Comparing early and standard liver transplant outcomes for alcohol use disorder treatment
Official title: Alcohol Treatment Outcomes Following Early vs. Standard Liver Transplant for Severe Alcoholic Hepatitis (SAH)
Run by Johns Hopkins University · NCT03845205 · Data updated 2026-11-12
This study tests whether a new combined treatment for alcohol use, offered both in-person and online, can help people who are getting a liver transplant due to alcohol-related liver disease do better after their surgery compared to standard care.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 200 (estimated) |
| Sponsor | Johns Hopkins University Academic / other |
| Locations | 1 site (Baltimore, Maryland) |
| Status | Recruiting |
| Started | November 20, 2020 |
| Main results expected | June 2027 |
| Study ends | June 2027 |
| Registry record updated | June 9, 2026 |
| Trial ID | NCT03845205 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates for this study are English-speaking adults undergoing liver transplantation for alcoholic hepatitis.
✕Probably not a fit
Patients who are too medically or psychiatrically ill to participate or unable to provide informed consent due to cognitive impairment may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This clinical trial investigates the effectiveness of integrated alcohol treatment delivered both in-person and via computer for patients undergoing liver transplantation due to alcoholic hepatitis. It compares this approach to standard care in terms of alcohol use, mood, quality of life, and survival rates post-transplant. The study aims to identify predictors of alcohol outcomes 12 months after transplantation to enhance future treatment strategies. By focusing on post-transplant interventions, the trial addresses a critical gap in care for patients at high risk of relapse.
Why it matters
Potential benefit: If successful, this study could significantly reduce alcohol relapse rates and improve overall outcomes for liver transplant patients with alcohol use disorder.
How similar studies have gone: Previous studies have shown promise in using integrated alcohol treatment approaches, suggesting potential success for this trial's methodology.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * English speaking Exclusion Criteria: * too medically/psychiatrically ill to participate * not able to provide informed consent due to cognitive impairment
Where it's running
-
Johns Hopkins University School of Medicine
Baltimore, Maryland, United States Recruiting
Study contacts
- Principal investigator: Mary E McCaul, PhD — Johns Hopkins University
- Study coordinator: MARY E MCCAUL, PhD
- Email: mmccaul1@jhmi.edu
- Phone: 410-955-9526
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.