Examining how cannabis affects alcohol consumption
Official title: Cannabis' Impact on Alcohol Consumption: Integrating Laboratory and Ecological Momentary Assessment Methods
Run by Brown University · NCT05389930 · Data updated 2026-11-12
This study is testing how different types of cannabis affect drinking habits in heavy drinkers who use cannabis regularly.
Quick facts
| Phase | Phase 2 |
|---|---|
| Study type | Interventional |
| Ages | 21 Years to 50 Years |
| Sex | All |
| Enrollment | 350 (estimated) |
| Sponsor | Brown University Academic / other |
| Locations | 1 site (Providence, Rhode Island) |
| Status | Recruiting |
| Started | March 16, 2023 |
| Main results expected | August 31, 2027 |
| Study ends | December 31, 2027 |
| Registry record updated | October 5, 2026 |
| Trial ID | NCT05389930 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are English-speaking adults aged 21 to 50 who are heavy episodic drinkers and have used cannabis in the past two months.
✕Probably not a fit
Patients who are pregnant, nursing, or seeking treatment for alcohol or cannabis use may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This study investigates the effects of THC-dominant and CBD-dominant cannabis on alcohol consumption among heavy episodic drinkers who use cannabis weekly. Participants will engage in an alcohol choice task where they can choose to drink or receive monetary rewards for abstaining from alcohol. The study will enroll up to 350 participants, with a focus on understanding the impact of specific cannabinoids and the context of cannabis-alcohol co-use. Data will be collected through a combination of experimental sessions and a smartphone application over a four-week period.
Why it matters
Potential benefit: If successful, this study could provide insights into effective strategies for reducing alcohol consumption among heavy drinkers using cannabis.
How similar studies have gone: Other studies have explored the relationship between cannabis and alcohol use, but this specific approach examining the effects of different cannabinoid profiles is relatively novel.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Age 21 to 50 * English-speaking * cannabis smoking in past two months * heavy drinking in past two months * in good physical health and weighing \< 250 lbs * zero breath alcohol at each visit Exclusion Criteria: * positive pregnancy test * nursing * positive urine toxicology screen for drugs other than cannabis * interest to quit or receive treatment for cannabis or alcohol use
Where it's running
-
Brown University
Providence, Rhode Island, United States Recruiting
Study contacts
- Principal investigator: Jane Metrik, PhD — Brown University
- Study coordinator: Jane Metrik, PhD
- Email: Jane_Metrik@brown.edu
- Phone: 401-863-6650
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.