Clinical trial Recruiting at 1 site Interventional Ages 60 to 85

Personalized program to prevent frailty and cognitive decline

Official title: Precision Care Pathway Through Frailty and Cognitive Assessment Among Older Adults and Development of Care4Senior App, Intensive Aerobic Resistance Training and Brain Health Program in the Community

Run by National University of Singapore · NCT07081282 · Data updated 2026-11-12

This 12-week program will try a mobile app combined with weekly group aerobic/resistance exercise and cognitive activities to help adults aged 60–85 with chronic diseases prevent frailty and cognitive decline.

Quick facts

Study typeInterventional
Ages60 Years to 85 Years
SexAll
Enrollment252 (estimated)
SponsorNational University of Singapore
Academic / other
Locations1 site (Singapore)
StatusRecruiting
StartedJuly 1, 2025
Main results expectedJanuary 31, 2027
Study endsMay 31, 2027
Registry record updatedJuly 23, 2025
Trial IDNCT07081282 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates are community-dwelling adults aged 60–85 with at least one chronic disease who can communicate in English or Mandarin and can use a smartphone and attend weekly sessions.

Probably not a fit

People with severe vision or hearing impairment, diagnosed severe cognitive impairment (such as dementia), or severe psychiatric disorders are unlikely to benefit from this program.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

Participants will use the Care4Seniors 2.0 mobile application for guided physical and cognitive exercises and attend weekly in-person group exercise and cognitive sessions at community centres. The intervention combines intensive aerobic and resistance training with brain-health activities and lifestyle support to reduce frailty risk and social isolation. The program targets community-dwelling older adults with at least one chronic disease and is delivered over 12 weeks. Outcomes will focus on physical function, cognitive measures, and measures of social bonding and isolation.

Why it matters

Potential benefit: If successful, the program could slow or prevent frailty and cognitive decline while improving social connection and self-management in older adults.

How similar studies have gone: Similar multimodal programs combining exercise and cognitive training, sometimes supported by digital tools, have shown modest improvements in physical function and cognition in older adults, although results across studies are variable.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

1. Older Adults Aged 60 to 85 years old
2. Living in the community
3. Formally diagnosed with at least one chronic disease
4. Able to communicate in either English or Mandarin

Exclusion Criteria:

1. Severe vision or hearing impairment
2. Diagnosed with severe cognitive impairment (e.g. dementia)
3. Diagnosed with severe psychiatric disorders (e.g. psychotic disorders, major depressive disorder)

Where it's running

  • Active Ageing Centres Under Changi General Hospital's Community Health Team Cluster (East Region)
    Singapore, Singapore
    Recruiting

Study contacts

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How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.