Liver health check plus brief alcohol support for hospitalized adults

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

Adults admitted to 8 Norwegian hospitals who drink at risky levels and have signs of possible liver fibrosis will be randomized to receive liver elastography with tailored brief alcohol intervention or to usual care. Elastography provides a quick liver health assessment at bedside, enabling immediate feedback and personalized counseling about reducing alcohol use. Participants will be followed after discharge at 3, 6, and 12 months to track self-reported drinking, a biomarker (PEth), and quality of life. The study aims to determine whether proactive liver assessment combined with targeted counseling can lower future alcohol-related harm and hospital readmissions. Recruitment targets 500 participants over 18 months.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Emergency hospitalized for any reason in any participating centre
2. Adults 18 years or older
3. Harmful alcohol use, defined as AUDIT-C ≥6 (for men) or AUDIT-C ≥5 (for women)
4. Moderate to high risk of liver fibrosis, defined as FIB-4 \>1.3
5. Signed informed consent

Exclusion Criteria:

1. Decompensated liver disease that impedes intervention delivery, defined as one or more of the following:

   1. Moderate or severe ascites
   2. Overt hepatic encephalopathy (West Haven grade ≥2)
   3. Acute-on-chronic liver failure requiring admission to intensive care unit
2. Acute hepatitis of any aetiology, defined as ALT or AST \>5 x upper limit of normal (ULN)
3. Unable to participate for any reason in the opinion of the investigator

Where it's running

• Oslo University Hospital
  Oslo, Norway Recruiting
• Haraldsplass Deaconess Hospital
  Bergen, Norway Not yet recruiting
• Vestre Viken Bærum Hospital
  Drammen, Norway Not yet recruiting
• Sykehuset Nord-Trøndelag Levanger
  Levanger, Norway Not yet recruiting
• Sykehuset Innlandet Lillehammer
  Lillehammer, Norway Not yet recruiting
• Akershus University Hospital
  Lørenskog, Norway Not yet recruiting

Study contacts

• Principal investigator: Mette Vesterhus — Haraldsplass Deaconess Hospital, Bergen, Norway
• Study coordinator: Håvard Midgard, Professor
• Email: havardmi@gmail.com
• Phone: +47 908 30 071

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.