Attenuating Depression with Internet CBT to Slow Cognitive Decline in Older ICU Survivors
Official title: ADEPT-ICU: Attenuating Depression with Internet Cognitive Behavioral Therapy (CBT) to Slow Cognitive Decline in Older Intensive Care Unit (ICU) Survivors
Funded at Indiana University Indianapolis · NIH-11397007 · Data updated 2026-11-12
A new online cognitive behavioral therapy program is being tested to help older ICU survivors who are experiencing depressive symptoms and may be at risk for cognitive decline.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Indiana University Indianapolis NIH-funded |
| Lab location | 1 site (Indianapolis, United States) |
| Project start | August 15, 2024 |
| Project end | June 30, 2029 |
| Funding year | 2026 |
| Award (this year) | $731,627 |
| NIH project number | 5R01AG084754-03 |
| Project ID | NIH-11397007 on NIH RePORTER |
Who could benefit from this research
✓Could help
Older ICU survivors with depressive symptoms or risk factors for ADRD who are willing to engage with an online therapy program.
✕Less likely to help
Patients without access to internet or who have cognitive impairment that precludes CBT participation may not benefit.
What this research studies
This project tests whether a web-based CBT program can reduce depressive symptoms and slow subjective cognitive decline in adults aged 21 and older who survived an ICU stay. It uses a two-arm randomized controlled trial design to compare the internet-based CBT against a comparison condition. If successful, the intervention could be scaled to reach more older adults who have survived critical illness and are at risk for ADRD.
Why it matters
Potential benefit: If successful, patients could experience fewer depressive symptoms and slower cognitive decline after ICU survival.
How similar studies have gone: Previous work suggests psychotherapy can improve mood and may influence cognitive outcomes in related populations, but this specific internet CBT approach in older ICU survivors with depression is being tested.
Where this research is happening
-
Indiana University Indianapolis
Indianapolis, United States Active
Researchers
- Principal investigator: Khan, Babar a — Indiana University Indianapolis
- Study coordinator: Khan, Babar a
Related research
Other NIH-funded projects on the same topics.
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Internet CBT to reduce depression and memory decline after an ICU stay
This project offers online cognitive behavioral therapy to help reduce depression and slow thinking and memory problems in older adults who survived an intensive care unit stay.
-
Using online therapy to help older ICU survivors with depression and cognitive decline
This study is looking at whether online therapy can help older adults who have been in intensive care feel better mentally and improve their thinking skills, especially focusing on those from different backgrounds.
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A NICU-based program to screen newborns and families for social needs and connect them to services that can improve health and development.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.