Clinical trial Recruiting at 1 site Interventional Ages 18 and up

Comparing early and standard liver transplant outcomes for alcohol use disorder treatment

Official title: Alcohol Treatment Outcomes Following Early vs. Standard Liver Transplant for Severe Alcoholic Hepatitis (SAH)

Run by Johns Hopkins University · NCT03845205 · Data updated 2026-11-12

This study tests whether a new combined treatment for alcohol use, offered both in-person and online, can help people who are getting a liver transplant due to alcohol-related liver disease do better after their surgery compared to standard care.

More Alcohol Use Disorder trials

Quick facts

Study typeInterventional
Ages18 Years and up
SexAll
Enrollment200 (estimated)
SponsorJohns Hopkins University
Academic / other
Locations1 site (Baltimore, Maryland)
StatusRecruiting
StartedNovember 20, 2020
Main results expectedJune 2027
Study endsJune 2027
Registry record updatedJune 9, 2026
Trial IDNCT03845205 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates for this study are English-speaking adults undergoing liver transplantation for alcoholic hepatitis.

Probably not a fit

Patients who are too medically or psychiatrically ill to participate or unable to provide informed consent due to cognitive impairment may not benefit from this study.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This clinical trial investigates the effectiveness of integrated alcohol treatment delivered both in-person and via computer for patients undergoing liver transplantation due to alcoholic hepatitis. It compares this approach to standard care in terms of alcohol use, mood, quality of life, and survival rates post-transplant. The study aims to identify predictors of alcohol outcomes 12 months after transplantation to enhance future treatment strategies. By focusing on post-transplant interventions, the trial addresses a critical gap in care for patients at high risk of relapse.

Why it matters

Potential benefit: If successful, this study could significantly reduce alcohol relapse rates and improve overall outcomes for liver transplant patients with alcohol use disorder.

How similar studies have gone: Previous studies have shown promise in using integrated alcohol treatment approaches, suggesting potential success for this trial's methodology.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* English speaking

Exclusion Criteria:

* too medically/psychiatrically ill to participate
* not able to provide informed consent due to cognitive impairment

Where it's running

  • Johns Hopkins University School of Medicine
    Baltimore, Maryland, United States
    Recruiting

Study contacts

  • Principal investigator: Mary E McCaul, PhD — Johns Hopkins University
  • Study coordinator: MARY E MCCAUL, PhD
  • Email: mmccaul1@jhmi.edu
  • Phone: 410-955-9526

Similar studies

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How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.