Peer support for liver transplant recipients with a history of alcohol use disorder
Official title: Peer Support to Enhance Care for Liver Transplant Recipients Who Had Alcohol-Associated Liver Disease
Run by Johns Hopkins University · NCT07397598 · Data updated 2026-11-12
This study tests whether having a peer support specialist helps liver transplant recipients with prior alcohol use disorder stay abstinent and stay engaged in care.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 95 (estimated) |
| Sponsor | Johns Hopkins University Academic / other |
| Locations | 1 site (Baltimore, Maryland) |
| Status | Recruiting |
| Started | October 27, 2026 |
| Main results expected | June 2029 |
| Study ends | June 2029 |
| Registry record updated | October 28, 2026 |
| Trial ID | NCT07397598 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
English-speaking adults who had a liver transplant for alcohol-associated liver disease and have 1–3 years of continuous abstinence at trial entry.
✕Probably not a fit
Individuals without a history of alcohol-associated liver disease or those not abstinent for 1–3 years at entry may see little or no benefit.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This single-arm study adds peer support specialists to routine post-transplant care for liver transplant recipients with alcohol-related liver disease, starting in years 2–4 after transplant. PSSs provide structured, confidential conversations, active listening, and brief counseling to support adherence to medical care and reduce relapse risk. Outcomes will include self-reported and biomarker-based alcohol use, continuation in follow-up with transplant teams, and overall survival, compared to a historical control group. The trial aims to see if peer support improves long-term recovery and health maintenance after liver transplantation for ALD.
Why it matters
Potential benefit: If successful, patients may maintain abstinence longer and stay engaged with medical care, potentially improving survival.
How similar studies have gone: Past studies in other chronic conditions suggest peer support can improve adherence and outcomes, but this specific approach in ALD/LT patients is novel.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * English speakers * Received a liver transplant for alcohol-associated liver disease * Has 1 to 3 years of continuous alcohol abstinence at the time of trial entry Exclusion Criteria: * Liver transplant recipients without a history of alcohol-associated liver disease * Inability to provide informed consent * Active participation in a separate intervention trial for alcohol use disorder
Where it's running
-
Johns Hopkins University School of Medicine
Baltimore, Maryland, United States Recruiting
Study contacts
- Principal investigator: Po-Hung Chen, MD, PhD — Johns Hopkins University
- Study coordinator: Po-Hung Chen, MD, PhD
- Email: pchen37@jhmi.edu
- Phone: 410-550-1793
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.