Metacognitive Strategy Help for Parkinson’s-Related Thinking Difficulties
Official title: Efficacy and Mechanisms of a Metacognitive Strategy Intervention for Parkinson disease-related Cognitive Decline
Funded at Washington University · NIH-11399024 · Data updated 2026-11-12
Aimed at people with Parkinson’s disease who have thinking and memory challenges, this project tests a practical, everyday strategy approach to help with daily tasks and improve quality of life.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Washington University NIH-funded |
| Lab location | 1 site (Saint Louis, United States) |
| Project start | September 1, 2025 |
| Project end | August 31, 2030 |
| Funding year | 2026 |
| Award (this year) | $763,015 |
| NIH project number | 5R01AG094871-02 |
| Project ID | NIH-11399024 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults with Parkinson’s disease who experience cognitive decline and related daily-function difficulties.
✕Less likely to help
People without Parkinson’s-related cognitive issues or those unable to participate in behavioral training may not benefit.
What this research studies
If you have Parkinson’s and experience cognitive difficulties, this study tests a strategy-based program called Multicontext to help you use practical tricks in daily activities. The researchers will guide participants through training that teaches generalizable strategies to cope with thinking and memory problems, with emphasis on applying them to real-life tasks. The study will compare outcomes to see if this approach reduces disability and helps people stay engaged in work, home duties, and social roles. Participation may involve cognitive training sessions and assessments of daily functioning over time. The aim is to translate cognitive support into meaningful improvements in day-to-day life for people living with PD.
Why it matters
Potential benefit: If successful, the program could help people with PD think more clearly and perform daily activities more independently.
How similar studies have gone: Strategy-based cognitive rehabilitation is standard in other brain injuries but is being tested here for PD with promising potential.
Where this research is happening
-
Washington University
Saint Louis, United States Active
Researchers
- Principal investigator: Foster, Erin — Washington University
- Study coordinator: Foster, Erin
Related research
Other NIH-funded projects on the same topics.
-
Improving memory function in people with Parkinson's disease
This study is all about helping people with Parkinson's disease who are having trouble with memory and daily tasks by teaching them practical tips they can use in their everyday lives to feel more confident and improve their quality of life.
-
Improving memory function in people with Parkinson's disease-related cognitive decline
This study is all about helping people with Parkinson's disease who are having trouble remembering daily tasks by teaching them new strategies to manage their activities better, so they can enjoy life more and possibly slow down memory issues.
-
How COVID-19 infection and genes may influence memory and dementia risk
This study looks at how getting COVID-19 and a person’s genes together affect the chance of developing memory problems and Alzheimer’s disease later in life.
-
NGF Metabolism as a biomarker for cognitive decline in familial Alzheimer's disease
Researchers are studying whether patterns in nerve growth factor pathways in blood and CSF can signal early, preclinical stages of Alzheimer's in people with genetic risk.
-
NGF metabolism as an early biomarker for cognitive decline in familial Alzheimer's disease
This project tests whether NGF pathway proteins in blood and CSF can signal early, preclinical changes in people with familial Alzheimer’s disease.
-
NGF Metabolic Dysfunction as a Marker of Cognitive Decline in Autosomal Dominant Alzheimer's Disease
This project looks at nerve growth factor pathways in people with a genetic form of Alzheimer's to see if blood and spinal fluid markers can identify early brain changes before symptoms appear.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.