Condition

Alcohol Abuse clinical trials and research

• 14Clinical trials
• 12NIH research projects
• 9Countries

Newest Alcohol Abuse clinical trials

All recruiting trials (14)

• Effects of comorbidity on people with severe mental illness

  This study tests how having both alcohol/substance use and a severe mental illness affects hospitalizations, medications, and social participation among adults followed at a mental health center.

  Recruiting Abant Izzet Baysal University · Bolu, Bolu · NCT07692984

• Transcutaneous auricular neurostimulation (tAN) for reducing alcohol withdrawal in people with alcohol use disorder

  This trial will try a five-day ear‑stimulation device (tAN) versus a sham device to reduce alcohol withdrawal symptoms in adults with moderate-to-severe alcohol use disorder.

  Recruiting Spark Biomedical, Inc. · Houston, Texas · NCT07281261

• BrainsWay Deep Transcranial Magnetic Stimulation (Deep TMS) for adults with alcohol use disorder

  This study will test whether BrainsWay Deep TMS can reduce heavy drinking in adults with moderate to severe alcohol use disorder compared with a sham procedure.

  Recruiting at 9 sites Brainsway · Tuscaloosa, Alabama and 10 other locations · NCT07216872

• Reducing alcohol use and improving HIV treatment for men in fishing communities

  This study is testing a new program to help men with HIV in fishing communities cut down on drinking and stick to their HIV treatment to improve their health.

  Recruiting San Diego State University · Kampala · NCT06771843

• Functional connectivity–guided transcranial magnetic stimulation for alcohol use disorder

  This study will test whether a single fMRI-guided session of transcranial magnetic stimulation (TMS) can reduce alcohol-cue brain reactivity and help people with moderate-to-severe alcohol use disorder stay abstinent.

  Recruiting VA Palo Alto Health Care System · Palo Alto, California · NCT06415721

• Psilocybin versus ketamine for reducing heavy drinking in alcohol use disorder

  This trial will test whether a single 30 mg dose of psilocybin or a weight-based 0.75 mg/kg dose of ketamine, each given with individual psychotherapy, can reduce heavy drinking in adults with moderate to severe alcohol use disorder.

  Recruiting Phase 2 University of Iowa · Iowa City, Iowa · NCT06405607

• Economic and relationship support to reduce alcohol use in Malawi

  This study is testing whether a program that helps couples in Malawi save money and learn relationship skills can reduce heavy drinking among people living with HIV.

  Recruiting University of California, San Francisco · Zomba · NCT06367348

• Telehealth program using blood tests to help treat alcohol use disorder

  This study is testing a new telehealth program that uses blood tests to help people with alcohol use disorder by combining online therapy with rewards for submitting their test results.

  Recruiting Washington State University · Spokane, Washington · NCT06265506

• Understanding how stress affects alcohol cravings and consumption

  This study is trying to see how stress affects cravings for alcohol in people who struggle with drinking by looking at their brain activity during different tasks.

  Recruiting Central Institute of Mental Health, Mannheim · Mannheim, Baden-Wurttemberg · NCT06247306

• Evaluating liver disease screening for individuals with alcohol use disorder

  This study tests if screening for liver disease with a special measurement helps people in alcohol treatment stay sober or drink less over six months.

  Recruiting at 2 sites Zealand University Hospital · Køge and 1 other locations · NCT05855031

• Bright Horizons program to reduce binge substance use in Native American adolescents

  This project will test whether the Bright Horizons program can help reduce binge drinking and other substance use in Native American teens aged 12–17 who live on or near the Fort Apache Reservation.

  Recruiting Johns Hopkins Bloomberg School of Public Health · Whiteriver, Arizona · NCT05743699

• Web-based intervention for military spouses to reduce alcohol use

  This study tests a new online program designed to help military spouses cut down on alcohol use and encourage their service member partners to seek help.

  Recruiting Stanford University · Palo Alto, California · NCT05619185

• Using simvastatin to treat liver fibrosis caused by alcohol

  This study tests if simvastatin, a cholesterol-lowering medication, can help people with liver damage from alcohol reduce their fibrosis.

  Recruiting Phase 2/3 Fundacion Clinic per a la Recerca Biomédica · Barcelona · NCT04971577

• Impact of Alcohol and Drugs on Immune Function in Critically Ill Patients with Lung Issues

  This study looks at how alcohol and drug use affects the immune system and recovery in critically ill patients with lung problems.

  Recruiting University of Colorado, Denver · Aurora, Colorado · NCT02299921

NIH-funded research (12)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Chronic alcohol use and sepsis: why outcomes worsen

  This project studies why people with alcohol use disorder have worse outcomes when they get sepsis, with findings that could guide personalized care.

  NIH research Emory University · Atlanta, United States · NIH-11400332

• Tracking HIV, alcohol use, and brain aging with MRI

  Aging people living with HIV who also have alcohol use disorder are being studied to understand how brain changes relate to balance, movement, and thinking over time using MRI.

  NIH research Sri International · Menlo Park, United States · NIH-11395398

• Insula–amygdala circuits and alcohol abuse

  This project studies how binge drinking changes brain circuits between the insula and amygdala to influence alcohol seeking and anxiety in a relevant animal model.

  NIH research Mclean Hospital · Belmont, United States · NIH-11393795

• How HIV and heavy drinking change the aging brain

  Researchers will use repeated brain scans and movement and thinking tests to find why people living with HIV—especially those with alcohol use disorder—may have faster declines in balance, walking, and cognition.

  NIH research Sri International · Menlo Park, United States · NIH-11168684

• How long-term heavy drinking changes sepsis outcomes

  This project looks at how chronic heavy drinking alters the gut barrier and immune responses in people with alcohol use disorder who develop sepsis.

  NIH research Emory University · Atlanta, United States · NIH-11160576

• Node of Ranvier in Alcohol Abuse

  A study exploring how alcohol affects brain wiring by looking at specific nerve fibers and the gaps between them in people and rats.

  NIH research University of Mississippi Med Ctr · Jackson, United States · NIH-11139779

• Investigating how alcohol abuse during late adolescence affects combat Veterans' health.

  This study looks at how heavy drinking during the teenage years might affect the health of veterans later on, especially in areas like decision-making and emotions, to help find better ways to prevent and treat issues like addiction, depression, and PTSD in those who served.

  NIH research Baltimore VA Medical Center · Baltimore, United States · NIH-11109729

• Understanding how trauma affects alcohol use in young people

  This study is looking at how experiencing trauma can affect young people aged 16 to 19 and increase their chances of having problems with alcohol, so we can find better ways to help those who might be at risk.

  NIH research Ohio State University · Columbus, UNITED STATES · NIH-11036406

• Understanding brain circuits involved in alcohol abuse

  This study looks at how binge drinking can change the way certain parts of the brain work together, which might affect feelings and behaviors related to alcohol use, helping us understand more about alcohol use disorder and anxiety.

  NIH research Mclean Hospital · Belmont, United States · NIH-10894279

• How brain cells respond to alcohol abuse

  This study looks at how binge drinking affects certain brain cells called astrocytes and how these changes might influence drinking habits, with the goal of finding new ways to help people who struggle with alcohol use.

  NIH research North Carolina Central University · Durham, United States · NIH-10883676

• How adolescent alcohol abuse affects stress and PTSD risk in adults

  This study is looking at how drinking alcohol as a teenager might affect your ability to handle stress and develop PTSD later in life, and it's for anyone interested in understanding the long-term effects of early alcohol use on mental health.

  NIH research Medical University of South Carolina · Charleston, United States · NIH-10758204

• Investigating how alcohol reinforcement affects drinking habits after weight loss surgery

  This study is looking at how changes in the urge to drink alcohol can affect people who have had weight loss surgery, and it aims to help understand why some of these patients might drink more after their surgery, so we can find ways to support them better.

  NIH research Sanford Research North · Fargo, United States · NIH-10705563

Related topics

Quick answers

How many Alcohol Abuse clinical trials are recruiting right now?

14, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 9 countries. The most sites are in United States (8 trials), Turkey (Türkiye) (1 trial), Uganda (1 trial), Denmark (1 trial), Germany (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2/3: 1, Phase 2: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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