Mapping the anterior temporal lobe in patients with drug-resistant epilepsy

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study focuses on patients with drug-resistant anterior temporal lobe epilepsy, which is a common form of focal epilepsy. It aims to utilize functional MRI techniques to accurately map the anterior temporal lobe before surgical intervention, specifically anterior temporal lobectomy. The mapping is crucial for identifying the epileptic focus while minimizing the risk of neurological and cognitive deficits post-surgery. The study also includes healthy volunteers for comparison purposes.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Adult person,
* Person affiliated to a social security scheme or beneficiary of such a scheme,
* Person having received complete information on the organization of the Clinical Investigation and having signed informed consent,
* Person having carried out a preliminary clinical examination adapted to the Clinical Investigation,
* For patients: Person with drug-resistant structural focal epilepsy of the anterior temporal lobe (right or left), candidate for epilepsy surgery (anterior temporal lobectomy),
* For healthy volunteers: Person with no known pathology in the anterior temporal lobe (particularly epilepsy).

Exclusion Criteria:

* Contraindication to MRI including claustrophobia,
* Uncorrected visual disturbances,
* Person unable to give consent,
* Lack of mastery of the French language or ability to understand instructions,
* Person referred to in Articles 64, 65 and 66 of European Regulation 2017/745: Person of full age unable to consent alone to participate in the Clinical Investigation; Minor; Pregnant or breastfeeding woman.

Where it's running

• Centre Hospitalier Régional Universitaire de Nancy
  Nancy, France Recruiting

Study contacts

• Study coordinator: Jacques JONAS
• Email: j.jonas@chru-nancy.fr
• Phone: +33383852377

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.