Clinical trial Recruiting at 1 site Phase 2 Interventional Ages 21 to 50

Examining how cannabis affects alcohol consumption

Official title: Cannabis' Impact on Alcohol Consumption: Integrating Laboratory and Ecological Momentary Assessment Methods

Run by Brown University · NCT05389930 · Data updated 2026-11-12

This study is testing how different types of cannabis affect drinking habits in heavy drinkers who use cannabis regularly.

Quick facts

PhasePhase 2
Study typeInterventional
Ages21 Years to 50 Years
SexAll
Enrollment350 (estimated)
SponsorBrown University
Academic / other
Locations1 site (Providence, Rhode Island)
StatusRecruiting
StartedMarch 16, 2023
Main results expectedAugust 31, 2027
Study endsDecember 31, 2027
Registry record updatedOctober 5, 2026
Trial IDNCT05389930 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates are English-speaking adults aged 21 to 50 who are heavy episodic drinkers and have used cannabis in the past two months.

Probably not a fit

Patients who are pregnant, nursing, or seeking treatment for alcohol or cannabis use may not benefit from this study.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study investigates the effects of THC-dominant and CBD-dominant cannabis on alcohol consumption among heavy episodic drinkers who use cannabis weekly. Participants will engage in an alcohol choice task where they can choose to drink or receive monetary rewards for abstaining from alcohol. The study will enroll up to 350 participants, with a focus on understanding the impact of specific cannabinoids and the context of cannabis-alcohol co-use. Data will be collected through a combination of experimental sessions and a smartphone application over a four-week period.

Why it matters

Potential benefit: If successful, this study could provide insights into effective strategies for reducing alcohol consumption among heavy drinkers using cannabis.

How similar studies have gone: Other studies have explored the relationship between cannabis and alcohol use, but this specific approach examining the effects of different cannabinoid profiles is relatively novel.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* Age 21 to 50
* English-speaking
* cannabis smoking in past two months
* heavy drinking in past two months
* in good physical health and weighing \< 250 lbs
* zero breath alcohol at each visit

Exclusion Criteria:

* positive pregnancy test
* nursing
* positive urine toxicology screen for drugs other than cannabis
* interest to quit or receive treatment for cannabis or alcohol use

Where it's running

  • Brown University
    Providence, Rhode Island, United States
    Recruiting

Study contacts

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.