Condition

Alcohol Dependence clinical trials and research

• 12Clinical trials
• 17NIH research projects
• 10Countries

Newest Alcohol Dependence clinical trials

All recruiting trials (12)

• BrainsWay Deep Transcranial Magnetic Stimulation (Deep TMS) for adults with alcohol use disorder

  This study will test whether BrainsWay Deep TMS can reduce heavy drinking in adults with moderate to severe alcohol use disorder compared with a sham procedure.

  Recruiting at 9 sites Brainsway · Tuscaloosa, Alabama and 10 other locations · NCT07216872

• Tirzepatide's effects on alcohol intake in patients with schizophrenia and alcohol use disorder

  This study is testing if the medication tirzepatide can help people with schizophrenia and alcohol use disorder drink less alcohol over six months.

  Recruiting at 2 sites Phase 2 Psychiatric Centre Rigshospitalet · Aalborg, Denmark and 1 other locations · NCT06939088

• Exploring the effects of heavy alcohol use on oral health and saliva

  This study is trying to see how heavy drinking affects oral health and inflammation in people with alcohol use disorder compared to those without it.

  Recruiting National Institutes of Health Clinical Center (CC) · Bethesda, Maryland · NCT06684483

• Validation of the French version of the PAWSS scale for alcohol withdrawal prediction

  This study is testing a French version of a scale to see if it can accurately predict alcohol withdrawal symptoms in people with alcohol use disorders who are in the hospital.

  Recruiting Etablissement Public de Santé Barthélemy Durand · Étampes · NCT06675539

• Psilocybin versus ketamine for reducing heavy drinking in alcohol use disorder

  This trial will test whether a single 30 mg dose of psilocybin or a weight-based 0.75 mg/kg dose of ketamine, each given with individual psychotherapy, can reduce heavy drinking in adults with moderate to severe alcohol use disorder.

  Recruiting Phase 2 University of Iowa · Iowa City, Iowa · NCT06405607

• Combining neuromodulation and mindfulness for alcohol dependence

  This study is testing if combining a special nerve stimulation technique with mindfulness meditation can help people recovering from alcohol dependence reduce cravings and improve their chances of staying sober.

  Recruiting Charite University, Berlin, Germany · Berlin, State of Berlin · NCT06308484

• Telehealth program using blood tests to help treat alcohol use disorder

  This study is testing a new telehealth program that uses blood tests to help people with alcohol use disorder by combining online therapy with rewards for submitting their test results.

  Recruiting Washington State University · Spokane, Washington · NCT06265506

• Early intervention for alcohol and substance abuse in adolescents

  This study is testing if an online program can help teenagers aged 14-20 at a psychiatric clinic reduce their alcohol and substance use by checking in with them before and after six months.

  Recruiting Kuopio University Hospital · Kuopio · NCT06262958

• High-dose theta burst stimulation for alcohol addiction treatment

  This study tests whether a new brain stimulation treatment can help people with alcohol addiction reduce their cravings and dependence on alcohol.

  Recruiting University of Regensburg · Regensburg · NCT05738174

• Assessing the safety and pharmacokinetics of IVL3004 and IVL4002 in healthy males

  This study is testing two new drugs, IVL3004 and IVL4002, in healthy men to see how safe they are and how the body absorbs them compared to an existing treatment for addiction.

  Recruiting Phase 1 Inventage Lab., Inc. · Herston, Queensland · NCT05620940

• Exploring the health journeys of older adults with alcohol-related issues

  This study looks at how older adults over 60 with alcohol-related problems do after being hospitalized, to see if short treatments help them better than younger people.

  Recruiting Helse Stavanger HF · Stavanger · NCT04164940

• Using fecal microbiota transplantation to treat gut disorders

  This study is testing whether a treatment that involves using healthy stool to help restore gut bacteria can improve symptoms for people with gut disorders like Crohn's disease and irritable bowel syndrome.

  Recruiting Chinese University of Hong Kong · Hong Kong, Shatin · NCT04014413

NIH-funded research (17)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Medial Prefrontal Cortex and Alcohol Relapse in Humans

  A study aims to understand brain factors in relapse to drinking alcohol after abstinence, focusing on the medial prefrontal cortex and blood-brain barrier changes in adults with alcohol use disorder.

  NIH research Veterans Medical Research Fdn/san Diego · San Diego, United States · NIH-11395370

• New GLT-1 Activators to Help People with Alcohol Dependence

  A new preclinical study tests novel drugs that boost a brain transporter to reduce drinking and relapse in alcohol-related conditions.

  NIH research University of Toledo Health Sci Campus · Toledo, United States · NIH-11380715

• Activation of PSTN CRF neurons and their role in alcohol drinking

  A study in mice explores how activating specific brain neurons in the parasubthalamic nucleus affects patterns of drinking and the motivation behind alcohol use.

  NIH research Scripps Research Institute, the · La Jolla, United States · NIH-11320627

• Mapping immune-related gene changes in the brains of people with alcohol dependence

  This project maps where and which brain cells show immune-related gene changes in people with alcohol dependence to point toward new treatment targets.

  NIH research University of Texas at Austin · Austin, United States · NIH-11296915

• Targeting brain support cells to curb heavy drinking and brain inflammation

  This project is testing whether lowering a specific enzyme in brain support cells (astrocytes) can curb heavy drinking and brain inflammation for people with alcohol dependence.

  NIH research Oregon Health & Science University · Portland, United States · NIH-11295399

• Frontal brain changes linked to alcohol relapse

  This work looks at how changes in a frontal brain area and blood–brain barrier problems may lead to relapse in adults with alcohol use disorder.

  NIH research Veterans Medical Research Fdn/san Diego · San Diego, United States · NIH-11166530

• Drugs that boost a brain glutamate transporter to reduce alcohol dependence

  Testing new compounds that increase a brain protein that clears glutamate to help people with alcohol dependence drink less and avoid relapse.

  NIH research University of Toledo Health Sci Campus · Toledo, United States · NIH-11098521

• Reducing alcohol cravings in people with alcohol dependence

  This research explores a new way to help people with alcohol dependence reduce their cravings and prevent relapse by modifying a common therapy.

  NIH research University of Texas at Austin · Austin, United States · NIH-11098466

• CBD for alcohol dependence: how it may calm the brain’s fear center

  A study tests whether cannabidiol (CBD) can help people with alcohol dependence by changing brain signals in the basolateral amygdala during withdrawal and after stopping drinking.

  NIH research University of California, San Diego · La Jolla, United States · NIH-11039612

• Investigating how brain cells respond to alcohol dependence

  This study is looking at how brain cells called astrocytes change when someone has an alcohol use disorder, and it hopes to find out if changing a specific gene can help reduce drinking and improve brain health.

  NIH research Oregon Health & Science University · Portland, United States · NIH-11014323

• Investigating how glucocorticoid receptors affect alcohol dependence

  This study is looking at how blocking certain receptors in the brain might help people who struggle with alcohol dependence by reducing their cravings and drinking, and it’s aimed at finding better ways to treat alcohol use disorders.

  NIH research Scripps Research Institute, the · La Jolla, United States · NIH-10931639

• Targeting opioid systems to treat alcohol dependence

  This study is looking at how alcohol dependence affects the brain's opioid system and is testing a new drug called CERC-501 to see if it can help people who are trying to overcome alcohol use disorder.

  NIH research Karolinska Institute · Solna, Sweden · NIH-10915690

• How oxytocin affects brain signals related to alcohol dependence

  This study is looking at how a hormone called oxytocin might help reduce stress and cravings for alcohol by affecting certain brain areas, which could lead to new ways to support people dealing with alcohol dependence.

  NIH research University of Tennessee Health Sci Ctr · Memphis, United States · NIH-10909436

• Finding new ways to treat alcohol dependence and prevent relapse

  This study is looking at how drinking too much alcohol affects the brain and why some people might start drinking again after getting help, with the goal of finding better treatments for anyone dealing with alcohol use disorder.

  NIH research Wake Forest University Health Sciences · Winston-Salem, United States · NIH-10840255

• The role of oxytocin in alcohol dependence and stress response

  This study is looking at how a hormone called oxytocin, which helps reduce stress, affects certain parts of the brain related to stress and alcohol addiction, to find new ways to help people struggling with alcohol use.

  NIH research University of Tennessee Health Sci Ctr · Memphis, United States · NIH-10681420

• How oxytocin and stress hormones affect alcohol dependence

  This study is looking at how two brain chemicals, oxytocin and CRF, affect drinking habits in people who struggle with alcohol dependence, to find out how oxytocin might help reduce stress-related drinking and lead to better treatments for those dealing with this issue.

  NIH research University of Tennessee Health Sci Ctr · Memphis, United States · NIH-10655413

• Investigating how vasopressin affects pain and alcohol dependence

  This study looks at how feelings of pain and negative emotions can affect drinking habits in people with alcohol use disorder, using animal models to see how a specific brain chemical might play a role, with the hope of finding better treatments for those dealing with both chronic pain and alcohol issues.

  NIH research Lsu Health Sciences Center · New Orleans, United States · NIH-10441221

Related topics

Quick answers

How many Alcohol Dependence clinical trials are recruiting right now?

12, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 10 countries. The most sites are in United States (4 trials), Germany (2 trials), Hong Kong (1 trial), Australia (1 trial), France (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2: 2, Phase 1: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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