Integrated treatment to help adolescents recover from substance use disorders

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This clinical trial involves 294 adolescents aged 14-21 with substance use disorders, specifically alcohol and cannabis use disorders. It compares two psychosocial interventions: Integrated Treatment for Enhancing Growth in Recovery During Adolescence (InTEGRA), which combines 12-Step Facilitation with Motivational Enhancement Therapy/Cognitive Behavioral Therapy, against the standard MET/CBT alone. Participants are recruited from clinical settings and the community in Massachusetts and Connecticut, and are randomized to treatment conditions. Follow-up assessments occur every three months for one year after treatment completion to evaluate outcomes.

Why it matters

Who can join: the full rules

Inclusion criteria:

1. 14-21 years old
2. SUD based on criteria from the Diagnostic and Statistical Manual of Mental Disorders, 5th Edition (DSM-5)
3. able to read and comprehend English at a 5th-grade level
4. residence in Eastern time zone states (Connecticut, Delaware, Florida, Georgia, Indiana, Kentucky, Maine, Maryland, Massachusetts, Michigan, New Hampshire, New Jersey, New York, North Carolina, Ohio, Pennsylvania, Rhode Island, South Carolina, Tennessee, Vermont, Virginia, and West Virginia
5. any AOD use in the past 90 days (or in the 90 days prior to being in a controlled environment)
6. meet patient placement criteria for level I (outpatient) treatment
7. participant and a family member/guardian responsible for providing collateral information (for those \<18 years) agree to sign Institutional Review Board (IRB)-approved consent
8. participant and family member responsible for providing collateral information who could be contacted in case the subject became lost to follow-up.

Exclusion criteria:

1. suicidal ideation with a plan, suicidal behavior, a plan to hurt oneself or others, or a history of self-injurious behavior occurring in past 30 days
2. lifetime diagnosis of schizophrenia
3. current health condition (i.e., medical, psychiatric) that compromises participant's ability to attend outpatient treatment
4. demonstrate inability or unwillingness to identify a "locator" who could be contacted in case participant becomes lost to follow-up; or
5. youth attending another SUD treatment program or receiving psychotherapy that could conflict with study treatments.

Where it's running

• UConn Health
  Farmington, Connecticut, United States Recruiting
• MGH Department of Psychiatry
  Boston, Massachusetts, United States Recruiting

Study contacts

• Principal investigator: John F Kelly, PhD — Massachusetts General Hospital
• Study coordinator: Alexandra W Abry, BA
• Email: aabry@mgh.harvard.edu
• Phone: 617-724-5259

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.