Comparing early and standard liver transplant outcomes for alcohol use disorder treatment
Alcohol Treatment Outcomes Following Early vs. Standard Liver Transplant for Severe Alcoholic Hepatitis (SAH)
This study tests whether a new combined treatment for alcohol use, offered both in-person and online, can help people who are getting a liver transplant due to alcohol-related liver disease do better after their surgery compared to standard care.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 200 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Johns Hopkins University Academic / other |
| Locations | 1 site (Baltimore, Maryland) |
| Trial ID | NCT03845205 on ClinicalTrials.gov |
What this trial studies
This clinical trial investigates the effectiveness of integrated alcohol treatment delivered both in-person and via computer for patients undergoing liver transplantation due to alcoholic hepatitis. It compares this approach to standard care in terms of alcohol use, mood, quality of life, and survival rates post-transplant. The study aims to identify predictors of alcohol outcomes 12 months after transplantation to enhance future treatment strategies. By focusing on post-transplant interventions, the trial addresses a critical gap in care for patients at high risk of relapse.
Who should consider this trial
Good fit: Ideal candidates for this study are English-speaking adults undergoing liver transplantation for alcoholic hepatitis.
Not a fit: Patients who are too medically or psychiatrically ill to participate or unable to provide informed consent due to cognitive impairment may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could significantly reduce alcohol relapse rates and improve overall outcomes for liver transplant patients with alcohol use disorder.
How similar studies have performed: Previous studies have shown promise in using integrated alcohol treatment approaches, suggesting potential success for this trial's methodology.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * English speaking Exclusion Criteria: * too medically/psychiatrically ill to participate * not able to provide informed consent due to cognitive impairment
Where this trial is running
Baltimore, Maryland
- Johns Hopkins University School of Medicine — Baltimore, Maryland, United States (Recruiting)
Study contacts
- Principal investigator: Mary E McCaul, PhD — Johns Hopkins University
- Study coordinator: MARY E MCCAUL, PhD
- Email: mmccaul1@jhmi.edu
- Phone: 410-955-9526
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.