Non-hallucinogenic psilocybin derivative for alcohol use disorder
Official title: Characterization of a novel non-hallucinogenic psilocybin derivative for alcohol use disorder
Funded at Terp Life, LLC · NIH-11594445 · Data updated 2026-11-12
A new, safer psilocybin-like compound is being studied to help people with alcohol use disorder.
Quick facts
| Grant type | Sbir 2 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Terp Life, LLC NIH-funded |
| Lab location | 1 site (Tampa, United States) |
| Project start | September 15, 2025 |
| Project end | August 31, 2028 |
| Funding year | 2026 |
| Award (this year) | $1,027,734 |
| NIH project number | 4R44AA031925-02 |
| Project ID | NIH-11594445 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates are adults with alcohol use disorder who are able to participate in research and comply with study procedures.
✕Less likely to help
Individuals without alcohol use disorder or with contraindications to serotonergic agents may not benefit.
What this research studies
This project aims to develop and test a non-hallucinogenic psilocybin derivative that targets serotonin receptors, with the goal of reducing alcohol-use behaviors. Researchers will analyze how these molecules interact with 5-HT2A receptors and related pathways, focusing on achieving therapeutic effects without psychedelic symptoms. The study plans to move from animal models showing preliminary efficacy to plans for human-facing research, emphasizing safety and reduced abuse potential.
Why it matters
Potential benefit: If successful, this could lead to a new treatment option that helps people reduce or stop drinking with fewer side effects.
How similar studies have gone: Prior work suggests serotonergic compounds can influence alcohol-related behaviors, but a non-hallucinogenic derivative with strong efficacy and safety requires further validation.
Where this research is happening
-
Terp Life, LLC
Tampa, United States Active
Researchers
- Principal investigator: Salm, Jacqueline — Terp Life, LLC
- Study coordinator: Salm, Jacqueline
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.