attention, and everyday thinking in healthy older adults and people with mild cognitive impairment.

  Recruiting Masaryk University · Brno · NCT07560904

• Non-invasive brain stimulation plus computer-based memory training for mild cognitive impairment

  This trial will test whether a short course of non-invasive brain stimulation combined with one of two computer-based brain-training programs helps people aged 60–85 with mild cognitive impairment improve memory, thinking, mood, and daily function.

  Recruiting Medical University of South Carolina · Charleston, South Carolina · NCT07526740

• Group exercises to improve thinking and daily lifestyle for people with mild cognitive impairment

  This program tests whether a 12-week group multimodal cognitive and lifestyle exercise program can help people with mild cognitive impairment improve thinking, behavior, and everyday functioning.

  Recruiting Casa di Cura IGEA · Milan, Milano and 1 other locations · NCT07517380

• Predicting pre-dementia progression in APOE‑ε4 carriers

  This project will try a combined genetic, blood, and wearable-monitoring model to see if it can predict which cognitively normal or very mildly impaired adults aged 55+ with an APOE‑ε4 gene will develop biomarker-confirmed MCI within 24 months.

  Recruiting Prevention Research Consortium Corp. · San Diego, California · NCT07516119

• Creating a Korean cohort to track cognitive aging

  This project will use smartphone surveys, a wearable watch, and blood tests to see if daily emotional stress is linked to short- and long-term thinking problems and inflammation in adults 60 and older in Seoul.

  Recruiting Korea University · Seoul, Select One... · NCT07485387

• e-ALIGN: Using the patient portal to align medicines with what matters most

  This project will see if sending education through the patient portal plus pharmacist-led medication reviews helps people 65 and older with mild cognitive impairment or dementia and their care partners reduce risky brain-active medicines.

  Recruiting Johns Hopkins University · Baltimore, Maryland · NCT07454824

• Enhancing Attention in Older Adults Using a Brain-Computer Interface

  This study tests whether non-invasive brain stimulation plus mindfulness training can boost attention and memory markers in older adults with mild cognitive impairment.

  Recruiting at 2 sites University of Texas at Austin · Austin, Texas and 1 other locations · NCT07441122

• Ear-based vagus nerve stimulation to boost decision-making and other thinking skills in people with Parkinson's and healthy adults

  This project will try gentle electrical stimulation of the ear (taVNS) to see if it improves decision-making and other thinking skills in people with Parkinson's disease and in healthy adults.

  Recruiting University of Colorado, Denver · Aurora, Colorado · NCT07424365

• Instant-message personalized Acceptance and Commitment Therapy for neuropsychiatric symptoms in mild cognitive impairment

  This test sends personalized instant messages based on Acceptance and Commitment Therapy to see if they reduce neuropsychiatric symptoms in people aged 50 and older with mild cognitive impairment.

  Recruiting The University of Hong Kong · Hong Kong · NCT07420426

• Five-week Telehealth Cognitive Training for Mild Cognitive Impairment

  A five-week, at-home, telehealth program tests whether a shorter cognitive training works as well as the original eight-week version for people with mild cognitive impairment.

  Recruiting University of Florida · Gainesville, Florida · NCT07366346

• Primary aldosteronism and thinking/memory problems

  This study will see if people aged 40 and older with primary aldosteronism develop memory and thinking problems over 1 to 5 years and which factors influence those changes.

  Recruiting at 2 sites Xinjiang Medical University · Chengdu, Sichuan and 1 other locations · NCT07304674

• Online positive psychology program to support thinking and brain health in early memory changes

  This study will test whether an online positive psychology program can improve thinking, brain function, and wellbeing in older adults with early memory problems (Subjective Cognitive Decline or Mild Cognitive Impairment).

  Recruiting Aristotle University Of Thessaloniki · Thessaloniki · NCT07289061

• Cognitive function, daily independence, and mood in people with dementia or MCI.

  We will see how thinking abilities, independence in everyday activities, and mood change over time in people aged 50–86 with dementia or mild cognitive impairment using repeated clinic assessments.

  Recruiting IRCCS Centro Neurolesi Bonino Pulejo · Messina, ME · NCT07287410

• Personalized digital training for cognitive fitness in people with mild cognitive impairment

  This study tests whether a personalized home-based digital program (RICORDO) helps people aged 50 and older with mild cognitive impairment or subjective cognitive decline manage their health and daily life better than a paper-and-video education program.

  Recruiting at 2 sites University of Modena and Reggio Emilia · Modena, Reggio Nell'Emilia (RE) and 1 other locations · NCT07286448

• NPC-1 (parthenolide and ipriflavone) for Alzheimer's blood biomarkers

  This trial will test whether taking NPC-1 (a combination of parthenolide and ipriflavone) is safe, well tolerated, and changes blood tests linked to Alzheimer's in adults 55+ with subjective cognitive decline, mild cognitive impairment, or mild Alzheimer's who have biomarker evidence of disease.

  Recruiting Phase 2 Massachusetts General Hospital · Boston, Massachusetts · NCT07236190

• Spatial navigation training using immersive VR in older adults with mild cognitive impairment

  This trial tests whether older adults with mild cognitive impairment can complete a 24-session immersive VR navigation training and whether EEG together with VR can show brain activation changes during learning.

  Recruiting at 2 sites Albert Einstein College of Medicine · Manhattan, New York and 1 other locations · NCT07225400

• InRAD international registry for Alzheimer's disease and related dementias

  This project will collect routine medical information over time to see how Alzheimer's disease, mild cognitive impairment, and related dementias progress and how current treatments are tolerated in adults.

  Recruiting at 23 sites Stichting International Registry for Alzheimer's Disease and other Dementias Foundation · Melbourne and 22 other locations · NCT07213700

• Accelerated deep TMS to boost memory and thinking in older adults with mild memory problems

  We will test whether a short, intensive course of deep transcranial magnetic stimulation to the anterior cingulate plus online cognitive training can improve memory and thinking in people aged 55–85 with mild cognitive impairment or subjective memory decline.

  Recruiting Rotman Research Institute at Baycrest · Toronto, Ontario · NCT07212504

• Loneliness linked to dementia risk in older adults with mild cognitive impairment

  This study will look to see if loneliness is associated with a higher chance of developing dementia within 12 months in people aged 70 and older who have mild cognitive impairment.

  Recruiting Consorci Sanitari de l'Alt Penedès i Garraf · Vilanova i la Geltrú, Barcelona · NCT07211945

• Inspiratory muscle training to try to improve thinking and physical function in mild cognitive impairment

  This project will try a targeted breathing (inspiratory muscle) training program to see if it helps thinking and physical abilities in people with mild cognitive impairment.

  Recruiting University of West Attica · Aigáleo, Attica · NCT07146373

• Memory support program for older Chinese American adults with mild cognitive impairment

  This project will test whether the Memory Support System helps Mandarin- and Cantonese-speaking Chinese American older adults with mild cognitive impairment manage everyday memory and thinking challenges.

  Recruiting Icahn School of Medicine at Mount Sinai · New York, New York · NCT07142499

• Smart-home sensors and AI to detect dementia-related daily activities

  This project will try smart-home sensors and artificial intelligence to detect daily activities linked to mild cognitive impairment or early dementia in adults aged 50 and older who live at home.

  Recruiting University of Missouri-Columbia · Columbia, Missouri · NCT07120347

• RICORDO digital cognitive rehabilitation program for older adults

  This project will test whether the RICORDO digital rehabilitation program can help people aged 65 and older with subjective memory complaints, mild cognitive impairment, or mild Alzheimer's dementia improve thinking skills and better manage their own health.

  Recruiting Fondazione Don Carlo Gnocchi ETS · Milan · NCT07064226

• KDS2010 for people with MCI or mild dementia due to Alzheimer's disease.

  This trial will test whether taking KDS2010 once daily for 24 weeks helps thinking and memory and is safe in people aged 50–85 who are amyloid-positive with MCI or mild Alzheimer's dementia.

  Recruiting at 8 sites Phase 2 NeuroBiogen Co., Ltd · Gwangju, Gwangju and 7 other locations · NCT07027072

• Support program for individuals with early-stage memory loss living alone

  This study is testing a support program for people aged 60 and older with early-stage memory loss who live alone, to see if it helps them feel better and manage their challenges through online group sessions and personalized support.

  Recruiting Arizona State University · Phoenix, Arizona · NCT06962111

• Impact of Medium-chain Fatty Acids on Mild Cognitive Impairment

  This study is testing whether adding medium-chain fatty acids to a Mediterranean diet can help improve thinking skills and sleep quality in people with mild cognitive impairment.

  Recruiting Azienda Ospedaliera SS. Antonio e Biagio e Cesare Arrigo di Alessandria · Alessandria, Piedmont · NCT06951932

• Creatine and weight training for older adults with mild cognitive impairment

  This study tests whether taking creatine, doing resistance training, or doing both can help memory, brain health, and physical function in older adults with mild cognitive impairment.

  Recruiting Western University, Canada · London, Ontario · NCT06948149

• Twice-daily digital exercises to improve working memory and control in older adults

  This study tests whether two different digital training apps, used about 25–45 minutes a day for up to eight weeks, can help older adults (including those with mild cognitive impairment) improve working memory and inhibitory control.

  Recruiting University of California, San Francisco · San Francisco, California · NCT06918704

• Using saliva and extracellular vesicles to diagnose neurodegenerative diseases

  This study is testing a new way to diagnose neurodegenerative diseases like Alzheimer's and Parkinson's by analyzing saliva samples to see if it can help identify these conditions earlier and tailor treatments for patients.

  Recruiting at 5 sites Fondazione Don Carlo Gnocchi ETS · Florence, FI and 4 other locations · NCT06869135

• Tai Chi for Older Adults with Cognitive Concerns

  This study tests if an 8-week Tai Chi program can help older adults with mild cognitive impairment and muscle loss improve their thinking skills and overall well-being.

  Recruiting Ohio University · Athens, Ohio · NCT06828926

• Mindfulness meditation for improving cognition in older adults

  This study is testing whether mindfulness meditation can help older adults, including those with mild cognitive impairment, improve their thinking, memory, and overall quality of life.

  Recruiting VA Boston Healthcare System · Boston, Massachusetts · NCT06792877

• Using brain stimulation to improve memory in people with mild cognitive impairment

  This study is testing if a type of brain stimulation can help improve memory and thinking skills in older adults with mild cognitive impairment.

  Recruiting Centre for Addiction and Mental Health · Toronto, Ontario · NCT06783283

• Validating an online cognitive assessment tool for older adults with cognitive issues

  This study is testing an online cognitive assessment tool to see if it can effectively help older adults with mild cognitive impairment or those recovering from depression track their brain health over time.

  Recruiting at 3 sites Centre for Addiction and Mental Health · Toronto, Ontario and 2 other locations · NCT06780917

• Enhancing cognitive abilities in older adults through agricultural activities

  This study is testing whether engaging older adults with mild cognitive impairment in hands-on farming activities can help improve their thinking skills and overall well-being.

  Recruiting at 2 sites Istituto Nazionale di Ricovero e Cura per Anziani · Ancona and 1 other locations · NCT06754202

• Observational study of early Alzheimer's patients treated with Lecanemab

  This study is testing if the drug Lecanemab is safe and effective for people with early Alzheimer's disease and mild cognitive impairment.

  Recruiting Second Affiliated Hospital, Zhejiang University, School of Medicine · Hangzhou, Zhejiang · NCT06741553

• Memory training program for people with early memory problems

  This study is testing if a memory training program can help people with early memory problems feel better and improve their memory while also looking at a blood marker related to Alzheimer's disease.

  Recruiting St. Joseph's Hospital and Medical Center, Phoenix · Phoenix, Arizona · NCT06734286

• Validation of Italian cognitive assessment scales for elderly patients

  This study is trying to see if new Italian versions of cognitive and daily living assessments can help doctors better diagnose neurodegenerative diseases in older Italian-speaking patients.

  Recruiting Casa di Cura IGEA · Milan, Michigan · NCT06701630

• Improving sleep in older adults with mild cognitive impairment using brain stimulation and CBT-I

  This trial will try combining gentle transcranial magnetic stimulation (TMS) with cognitive behavioral therapy for insomnia (CBT-I) to improve sleep in people aged 60 and older who have mild cognitive impairment or subjective cognitive decline.

  Recruiting Beth Israel Deaconess Medical Center · Boston, Massachusetts · NCT06687161

• Probiotic formula to see if it helps mild cognitive impairment

  A probiotic supplement is being tried to see if it can help cognitive function in people aged 60–85 with mild cognitive impairment.

  Recruiting Universidad Complutense de Madrid · Madrid, Madrid and 1 other locations · NCT06670807

• Improving sleep quality to enhance memory in older adults with mild cognitive impairment

  This study is testing whether using special sounds during sleep can help older adults with mild memory problems sleep better and improve their memory over time.

  Recruiting University of Bern · Bern · NCT06669546

• Improving symptoms of mild cognitive impairment and early dementia with brain stimulation

  This study is testing a new brain stimulation treatment combined with mental exercises to see if it can help people with mild cognitive impairment and early dementia feel better.

  Recruiting University of Campania Luigi Vanvitelli · Caserta, Italy · NCT06668610

• Digital solutions for early treatment of cognitive disabilities in chronic neurological diseases

  This study is testing a digital brain training program to see if it helps people with Mild Cognitive Impairment, subjective cognitive complaints, or Parkinson's Disease improve their thinking skills compared to a different type of brain activity.

  Recruiting at 3 sites IRCCS Centro San Giovanni di Dio Fatebenefratelli · Brescia, IT and 2 other locations · NCT06657274

• Cognitive training using crossword puzzles for mild cognitive impairment

  This study is testing whether doing more crossword puzzles can help people with mild cognitive impairment think better compared to doing fewer puzzles or just learning about health.

  Recruiting at 4 sites Phase 2 Columbia University · Miami, Florida and 3 other locations · NCT06601933

• Time-restricted eating for adults with mild cognitive impairment

  This study is testing if a time-restricted eating plan can help improve brain function and health in adults aged 60-80 with mild cognitive impairment.

  Recruiting St. Joseph's Hospital and Medical Center, Phoenix · Phoenix, Arizona and 1 other locations · NCT06429124

• Investigating brain mechanisms for cognitive assessment and rehabilitation in cognitive decline

  This study is testing different ways to improve thinking skills in people with mild cognitive decline by looking at brain activity and trying out activities like training, exercise, and games.

  Recruiting National Research Center for Rehabilitation Technical Aids · Beijing, Beijing Municipality · NCT05014893

• Genetic factors in early-onset dementia

  This study is trying to find out how genetics might affect the risk and progression of early-onset dementia by looking at people with dementia, their families, and healthy individuals.

  Recruiting Columbia University · New York, New York · NCT04906863

• Exploring the effects of sleep and exercise on Alzheimer's risk

  This study is testing how good sleep and regular exercise might lower the risk of developing Alzheimer's disease over time.

  Recruiting University of Miami · Miami, Florida · NCT04855630

• Comprehensive assessment of neurodegeneration and dementia

  This project will collect brain scans, cognitive tests, and biological samples over time to see how dementia and related conditions progress in adults aged 50–90, including people with Parkinson's and people without cognitive problems.

  Recruiting at 11 sites McGill University · Calgary, Alberta and 18 other locations · NCT03402919

NIH-funded research (6)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Using a Conversational AI to Help Older Adults Prevent Falls at Home

  A small, practical project uses a chat-based AI coach to help people 65 and older follow proven steps to prevent falls, including those with mild cognitive impairment.

  NIH research Friendi.fi Corporation · Millbrae, United States · NIH-11418945

• Technology to support thinking and social life for older adults with mild cognitive impairment

  A multi-site program is developing an adaptive software to help older adults with mild cognitive impairment stay sharp, manage daily tasks, and stay socially connected.

  NIH research Weill Medical Coll of Cornell Univ · New York, United States · NIH-11377274

• How everyday relationships affect memory and dementia risk in diverse twins

  A long-term study in ethnically diverse twins explores how everyday social experiences, like loneliness or warmth from others, relate to mild cognitive impairment and the risk of Alzheimer’s disease.

  NIH research University of Minnesota · Minneapolis, United States · NIH-11374908

• AI conversational coach to deliver STEADI fall-prevention for older adults with and without mild cognitive impairment

  An easy-to-use virtual coach will guide older adults, including those with mild memory problems, through the CDC's STEADI fall-prevention steps to help reduce falls and keep people safer at home.

  NIH research Friendi.fi Corporation · Millbrae, United States · NIH-11370764

• Understanding how difficult social experiences affect memory and dementia risk in diverse twins

  This project looks at how challenging social experiences might influence memory problems and the risk for Alzheimer's and related dementias in a diverse group of twins.

  NIH research University of Minnesota · Minneapolis, United States · NIH-11128644

• Technology for Thinking Skills and Social Connections in Older Adults with Mild Cognitive Impairment

  This project aims to create and test smart software that helps older adults with mild memory problems improve their daily activities and stay connected with others.

  NIH research Weill Medical Coll of Cornell Univ · New York, United States · NIH-11105858

Related topics

Quick answers

How many Mild Cognitive Impairment (MCI) clinical trials are recruiting right now?

79, as of November 12, 2026. 4 of them were first registered in the last 30 days. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 26 countries. The most sites are in United States (29 trials), China (14 trials), Italy (14 trials), Canada (5 trials), Greece (4 trials). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2: 5, Phase 3: 1, Phase 1/2: 1, Phase 1: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

A list is a starting point. Tell us your situation in your own words and we'll rank the studies that match and explain why. It's free and needs no account.

Describe your situation →