Social cognition in severe alcohol use disorder

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This interventional study examines the neural basis of social cognition deficits in people with severe alcohol use disorder (SAUD) using psychometric tests of emotion recognition and theory of mind, paired with MRI. It aims to see how brain structure differences correlate with social-cognitive performance and whether sex and tobacco use influence these relationships. Participants are adults aged 18-65,Native French speakers, in treatment and abstinent, with SAUD, recruited from CHU de Reims and affiliated institutions. The study focuses on understanding everyday social functioning and the neurobiology underlying SAUD-related social deficits to inform future interventions.

Why it matters

Who can join: the full rules

1. AUD patients

   Inclusion criteria:
   * Patients between 18 and 65 years old, men or women, right-handed, following AUD treatment as inpatients or outpatients and currently abstinent
   * Having a diagnosis of severe alcohol use disorder according to DSM-5 criteria
   * Native French speakers
   * Patients enrolled in the national healthcare insurance program
   * Patients consenting to participate in the study

   Exclusion criteria:
   * A diagnosis of schizophrenia, of any other chronic psychotic state, or of bipolar disorder according to DSM-5 criteria
   * The presence of a current depressive episode as defined by DSM-5 criteria
   * The presence of another moderate or severe substance use disorder according to DSM-5 criteria, except for tobacco and cannabis if alcohol is the primary substance consumed and the criteria for cannabis dependence are not met
   * The presence of a neurodevelopmental disorder
   * The presence of any clinically significant or unstable pathology: organic pathology affecting the central nervous system or disease likely to interfere with assessments, including the neurological complications of alcoholism
   * Having any uncorrected auditory or visual deficits
   * Contraindication to the use of MRI
   * Individuals particularly protected by the law
   * No smartphone with Apple or Android operating system
2. Healthy control participants:

Inclusion criteria:

* Participants between 18 and 65 years old, men or women, right-handed
* Native French speakers
* Participants enrolled in the national healthcare insurance program
* Participants consenting to participate in the study

Exclusion criteria:

* A diagnosis of schizophrenia, of any other chronic psychotic state, or of bipolar disorder according to DSM-5 criteria
* The presence of a current depressive episode as defined by DSM-5 criteria
* The presence of substance use disorder as defined by DSM-5 diagnostic criteria, except for tobacco dependence
* Having any first-degree relative with alcohol use disorder according to DSM-5 diagnostic criteria
* The presence of a neurodevelopmental disorder
* The presence of any clinically significant or unstable pathology: organic pathology affecting the central nervous system
* Having any uncorrected auditory or visual deficits
* Contraindication to the use of MRI
* Individuals particularly protected by the law
* No smartphone with Apple or Android operating system

Where it's running

• Chu Reims
  Reims, Reims, France Recruiting

Study contacts

• Study coordinator: Franca Schmid
• Email: franca.schmid1@univ-reims.fr
• Phone: 03 26 61 19 30

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.