Using repetitive TMS to improve thinking skills in people with alcohol use disorder

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study investigates the effects of high-frequency repetitive transcranial magnetic stimulation (rTMS) on improving executive functions in individuals with alcohol use disorder (AUD) who have been abstinent for a period of time. The research aims to address cognitive impairments associated with AUD, particularly focusing on cognitive flexibility, which is crucial for adaptive behavior. Participants will undergo rTMS treatment while their cognitive functions are assessed to determine the efficacy of this intervention in enhancing their mental capabilities. The study is conducted at a specialized facility in Querétaro, Mexico.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Men and women of 25 to 59 years old
* The reading level of at least 6th grade of primary (equivalent to fifth grade of elementary school).
* Alcohol users with and AUDIT ≥ 20 puntos
* Abstinence from alcohol consumption from 8 weeks to 5 years, with CIWA-Ar scale scores ≤ 9 points.
* No disabling neuropsychiatric conditions (i.e. Schizophrenia)
* No substance use disorders except alcohol and nicotine.
* BrAC (Breath Alcohol) = 0.00 mg/dl in each of the assessments.
* No traces of alcohol consumption using urine test strips.
* No contraindications for TMS therapy.

Exclusion Criteria:

* Individuals with symptoms of severe agitation or who are unable to cooperate in the study
* History of epilepsy
* Sudden onset of stroke, focal neurological findings such as hemiparesis, sensory loss, visual field deficits and lack of coordination.
* Seizures or gait disturbances
* History of severe psychiatric disorders.
* Alterations in a conventional electroencephalogram.
* Pacemakers or intracranial metallic objects.

Elimination criteria

* At the subject's request
* The presence of adverse incidents that deteriorate the subject's health and would limit continuation of rTMS treatment.
* Exacerbation of cognitive or behavioral symptoms during treatment.

Where it's running

• Unidad de Resonancia Magnética
  Querétaro City, Querétaro, Mexico Recruiting

Study contacts

• Principal investigator: Eduardo A Garza-Villarreal, MD, PhD — Universidad Nacional Autonoma de Mexico
• Study coordinator: Alejandra Lopez Castro, MD, MSc
• Email: alejandraloc@comunidad.unam.mx
• Phone: +524422381038

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.