Condition

Alcoholism clinical trials and research

• 20Clinical trials
• 12NIH research projects
• 11Countries

Newest Alcoholism clinical trials

All recruiting trials (20)

• Long-term mental health tracking for medical students

  This project will try to find what makes medical students more likely to develop depression by following cohorts of first-year health students over time and comparing them with peers who did not progress to the second year.

  Recruiting Centre Hospitalier Régional d'Orléans · Orléans, Loiret · NCT07305701

• BrainsWay Deep Transcranial Magnetic Stimulation (Deep TMS) for adults with alcohol use disorder

  This study will test whether BrainsWay Deep TMS can reduce heavy drinking in adults with moderate to severe alcohol use disorder compared with a sham procedure.

  Recruiting at 9 sites Brainsway · Tuscaloosa, Alabama and 10 other locations · NCT07216872

• How alcohol changes the social brain during paired interactions

  This study tests whether drinking alcohol changes brain activity and social bonding during conversations between pairs of regular social drinkers aged 21–30.

  Recruiting University of Illinois at Urbana-Champaign · Champaign, Illinois and 1 other locations · NCT07125534

• Ketamine plus real-time fMRI neurofeedback for alcohol use disorder

  This trial will test whether ketamine combined with real-time fMRI neurofeedback helps adults with alcohol use disorder drink less.

  Recruiting Phase 2 Psychiatric University Hospital, Zurich · Zurich · NCT06969937

• Tirzepatide's effects on alcohol intake in patients with schizophrenia and alcohol use disorder

  This study is testing if the medication tirzepatide can help people with schizophrenia and alcohol use disorder drink less alcohol over six months.

  Recruiting at 2 sites Phase 2 Psychiatric Centre Rigshospitalet · Aalborg, Denmark and 1 other locations · NCT06939088

• Comparing two therapies for alcohol addiction

  This study is testing which therapy, Combined Behavioral Intervention or Ericksonian Hypnotherapy, works better to help adults with alcohol addiction reduce their drinking and improve their overall well-being.

  Recruiting Beykoz University · Istanbul · NCT06916754

• Cannabidiol plus naltrexone for reducing alcohol craving in adults with alcohol dependence

  This trial will test whether adding cannabidiol (CBD) to naltrexone, or using CBD alone, reduces alcohol craving in adults with alcohol dependence.

  Recruiting Phase 2 Central Institute of Mental Health, Mannheim · Wiesloch, Baden-Wurttemberg and 1 other locations · NCT06845124

• Understanding habits and decision-making in alcohol use disorder

  This study is trying to understand how habits and decision-making affect people with Alcohol Use Disorder compared to those without it.

  Recruiting Technische Universität Dresden · Dresden · NCT06701500

• Investigating how Pavlovian mechanisms influence substance use behaviors

  This study is testing how certain learned responses might affect substance use behaviors in people with moderate to severe substance use disorders compared to healthy individuals.

  Recruiting Technische Universität Dresden · Dresden · NCT06701487

• Monitoring substance use and tracking relapse through smartphone data

  This study is testing a smartphone app to see how tracking people's phone use and habits can help understand and prevent drug and alcohol relapse in adults.

  Recruiting National Institutes of Health Clinical Center (CC) · Baltimore, Maryland · NCT06676059

• Referral to alcohol treatment for patients with liver disease

  This study tests whether sending newly diagnosed patients with alcohol-related liver disease to specialized treatment can help them stop drinking better than just regular care alone.

  Recruiting Zealand University Hospital · Køge, Køge · NCT06493773

• Functional connectivity–guided transcranial magnetic stimulation for alcohol use disorder

  This study will test whether a single fMRI-guided session of transcranial magnetic stimulation (TMS) can reduce alcohol-cue brain reactivity and help people with moderate-to-severe alcohol use disorder stay abstinent.

  Recruiting VA Palo Alto Health Care System · Palo Alto, California · NCT06415721

• Mobile health outreach for men's cancer screening

  This study is testing a mobile health service that brings cancer screening directly to men at their workplaces, especially those in high-risk groups, to help them get checked for prostate cancer and other urological issues.

  Recruiting Royal Marsden NHS Foundation Trust · London · NCT06357416

• Early intervention for alcohol and substance abuse in adolescents

  This study is testing if an online program can help teenagers aged 14-20 at a psychiatric clinic reduce their alcohol and substance use by checking in with them before and after six months.

  Recruiting Kuopio University Hospital · Kuopio · NCT06262958

• Using psilocybin with therapy to help reduce heavy drinking in people with alcohol use disorder

  This study is testing if a single dose of psilocybin, along with therapy, can help people with alcohol use disorder drink less over 12 weeks.

  Recruiting Phase 2 University of Calgary · Calgary, Alberta · NCT05995769

• Evaluating liver disease screening for individuals with alcohol use disorder

  This study tests if screening for liver disease with a special measurement helps people in alcohol treatment stay sober or drink less over six months.

  Recruiting at 2 sites Zealand University Hospital · Køge and 1 other locations · NCT05855031

• Naltrexone treatment for heavy drinkers with Alcohol Use Disorder

  This study is testing if a long-acting injection of naltrexone can help heavy drinkers cut back on their alcohol use.

  Recruiting Phase 4 University of Pennsylvania · Philadelphia, Pennsylvania · NCT05028062

• Using high-frequency rTMS to help reduce alcohol consumption in patients with alcohol use disorder

  This study is testing whether a special brain treatment can help adults with alcohol use disorder drink less without needing to stop completely.

  Recruiting Centre Hospitalier Universitaire Dijon · Dijon · NCT04773691

• Understanding and reducing suicidal behavior in bipolar disorder patients

  This study is testing a 6-week group program with different therapies to see if it can help people with bipolar disorder reduce suicidal thoughts and improve their quality of life.

  Recruiting Emory University · Atlanta, Georgia · NCT02604277

• Using ketamine to treat major depression in patients with a family history of alcohol use disorder

  This study is testing if a single dose of ketamine can help people with treatment-resistant depression who have a family history of alcohol problems feel better.

  Recruiting Phase 2 University of Iowa · Iowa City, Iowa · NCT02122562

NIH-funded research (12)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• How a brain receptor links heavy drinking and depression

  This work tests whether blocking a brain receptor called NK1R can reduce stress-driven heavy drinking and depressive symptoms in people with both alcohol problems and depression.

  NIH research University of Georgia · Athens, United States · NIH-11400454

• Genes, brains, and life: understanding alcoholism through family-based genetics

  A large study of families explores how genes, brain biology, and life experiences interact to shape alcohol use, recovery, and relapse across the lifespan.

  NIH research Suny Downstate Medical Center · Brooklyn, United States · NIH-11398201

• How the brain's immune system affects alcoholism

  This project looks at how brain immune and inflammation systems contribute to heavy drinking and aims to find new treatment targets for people with alcohol use disorder.

  NIH research University of Texas at Austin · Austin, United States · NIH-11306624

• Testing new medications for alcohol dependence and related pain issues.

  This study is looking at new medications that might help people dealing with alcohol dependence and the emotional and pain issues that often come with it, so that one day, there could be better treatment options for those who need them.

  NIH research Lsu Health Sciences Center · New Orleans, United States · NIH-11218407

• Family genetics of alcohol use disorder

  This project looks at how genes, brain function, and life circumstances shape alcohol problems, recovery, and relapse in people from large families, with a new focus on those aged 40 and older.

  NIH research Suny Downstate Medical Center · Brooklyn, United States · NIH-11195688

• Mavoglurant's effects on brain reward and impulsivity in people with inherited risk for alcoholism

  This project gives mavoglurant and uses brain scans during reward and impulse-control tasks to see differences between people with and without a family history of alcoholism.

  NIH research Yale University · New Haven, United States · NIH-11127634

• Center developing brain-based treatments for alcohol use and addiction

  This project is trying a medication that targets the brain receptor mGluR5 to reduce heavy drinking and fix brain-circuit problems linked to alcoholism.

  NIH research Yale University · New Haven, United States · NIH-11127631

• Understanding Brain Changes from Alcohol Use and Aging

  This project explores how alcohol use disorder and aging together affect brain health and memory.

  NIH research Sri International · Menlo Park, United States · NIH-11088162

• Exploring how alcohol use affects brain function and Alzheimer's disease over time

  This study is looking at how drinking habits might affect brain health and the risk of developing Alzheimer's disease in people aged 50 and older, especially focusing on African Americans, to help us understand the links between alcohol use and changes in brain function.

  NIH research Washington University · Saint Louis, United States · NIH-10871862

• Developing new medications to help reduce alcohol dependence

  This study is looking for new medications that can help people reduce their drinking by targeting a specific enzyme in the brain, and if successful, these treatments could offer a safer option for those struggling with alcohol use disorder.

  NIH research University of California, San Diego · La Jolla, United States · NIH-10850909

• Understanding how alcoholism may lead to chronic pain.

  This study is looking at how drinking problems might affect pain in people recovering from alcoholism, and it hopes to find out if changes in the brain could help explain why some of these individuals experience chronic pain.

  NIH research Massachusetts General Hospital · Boston, United States · NIH-10816590

• Developing a new treatment for alcoholism using GPR88 agonists

  This study is working on new medications to help people with alcohol use disorders by focusing on a specific receptor in the brain that affects drinking behavior, aiming to create treatments that work better and have fewer side effects than what’s currently available.

  NIH research Research Triangle Institute · Research Triangle Park, United States · NIH-10459403

Related topics

Quick answers

How many Alcoholism clinical trials are recruiting right now?

20, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 11 countries. The most sites are in United States (7 trials), Germany (3 trials), Denmark (3 trials), France (2 trials), United Kingdom (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2: 5, Phase 4: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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