Condition

Addiction clinical trials and research

• 21Clinical trials
• 277NIH research projects
• 1New in 30 days
• 5Countries

Newest Addiction clinical trials

All recruiting trials (21)

• Vocal Signals of Craving in Addiction

  Researchers will see if voice patterns can signal craving in adults with addictions by having them perform voice tasks and report their cravings in real time.

  Recruiting University of Bordeaux · Bordeaux · NCT07878624

• Impact of GLP-1 Receptor Agonist Therapy vs Structured Lifestyle on Weight and Health

  This study tests whether starting a GLP-1 receptor agonist for weight loss works differently from a structured diet-and-exercise program in improving heart and metabolic health for adults with overweight or obesity.

  Recruiting Texas Tech University · Lubbock, Texas · NCT07740291

• Craving and addiction severity: how craving links to changing levels of addiction in daily life

  This observational study tests whether craving and the way different addiction symptoms interact can predict changes in addiction severity over two years for adults with substance use disorders.

  Recruiting University of Bordeaux · Bordeaux · NCT07734363

• Mobile phone use restriction and PET imaging of dopamine transporter

  This study tests how restricting daily mobile phone use for two weeks affects dopamine transporter binding in healthy iPhone users who can use the Screentime app.

  Recruiting Pusan National University Hospital · Busan, Busan · NCT07663474

• STAR Project: Supporting Recovery for People with Criminal Legal System Involvement

  A new coaching program tests whether paired Recovery Coach and Loved One Coach sessions help people in recovery from substance use and their supporters see better recovery outcomes.

  Recruiting University of Kentucky · Lexington, Kentucky · NCT07596251

• NLP-based weekly writings to track mood and worry during residential rehab for SUD

  This study tests whether weekly Spanish narratives and biweekly questionnaires can reveal patterns of mood and thoughts that relate to recovery in adults with substance use disorders in a Mexican rehab center.

  Recruiting Under The Tree Therapeutic Community · Potrerillos, Jalisco · NCT07595614

• Comparative evaluation of nicotine analogs for nicotine EC users

  This early-stage trial tests whether two nicotine-like compounds (6-MN and nicotinamide) differ from nicotine in how they feel, how much people use them, and how they affect the body in adult e-cigarette users.

  Recruiting Phase 1 Ohio State University Comprehensive Cancer Center · Columbus, Ohio · NCT07585006

• Brain imaging to predict teens' response to cannabis treatment

  This project will test whether teens' brain activity during a learning task can predict how well 14–17-year-olds do in a 10-week virtual reward program to reduce cannabis use.

  Recruiting Indiana University · Indianapolis, Indiana · NCT07340554

• Long-term outcomes for people getting treatment for addiction

  This project will follow people starting treatment for substance or behavioral addictions to see how they do over time.

  Recruiting Centre Hospitalier Charles Perrens, Bordeaux · Bordeaux, Gironde · NCT07249970

• ECCCLORE group program for people with addiction and trauma-related PTSD

  This program will try a group-based ECCCLORE therapy to see if it helps people who have addiction and PTSD or complex PTSD reduce substance use and impulsive or hostile behaviors.

  Recruiting Centre Hospitalier Universitaire de Nīmes · Nîmes, Nîmes · NCT07193914

• Using deep brain stimulation to treat severe addiction

  This study is testing if deep brain stimulation can help people with severe addiction who haven't found success with other treatments.

  Recruiting Centre for Addiction and Mental Health · Toronto, Ontario · NCT06973512

• Using tDCS (mild brain stimulation) to reduce vaping

  This project will try daily transcranial direct current stimulation (tDCS) to reduce cravings and vaping in adults who use nicotine e-cigarettes every day and are not planning to quit.

  Recruiting Centre for Addiction and Mental Health · Toronto, Ontario · NCT06885606

• Long-term high-dose lisdexamfetamine treatment for methamphetamine use disorder

  This trial will try giving adults with moderate to severe methamphetamine use disorder a 25-week course of high-dose lisdexamfetamine plus their usual care to see if it helps them stay in treatment and cut down on methamphetamine use compared with placebo.

  Recruiting Phase 2 Centre hospitalier de l'Université de Montréal (CHUM) · Montreal, Quebec · NCT06788587

• Motivational interviews to help maintain abstinence after alcohol withdrawal

  This study tests if using motivational interviews as extra support can help adults who have just gone through alcohol withdrawal stay sober longer compared to regular care.

  Recruiting University Hospital, Montpellier · Montpellier · NCT06618755

• Neuroprotective treatment for patients with substance addiction

  This study is testing whether a treatment made from pomegranate seed oil can help people with substance addiction improve their brain health and thinking skills while they are in recovery.

  Recruiting Distribuidora Biolife SA de CV · Guadalajara, Jalisco · NCT06550167

• Syringe-service telemedicine plus social-network HIV prevention program

  This program will test whether training people who inject drugs to recruit and educate their peers through syringe service telemedicine and social networks increases HIV testing and use of prevention and treatment services in Maryland.

  Recruiting Johns Hopkins University · Baltimore, Maryland and 1 other locations · NCT06103370

• High dose stimulant treatment for methamphetamine users

  This study is testing whether a high dose of a medication called lisdexamfetamine, along with support and rewards, can help adults who use methamphetamine reduce their drug use more effectively than standard treatment alone.

  Recruiting at 3 sites Phase 2 Centre hospitalier de l'Université de Montréal (CHUM) · Vancouver, British Columbia and 3 other locations · NCT05854667

• Understanding Youth Addiction Services in France

  This study looks at how well the 'Consultations Jeunes Consommateurs' help young people with addiction issues in France and what their experiences are like.

  Recruiting Hôpital le Vinatier · Bron, Auvergne-Rhône-Alpes · NCT05609474

• Combining brain stimulation and cognitive training for alcohol use disorder

  This study is testing if combining brain stimulation with thinking exercises can help people with alcohol use disorder stay sober longer.

  Recruiting University of Minnesota · Minneapolis, Minnesota · NCT05062369

• Online parenting support program for families facing stressors

  This study is testing an online version of a parenting support program to help families facing stress from issues like depression and domestic violence, especially during COVID-19.

  Recruiting University of Calgary · Calgary, Alberta · NCT04857775

• Using a smartphone app to help manage cravings in people with addictions

  This study tests whether a smartphone app can help people with addictions manage their cravings and reduce their substance use.

  Recruiting Centre Hospitalier Charles Perrens, Bordeaux · Bordeaux · NCT04732676

NIH-funded research (newest 40 of 277)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Reducing Addiction Risk in High Schools Through Better Prevention Infrastructure

  Aims to build a sustainable, school-based system to prevent opioid and other drug use among high school students, especially those at higher risk.

  NIH research Washington University · Saint Louis, United States · NIH-11582595

• HEAL Data Platform to share addiction-related data across programs

  A platform project to make HEAL data from many programs easier to find and use, helping researchers and clinicians access information about addiction in children and youth.

  NIH research University of Chicago · Chicago, United States · NIH-11580283

• Cognitively-enhanced tDCS to reduce cocaine craving

  A study to test whether real brain stimulation together with learning strategies can lessen craving in people with cocaine use disorder.

  NIH research Icahn School of Medicine at Mount Sinai · New York, United States · NIH-11550899

• Yale center researching how tobacco products affect use and addiction in people

  A Yale research center is studying how nicotine, flavor additives, and other ingredients in tobacco products influence people’s likelihood of starting and becoming addicted.

  NIH research Yale University · New Haven, United States · NIH-11533172

• Atherosclerosis in cocaine addiction: imaging risk with PET/MR

  This project uses PET/MR imaging to look for early artery disease in people with cocaine use disorder to help prevent strokes or other brain injuries.

  NIH research Icahn School of Medicine at Mount Sinai · New York, United States · NIH-11520916

• Integrating long-acting PrEP into street medicine for people who use drugs

  This project tests whether a long-acting HIV prevention shot (lenacapavir) can be feasibly and acceptably offered by street-based health teams to people who use drugs.

  NIH research University of Washington · Seattle, United States · NIH-11469899

• New statistical methods to study brain networks in substance use and addiction

  A small, focused project will develop and test new brain-imaging analysis methods to identify biomarkers linked to substance use risk and addiction, using resting-state MRI data from people with autistic disorder.

  NIH research William D Shannon Consulting, LLC · St Louis, UNITED STATES · NIH-11455092

• Prenatal alcohol exposure may raise risk for postnatal addiction

  This grant looks at how drinking during pregnancy could make someone more likely to develop addiction later and what brain signals drive that risk, with a focus on the brain’s reward system.

  NIH research Indiana University Indianapolis · Indianapolis, United States · NIH-11449913

• Understanding how low-nicotine cigarettes affect beliefs and smoking behavior

  This grant tests how people understand nicotine versus burning tobacco and whether education about low-nicotine cigarettes changes their beliefs and smoking choices.

  NIH research Rutgers Biomedical and Health Sciences · Newark, UNITED STATES · NIH-11449008

• Mindfulness-based digital aftercare to support addiction recovery

  A digital mindfulness program delivered via a smartphone app to help adults stay sober after intensive addiction treatment.

  NIH research Yale University · New Haven, United States · NIH-11443402

• HNSCC, iron addiction, and potential iron-targeted therapies

  This grant explores how head and neck cancer cells become dependent on iron and whether targeting iron pathways could lead to new treatments for patients with recurrent or metastatic disease.

  NIH research Virginia Commonwealth University · Richmond, United States · NIH-11441057

• Real-world patient and clinician preferences to improve prenatal care for women with OUD and HCV

  Researchers are exploring how pregnant women with opioid use disorder and hepatitis C, along with their clinicians, would like to receive care to improve outcomes for moms and babies.

  NIH research Boston Medical Center · Boston, United States · NIH-11432865

• Polysubstance Addiction Research Center (PARC)

  A center at UC San Diego uses advanced AI and diverse rat models to study how multiple drugs interact in addiction and how this relates to human brain and body data, aiming to improve treatments for substance use disorders.

  NIH research University of California, San Diego · La Jolla, United States · NIH-11422452

• Understanding how cocaine changes specific brain cells and circuits to drive addiction

  A larger study at Duke University will explore how cocaine changes certain brain cells and circuits, with the goal of finding fresh ways to help people struggling with addiction.

  NIH research Duke University · Durham, United States · NIH-11422384

• Modeling how nicotine addiction develops in youth and its future impact

  A program at the University of Michigan plans to use a computer model to understand how teens and young adults become addicted to nicotine and what might happen in the future under different regulations.

  NIH research University of Michigan at Ann Arbor · Ann Arbor, United States · NIH-11421857

• Police pathways to treatment and safety for people who use drugs

  A study in two U.S. cities explores police-assisted diversion to connect people who use drugs with treatment and services instead of arrest.

  NIH research Rhode Island Hospital · Providence, United States · NIH-11417277

• Intersecting Addiction and Disability Services – Alcohol

  This grant explores how alcohol use and access to treatment differ for adults with disabilities compared with those without disabilities.

  NIH research Brandeis University · Waltham, United States · NIH-11413465

• Supportive workplace changes to keep residential addiction treatment workers and patients cared for

  A large study in Massachusetts tests a participatory program to improve working conditions for residential addiction treatment staff, with the goal of keeping workers on the job and improving patient care.

  NIH research Boston College · Chestnut Hill, United States · NIH-11401225

• Precise platform to guide addiction therapies targeting brain signals

  A new platform aims to precisely control brain signaling to better treat cocaine addiction and related CNS disorders.

  NIH research Vanderbilt University · Nashville, UNITED STATES · NIH-11400342

• Center for Addiction and Disease Risk Exacerbation (CADRE)

  A multidisciplinary center at Brown University studies how substance use affects chronic disease risk and outcomes in kids and young people, with plans to track people over time to develop targeted prevention and intervention strategies.

  NIH research Brown University · Providence, United States · NIH-11400077

• Penn State tobacco product toxicity and addiction research hub

  A center-based effort to understand how tobacco product aerosols and oxidants affect health and addiction, with the goal of guiding safer regulations.

  NIH research Pennsylvania State Univ Hershey Med Ctr · Hershey, United States · NIH-11394435

• Effects of e-cigarettes, nicotine pouches, menthol and nicotine on adults’ smoking and addiction

  This grant tests how different non-cigarette products and their ingredients affect smoking behavior in adults who currently smoke.

  NIH research Yale University · New Haven, United States · NIH-11394369

• Understanding how new e-cigarette flavors and additives affect appeal and potential dependence

  Researchers at Yale are studying how synthetic coolant and nicotine in e-cig liquids influence how appealing they are and how likely they are to cause continued use among adult vapers.

  NIH research Yale University · New Haven, United States · NIH-11394362

• Tobacco products and addiction research at Yale

  A Yale-led project is studying how nicotine, flavors, and other additives in tobacco products affect how teens and adults start using tobacco and become addicted, with goals to inform FDA rules.

  NIH research Yale University · New Haven, United States · NIH-11394341

• DNA breaks and repair in opioid addiction

  This project looks at how DNA damage and repair in brain cells may influence opioid addiction and relapse in people and animal models.

  NIH research University of Kansas Lawrence · Lawrence, United States · NIH-11393755

• Center for Systems Neurogenetics of Addiction (CSNA)

  A research center is studying how genetic and brain factors influence cocaine addiction, using mouse models and human genetics to understand why some people are more prone to drug seeking.

  NIH research Jackson Laboratory · Bar Harbor, United States · NIH-11389620

• Lineage Addiction in Prostate Cancer: Molecular Interactions and Biomarker Clues

  This grant explores how advanced prostate cancer that no longer fully responds to standard therapy might be driven by specific molecular changes and biomarkers, aiming to inform better treatment sequencing for American men.

  NIH research University of Wisconsin-Madison · Madison, United States · NIH-11389350

• Understanding how sugar fuels pancreatic cancer spread

  Researchers are studying how pancreatic cancer cells use sugar to power the spread of tumors, especially to the liver, with the goal of finding new ways to stop deadly metastasis.

  NIH research University of Miami School of Medicine · Coral Gables, United States · NIH-11385443

• Predicting overdoses in Los Angeles County using a rapid, public dashboard to target street-based care

  A rapid dashboard will help identify overdose hotspots in Los Angeles County so street-based teams can target treatment and harm-reduction services for people at risk.

  NIH research University of California Los Angeles · Los Angeles, United States · NIH-11381615

• Community support network to strengthen addiction care in Vietnam

  This project builds community health worker and family support networks to help people with opioid use disorder in three regions of Vietnam access and stay in treatment.

  NIH research University of California Los Angeles · Los Angeles, United States · NIH-11378863

• Avatar-guided digital CBT for people with addiction

  This compares an online, self-guided CBT program that uses a virtual avatar with standard CBT for people seeking help for substance use and related partner‑violence issues.

  NIH research University of Rochester · Rochester, United States · NIH-11378622

• Adaptive decision support to improve opioid treatment in ED care

  A flexible, computer-based tool helps emergency departments start evidence-based buprenorphine treatment for people with opioid use disorder.

  NIH research Yale University · New Haven, United States · NIH-11378360

• Neurobehavioral effects of childhood brain injuries and addiction risk in twins

  This grant studies how mild traumatic brain injury in childhood might influence behavior and the chance of developing addictive behaviors later in life, using twins to understand what’s due to injury versus other factors.

  NIH research Washington University · Saint Louis, United States · NIH-11377341

• Addiction risk and flavor ideas in concept-flavored cigarillos

  This project looks at how concept flavor labels on cigarillos might influence addiction risk and appeal among young adults, especially Black and Hispanic communities.

  NIH research University of Oklahoma Hlth Sciences Ctr · Oklahoma City, United States · NIH-11376516

• Delivery of addiction treatment for Medicaid enrollees with injection-related infections

  This project studies how treating addiction in hospital patients with serious injections-related infections affects their health and costs, using Medicaid data.

  NIH research Weill Medical Coll of Cornell Univ · New York, United States · NIH-11374400

• Genetic and Epigenetic Drivers of Cocaine Addiction in Brain Cells

  This grant studies how genes and their chemical markings change in the brain after cocaine use, using mice to understand why addiction develops.

  NIH research University of Chicago · Chicago, United States · NIH-11372847

• Epigenomic maps of brain cells to understand opioid addiction in teens and adults

  This study looks at how genes and environment shape brain changes in people exposed to opioids, from adolescence into adulthood.

  NIH research Virginia Polytechnic Inst and St Univ · Blacksburg, United States · NIH-11372109

• THC and CBD for opioid addiction and chronic pain

  This project seeks to reduce both chronic pain and opioid cravings in people with opioid use disorder who are receiving opioid agonist therapy by using a combination of THC and CBD.

  NIH research Yale University · New Haven, United States · NIH-11371353

• Telehealth tDCS for Cannabis Addiction Recovery (CARES)

  A home-based, telehealth program uses noninvasive brain stimulation plus mindfulness to help adults reduce cannabis use and curb cannabis use disorder.

  NIH research New York University School of Medicine · New York, United States · NIH-11371195

• Smartphones for Opioid Addiction Recovery

  This project is creating a smartphone tool to help people with Opioid Use Disorder stay on track with their treatment by predicting when they might be at risk of using opioids again.

  NIH research New York University School of Medicine · New York, United States · NIH-11370780

Related topics

Quick answers

How many Addiction clinical trials are recruiting right now?

21, as of November 12, 2026. 1 of them was first registered in the last 30 days. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 5 countries. The most sites are in France (7 trials), United States (6 trials), Canada (5 trials), Mexico (2 trials), South Korea (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2: 2, Phase 1: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

A list is a starting point. Tell us your situation in your own words and we'll rank the studies that match and explain why. It's free and needs no account.

Describe your situation →