Combining 40Hz light therapy with cognitive training for Alzheimer's treatment

An Observational Trial of Alzheimer's Disease Treatment With Combination of 40Hz Light and Cognitive Therapy

Alzheimer's Light LLC · NCT03657745

This study is testing whether using a special iPad app that combines 40Hz light therapy with brain exercises can help improve thinking and daily life for people with Alzheimer's disease.

Quick facts

Study typeObservational
Enrollment2000 (estimated)
Ages50 Years and up
SexAll
SponsorAlzheimer's Light LLC (industry)
Locations1 site (Miami, Florida)
Trial IDNCT03657745 on ClinicalTrials.gov

What this trial studies

This study investigates the effects of a novel iPad app that delivers 40Hz light therapy combined with cognitive therapy on patients with Alzheimer's disease and cognitive impairment. The approach is based on recent findings that exposure to flickering light can enhance gamma brainwave activity, potentially aiding in the clearance of beta amyloid plaques associated with Alzheimer's. Participants will engage in daily sessions of light therapy and cognitive exercises to assess improvements in cognition, function, and overall quality of life. The study aims to evaluate the effectiveness of this combined intervention in a real-world setting.

Who should consider this trial

Good fit: Ideal candidates for this study are individuals diagnosed with Alzheimer's disease or mild cognitive impairment.

Not a fit: Patients with a history of epileptic seizures or significant eye diseases may not benefit from this study.

Why it matters

Potential benefit: If successful, this approach could significantly improve cognitive function and quality of life for patients with Alzheimer's disease.

How similar studies have performed: Previous studies have shown promising results with similar light therapy approaches, indicating potential for success in this novel application.

Eligibility criteria

Show full inclusion / exclusion criteria
Inclusion Criteria:

* Alzheimer's disease
* Cognitive Impairment

Exclusion Criteria:

* any previously noted epileptic seizures, including febrile seizures.
* any significant disease of the eye, such as macular degeneration. Since the 40Hz light therapy is delivered via eye stimulation, healthy eyes are required.

Where this trial is running

Miami, Florida

Study contacts

How to participate

  1. Review the eligibility criteria above with your treating physician.
  2. Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
  3. Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.

View on ClinicalTrials.gov →

Conditions: Alzheimer Disease, Mild Cognitive Impairment, Dementia, Cognition Disorders in Old Age, Cognitive Decline, Cognitive Deterioration, Alzheimer's

Last reviewed 2026-05-15 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.