Exploring the link between blood pressure and cognitive decline after stroke
Association Between Blood Pressure and the Risk of Post-stroke Cognitive Impairment: a Retrospective Cohort Study
This study looks at how blood pressure levels might affect thinking and memory problems in people who have had a stroke.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 600 (estimated) |
| Ages | 18 Years to 90 Years |
| Sex | All |
| Sponsor | First Affiliated Hospital of Chongqing Medical University Academic / other |
| Locations | 1 site (Chongqing, Chongqing Municipality) |
| Trial ID | NCT06730711 on ClinicalTrials.gov |
What this trial studies
This observational study investigates the relationship between blood pressure levels and cognitive impairment in patients who have experienced a stroke. It includes patients who have been monitored for over three months post-stroke, collecting data on various factors that may influence cognitive outcomes. The study employs univariate and multivariate regression analyses to assess how blood pressure correlates with the risk of cognitive decline, with subgroup analyses to evaluate effects across different patient demographics.
Who should consider this trial
Good fit: Ideal candidates are patients diagnosed with stroke who have completed cognitive assessments and have been followed for more than three months.
Not a fit: Patients with pre-existing cognitive impairment or those who cannot complete cognitive assessments due to language or other barriers may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could provide insights into managing blood pressure to mitigate cognitive decline in stroke survivors.
How similar studies have performed: While the relationship between blood pressure and cognitive outcomes has been explored in other studies, this specific observational approach focusing on post-stroke patients is relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion criteria: 1. Patient diagnosed with stroke by CT or MRI, 2. Patients completed the MMSE scale at least once during hospitalization 3. The follow-up time was more than three months after the stroke occurred; Exclusion criteria: 1. Patients with incomplete data, follow-up time less than three months after the stroke occurred less than 3 months, 2. Patients with pre-existing cognitive impairment before stroke according to their medical records, 3. patients failed to complete MMSE assessment because of aphasia or any other reasons, 4. Patients combined with malignant tumors, patients combined with psychiatric disorders.
Where this trial is running
Chongqing, Chongqing Municipality
- First Affiliated Hospital of Chongqing Medical University — Chongqing, Chongqing Municipality, China (Recruiting)
Study contacts
- Study coordinator: Dingqun Bai
- Email: baidingqun@hospital.cqmu.edu.cn
- Phone: 13808380876
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.