Assessing sleep and circadian rhythms in older adults after major orthopedic surgery

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to identify sleep and circadian biomarkers associated with postoperative delirium in older adults undergoing major orthopedic surgery. Participants will wear an actigraphy watch to monitor their sleep patterns and provide blood samples for analysis of Alzheimer's disease pathology and inflammation. The study will also evaluate how these biomarkers relate to cognitive decline and the risk of delirium post-surgery. Follow-up assessments will occur remotely at 1, 3, and 12 months after surgery to gather additional data on cognitive function and sleep.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Age \>= 70 years old
* Scheduled to undergo major orthopedic surgery
* Expected postoperative recovery of more than 24 hours as an inpatient

Exclusion Criteria:

* Cognitive impairment leading to inability to consent
* Patients with limited mobility or inability to wear an actigraphy watch
* Patients with infection at the site of actigraphy watch, allergies to materials of watch
* Patients with \> two days in the ICU during the month prior to surgery
* Renal or liver failure
* Severe neurocognitive damage or history of psychiatric illness
* Blindness or deafness
* Patients who are non-English speaking

Where it's running

• Massachusetts General Hospital
  Boston, Massachusetts, United States Recruiting

Study contacts

• Principal investigator: Kun Hu, PhD — Massachusetts General Hospital
• Study coordinator: Lena Choe, BA
• Email: lchoe@bwh.harvard.edu
• Phone: 909-703-7537

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• China HEAD: a large community study on healthy aging and dementia

  This study tests whether collecting health, imaging, and biospecimen data from adults in China can help predict who will develop Alzheimer’s disease and related dementias.

  Recruiting at 30 sites Fudan University · Beijing and 29 other locations · NCT07912710

• Personalized iPad audio messages to reduce confusion after hip fracture surgery

  This trial will try 2-minute personalized audio reorientation messages on an iPad to see if they help prevent confusion (delirium) in people aged 60 and over after hip fracture surgery.

  Recruiting Sengkang General Hospital · Singapore · NCT07396532

• Feasibility of a Smartphone App to Support Mental Well-Being for Older Adults and Caregivers

  This pilot test checks whether the utmbHealthyBrain app can be used in community settings by adults 50+ and their caregivers to support mood and social connection over six weeks.

  Recruiting The University of Texas Medical Branch, Galveston · Galveston, Texas · NCT07313540

• Lifestyle intervention for older adults at risk of dementia

  This study is testing a personalized lifestyle program to see if it can help older adults at risk of dementia improve their brain health over a year.

  Recruiting Maastricht University Medical Center · Amsterdam and 1 other locations · NCT06832761

• Using brain stimulation and digital training to improve cognitive function in older adults

  This study is testing whether a combination of brain stimulation and digital training can help improve thinking skills in older adults with Mild Cognitive Impairment and Alzheimer's Disease.

  Recruiting Universidade Federal do Rio de Janeiro · Rio de Janeiro, Rio de Janeiro · NCT06733714

• Effects of different anesthesia techniques on cognitive function in elderly hip fracture patients

  This study tests different anesthesia methods to see which one helps older patients with hip fractures keep their thinking skills sharp during and after surgery.

  Recruiting at 8 sites Second Affiliated Hospital of Wenzhou Medical University · Dongyang, Zhejiang and 12 other locations · NCT06452147

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.