See if cognitive impairment is common in older adults admitted for non-neurological rehab

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This multicenter, prospective study screens adults 45 years and older admitted for non-neurological conditions to cardiac, pulmonary, or orthopedic rehab units for cognitive impairment. Those with positive screening undergo extended neuropsychological testing, blood biomarker analysis, APOE genotyping, a non-contrast brain CT, and multimodal neurophysiological assessments. The goal is to determine the prevalence of cognitive impairment and to describe the clinical and demographic profiles of those affected, with secondary aims to identify cases not previously documented. The study emphasizes systematic cognitive screening in rehabilitation settings to better understand how cognitive deficits relate to recovery and outcomes.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Age ≥45 years
* Hospitalization for at least 7-10 days for a non-neurological condition, in cardiac, pulmonary, or orthopedic intensive rehabilitation units, or intermediate care units
* Adequate fluency in the Italian language
* Provision of written informed consent

Exclusion Criteria:

* Illiteracy
* Severe, uncorrected visual impairment and/or hearing loss
* Severe verbal communication deficit
* Inability to remain seated for the duration of the assessment
* Inability to use the dominant upper limb
* Altered state of consciousness or alertness (e.g., delirium)
* Severe scalp skin lesions or dermatitis precluding electrode application for neurophysiological recordings
* Previous or current history of severe psychiatric disorders (e.g., psychotic disorders, bipolar disorder, severe major depressive disorder with psychotic symptoms, current suicidal risk, or other psychiatric conditions judged by the investigator to interfere with study participation, procedural compliance, or interpretation of results)
* Previous history or current presence of clinically relevant neurological pathologies other than cognitive impairment (e.g., epilepsy, stroke, neurodegenerative diseases such as Parkinson's disease or multiple sclerosis, moderate-to-severe traumatic brain injury, brain tumors, central nervous system infections, or other neurological conditions that may influence cognitive, behavioral, or neurological functioning, or otherwise compromise the study objectives)

Where it's running

• IRCCS Fondazione Don Gnocchi ETS
  Florence, Fi, Italy Recruiting
• IRCCS Fondazione Don Carlo Gnocchi ETS, Santa Maria Nascente
  Milan, Michigan, Italy Recruiting
• Fondazione Don Carlo Gnocchi ETS, Istituto Palazzolo
  Milan, Michigan, Italy Recruiting

Study contacts

• Principal investigator: Cristina Polito — IRCCS Fondazione Don Carlo Gnocchi ETS, Firenze
• Study coordinator: Cristina Polito
• Email: crpolito@dongnocchi.it
• Phone: +390557393653

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.