Sponsor or institution
Clinical trials and research at University of Iowa
As of November 12, 2026, Find a Trial lists 103 clinical trials run by University of Iowa that are recruiting, at sites in 8 countries (most in United States (102), Canada (3), Australia (2)). 2 were first registered in the last 30 days. By phase: Early Phase 1 (11), Phase 1 (9), Phase 2 (8), Phase 4 (7). There are also 725 NIH-funded research projects at this institution, with $383.4 million in listed awards. Every study is explained in plain English. Data from ClinicalTrials.gov and NIH RePORTER, updated November 12, 2026.
- 103Clinical trials
- 725NIH research projects
- 2New in 30 days
- 8Countries
Newest trials
All recruiting trials (103)
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VT-101 in Advanced Ovarian Cancer: early safety study in adults
This early-phase trial tests VT-101 in adult women with advanced, recurrent, or relapsed epithelial ovarian cancer to see if it is safe, how the body handles it, and whether there are any initial signs of activity.
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Comparing Training Methods to Reduce Forefoot Loading with a Carbon Fiber Dynamic Orthosis
This study tests whether different training methods (no feedback, visual feedback of forefoot force, or visual feedback of cuff forces) help healthy adults use a carbon fiber dynamic ankle-foot orthosis more effectively during walking.
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Detoxify for IVF: Cutting Everyday Pollutants to Help Infertility
This study tests a guide to help IVF patients reduce everyday environmental pollutants and sees if it lowers chemical exposure in urine, blood, and follicular fluid.
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Biomarkers to see if rotator cuff repairs will heal after surgery
This study tests whether biomarkers in shoulder tissue and synovial fluid can predict whether a rotator cuff repair will heal, using MRI after surgery to compare those who heal with those who don’t.
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Personalized supervised exercise program for adults with breast or gynecologic cancer
A small pilot study will test a supervised, personalized exercise program to see if it is safe, feasible, and acceptable for adults with a history of breast or gynecologic cancer.
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Obesity and normal-weight healing after gum graft surgery using collagen plug or PRF
This study tests whether healing after a gum graft differs by weight class (obese vs. normal weight) and compares platelet-rich fibrin clot to the standard collagen plug.
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Perinatal Autism Genetics and Epigenetics study
We’re testing whether prenatal stress and early social experiences can cause epigenetic changes linked to autism in children, by following pregnant women and their kids using a smartphone tool.
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Antidepressant Therapy for Blood Vessel Health After Preeclampsia
This study tests whether an antidepressant can improve blood vessel health in women who had preeclampsia and may have depression.
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Sitagliptin Plus Pembrolizumab in Advanced Renal Cell Carcinoma and Melanoma
This study tests whether adding sitagliptin to pembrolizumab is safe and might help people whose advanced kidney cancer or melanoma stopped responding to prior PD-1/PD-L1 therapy.
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Sirolimus pre-conditioning before a T-cell engaging antibody in multiple myeloma
This study tests whether giving sirolimus before a T-cell engaging antibody can be safe and improve responses in adults with relapsed or refractory multiple myeloma who have had prior T-cell engager therapy.
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Lung cancer screening program using a blood test and pharmacist referrals
This program tests a blood test plus a pharmacist-led referral to see if screening for lung cancer can be made easier for eligible adults in Iowa.
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Sitagliptin plus bevacizumab for recurrent grade 4 glioma
This study tests whether adding sitagliptin to bevacizumab can help people whose recurrent glioblastoma or other grade 4 gliomas respond to treatment and to find a safe dose when used with bevacizumab.
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Quality of life for people with glaucoma
This project asks adults with glaucoma to complete vision-related questionnaires before and 3–6 months after starting treatment or having surgery to see if their scores change.
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T2* MRI and blood tests to predict progression of malignant gliomas
This trial tests whether T2* MRI scans and blood biomarkers can help predict how WHO grade IV malignant gliomas will change or come back in adults.
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5-Azacitidine with PD-1/PD-L1 Inhibitor in PD-1/PD-L1 Refractory Tumors
This phase I study tests different doses of 5-azacitidine combined with a PD-1/PD-L1 blocker to see if the combo can help patients whose tumors no longer respond to PD-1/PD-L1 therapy.
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Intravesical gemcitabine followed by docetaxel for high-grade BCG-unresponsive NMIBC
This trial tests whether putting gemcitabine then docetaxel directly into the bladder can treat adults with high-grade non-muscle-invasive bladder cancer that did not respond to BCG.
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Post-filter hematocrit calculation for adults on continuous renal replacement therapy
This will test whether a calculation can accurately predict post-filter hematocrit compared with machine-measured values in adults receiving continuous renal replacement therapy.
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Mitochondrial oxidative stress and blood vessel health in young adults with early life adversity
We will test whether taking the mitochondrial antioxidant MitoQ can improve blood vessel function in healthy 18–29-year-olds who experienced significant adverse events in childhood.
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Terazosin and ATP in ALS: see if this drug helps energy in ALS patients
This pilot study tests whether terazosin, taken daily, can raise ATP levels and be safe for adults with ALS.
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How the mediodorsal thalamus supports flexible thinking and decision making
This study will test whether the mediodorsal thalamus helps flexible thinking in healthy adults, with implications for people with schizophrenia or ADHD.
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Ankle-foot braces versus surgery to improve walking and balance in CMT
This will test whether ankle-foot braces or surgical correction better improve walking, balance, and mobility for people aged 12 to 75 with genetically confirmed Charcot–Marie–Tooth disease.
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Giving ketorolac for pain after egg retrieval in fresh embryo transfer IVF cycles
This trial tests whether a single IV dose of ketorolac given after egg retrieval helps control pain for people planning a day-5 fresh embryo transfer without lowering their chances of pregnancy.
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Creating Health online course for people with rheumatological conditions
This project will test whether an online course about diet and self-care helps adults with rheumatoid arthritis, Sjogren's syndrome, lupus, mixed connective tissue disease, or psoriatic arthritis reduce fatigue and improve quality of life.
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High-dose intravenous vitamin C combined with azacitidine and venetoclax for acute myeloid leukemia
This trial tests whether adding high-dose IV vitamin C to azacitidine and venetoclax helps people with newly diagnosed AML who are not candidates for intensive chemotherapy.
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Intermittent hypoxia to improve brain blood flow in older adults with type 2 diabetes
This trial will test whether brief, repeated bouts of lower oxygen (intermittent hypoxia) can improve brain blood flow and cognition in adults aged 60–85 with type 2 diabetes, compared with non-diabetic older adults and a sham (normoxia) control.
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Pregnancy 24/7 Offspring: tracking infant growth and heart-risk after pregnancy
This project will test whether a pregnant person's daily activity, sitting time, and sleep across pregnancy are linked to their child's growth, body fat, and early heart-disease risk up to age 2.
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Home-based pulmonary rehabilitation for children after tuberculosis
This study will test a 6-week home pulmonary rehabilitation program to see if children aged 6–17 who finished treatment for pulmonary TB can follow the program and improve walking distance and quality of life.
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Diltiazem versus adenosine for treating supraventricular tachycardia in the emergency room
This study will see if IV diltiazem or IV adenosine works better and causes fewer side effects for adults who come to the emergency department with supraventricular tachycardia.
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E-tailored pain management support for family caregivers of people with dementia using the PACE-app
This trial tests whether the PACE-app, a web-based tool, can help family caregivers of people with dementia better manage their loved ones' chronic pain and improve caregiver confidence, communication, and well-being compared with usual care.
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Endovascular clot-removal guided by automated standard CT for late-window ischemic stroke
This trial will test whether removing clots with endovascular therapy guided only by automated non-contrast CT can help adults with large-vessel ischemic stroke treated 6–72 hours after symptoms begin.
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Adenosine versus diltiazem for stopping SVT in the emergency department
This pilot will try two IV medicines—adenosine and diltiazem—in adults with acute, stable SVT in the Emergency Department to learn which treatment patients prefer and how they feel afterward.
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Evaluating genetic factors in patients with calcium phosphate kidney stones
This study is testing if certain genetic factors in people with calcium phosphate kidney stones can help us understand how to prevent and manage these stones better.
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Robotic versus manual cochlear implant electrode insertion to reduce inner-ear trauma.
This test tries a robotic insertion tool versus the usual manual technique to see if it reduces inner-ear damage and preserves residual hearing in people getting cochlear implants.
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Home blood pressure monitoring with pharmacist support for older adults with multiple chronic conditions
This study will test whether home blood pressure monitoring combined with clinical pharmacist support lowers systolic blood pressure in people 65 and older who have multiple chronic conditions and uncontrolled hypertension.
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Xenon MRI–guided radiation for lung cancer
This project will try using hyperpolarized xenon MRI to map which parts of the lungs are working and guide stereotactic body radiation therapy to spare healthy lung in people with lung cancer.
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How gestational diabetes affects brain blood flow after pregnancy
This study will test whether a past diagnosis of gestational diabetes changes brain blood flow and blood-vessel function in women within five years after giving birth.
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Examining language outcomes in adults with and without Developmental Language Disorder
This study looks at how language skills change over time in adults with Developmental Language Disorder compared to those who developed language normally.
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Understanding how cochlear implant users hear speech in noise
This study is trying to see how cochlear implant users hear speech in noisy places by looking at their brain activity compared to people with normal hearing.
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Do adults who carry one cystic fibrosis gene have higher risk of heat-related dehydration and electrolyte problems?
This study will try to see if adults who carry one cystic fibrosis gene are more likely to get dehydrated or have electrolyte problems during heat exposure than similar adults without the gene.
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Evaluating postoperative activity restrictions after midurethral sling placement
This study is testing whether patients who have had a midurethral sling procedure for stress urinary incontinence do better with strict activity limits or no limits after surgery.
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Hand-soaking test to predict cystic fibrosis carrier status.
Try a hand-soaking test to see if it can identify people who carry the cystic fibrosis gene.
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Direct transfer to the angiography suite versus emergency department evaluation for suspected large vessel occlusion stroke
This trial will see if taking adults with suspected large vessel occlusion stroke directly to the angiography suite instead of first evaluating them in the emergency department helps people recover better when they arrive within 7 hours of symptom onset.
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Effects of high-salt intake on women after preeclampsia
This study is testing how eating a lot of salt affects blood vessel health in women who had preeclampsia during pregnancy, to see if a medication can help improve their condition.
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Progressive Achilles-loading program with remote clinician support
This trial tests whether a single telehealth visit plus self-guided exercise and education works as well as multiple telehealth physical therapy visits for adults with Achilles tendon pain.
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Custom carbon-fiber dynamic orthosis to reduce forefoot loading
This study will test whether a custom carbon-fiber dynamic orthosis, with or without visual feedback training, can reduce forefoot loading in adults with below‑knee injuries who need a CDO.
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Using angiotensin II to treat septic shock in the emergency department
This study is testing if giving angiotensin II can help people in septic shock maintain their blood pressure better in the emergency department.
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Examining brain mechanisms of TMS in depression and anxiety
This study is testing how a brain treatment called TMS affects people with depression and anxiety by looking at their brain activity during and after the treatment.
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Evaluating PSMA in Metastatic Triple Negative Breast Cancer
This study is testing if a special imaging technique can help find cancer spots in patients with metastatic triple negative breast cancer to see if new treatments targeting those spots could work.
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Home monitoring for Parkinson's disease using speech and activity tracking
This study is testing if tracking speech and activity at home with wearable devices can help understand changes in people who are newly referred for Parkinson's evaluation or recently diagnosed with the disease.
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Effect of different root canal procedures on bacteria in infected teeth
This study is testing three different root canal treatments to see which one is best at reducing bacteria in infected teeth.
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Comparing two methods of pain relief after abdominal surgery
This study is testing two different ways to give pain relief after abdominal surgery to see which one helps patients feel better and recover faster.
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Investigating the role of endothelin-1 in blood vessel function after gestational diabetes
This study is testing how a substance called endothelin-1 affects blood vessel function in women who had gestational diabetes to see if insulin can help improve their heart health after pregnancy.
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Personalized brain stimulation to improve hand function after stroke
This study is testing a personalized brain stimulation technique to see if it can help people recover better hand function after having a stroke.
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Comparing experiences of over-the-counter and audiologist-fitted hearing aids
This study looks at how people with mild-to-moderate hearing loss feel about using over-the-counter hearing aids compared to those fitted by an audiologist to see which option works better for their hearing and quality of life.
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Investigating how inflammation affects blood vessel health in e-cigarette users
This study is testing how inflammation affects blood vessel health in young adults who use e-cigarettes compared to those who don’t, while also seeing if an anti-inflammatory medication can help improve their vascular function.
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Understanding how age-related voice changes affect social interactions
This study is testing how changes in the voice due to aging affect social interactions and feelings of loneliness in older adults, while also looking at whether voice therapy can improve their quality of life.
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Speech intervention for bilingual children with speech sound disorders
This study is testing different speech treatments in English and Spanish to see which helps bilingual children with speech sound disorders improve their speaking skills better.
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MRI techniques for assessing lung transplant health
This study is testing new MRI techniques to see if they can help doctors better understand lung health in people who have had a lung transplant.
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Psilocybin versus ketamine for reducing heavy drinking in alcohol use disorder
This trial will test whether a single 30 mg dose of psilocybin or a weight-based 0.75 mg/kg dose of ketamine, each given with individual psychotherapy, can reduce heavy drinking in adults with moderate to severe alcohol use disorder.
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Customized Lutetium-177 treatment for neuroendocrine tumors
This study is testing if a personalized dose of Lutetium-177 can improve treatment results for adults with hard-to-treat neuroendocrine tumors compared to standard treatment.
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Evaluating custom dynamic orthoses for foot injuries
This study is testing how different styles of custom foot braces can help adults with long-term injuries recover better and move more easily.
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Cognitive training to help middle-aged adults stick to exercise
This study tests if a new brain training program can help middle-aged adults stick to their exercise routines better.
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Paced heart rate acceleration for improving heart function
This study is testing if a special heart pacing treatment that mimics exercise can help people with systolic heart failure feel better and improve their heart function compared to a fake treatment.
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Therapy to help patients before heart surgery
This study tests whether Acceptance and Commitment Therapy can help patients feel less anxious and depressed before heart surgery to improve their overall well-being.
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Examining how e-cigarette use affects blood vessels differently in men and women
This study is testing how using e-cigarettes affects blood vessels in young men and women to see if there are any differences in their responses.
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Effects of heel distraction height on foot loading with carbon fiber orthoses
This study tests how different heel heights in special foot supports can change the way people with lower limb injuries walk and feel during movement.
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Assessing force measurement in carbon fiber orthoses
This study is testing how well special sensors can measure force in carbon fiber ankle-foot braces to see how they work for healthy people and those with nerve issues.
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Using palbociclib and pembrolizumab for treating undifferentiated pleomorphic sarcoma
This study is testing if a combination of two drugs, palbociclib and pembrolizumab, can help improve treatment for people with undifferentiated pleomorphic sarcoma by looking at changes in their tumors after a few weeks.
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Essential amino acid supplementation for patients with femoral fractures
This study is testing if taking essential amino acids for four weeks after surgery can help people with femoral fractures recover better and keep their muscle strength.
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Investigating oxidative stress and blood vessel function in women with a history of gestational diabetes
This study is trying to see how oxidative stress affects blood vessel function in women who had gestational diabetes in the past five years.
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Using metformin to improve blood vessel function in women after gestational diabetes
This study is testing if metformin can help improve blood vessel health in women who had gestational diabetes to reduce their risk of heart problems later on.
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Comparing two methods for pain control after shoulder surgery
This study is testing whether a new way of delivering pain relief after shoulder surgery works better than the standard method to help patients feel less pain and recover more comfortably.
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Using preoperative laxatives to improve recovery after robotic urologic surgery
This study is testing if taking a laxative before robotic surgery for prostate or kidney cancer can help patients recover better and feel less discomfort afterward.
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Effects of Prenatal Aspirin on Postpartum Vascular Health
This study tests if taking low-dose aspirin during pregnancy helps improve blood vessel health after giving birth in women who had preeclampsia compared to those with normal pregnancies.
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Assessing respiratory infection risks in CF carriers
This study is testing if being a carrier of the CFTR gene mutation increases the risk of respiratory infections by comparing CF carriers with non-carriers.
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Investigating the impact of being a CF carrier on kidney and pancreatic health
This study is trying to see if people who carry the cystic fibrosis gene are at a higher risk for kidney and pancreatic diseases compared to others.
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Using nerve blocks to reduce pain and improve recovery in older adults after spinal surgery
This study is testing if a special nerve block can help older adults feel less pain and recover better after spinal surgery.
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Exploring blood clotting mechanisms in COVID-19 patients
This study is trying to understand how blood clotting works in hospitalized COVID-19 patients by looking at their blood samples over time.
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An app to help mothers understand premature infant resuscitation
This study is testing a new app that helps mothers understand what happens during resuscitation for premature infants before delivery.
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Neoadjuvant treatment with dostarlimab for advanced colon cancer
This study is testing if the immunotherapy drug dostarlimab can shrink tumors in patients with advanced colon cancer so they might not need surgery.
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Collecting blood samples from patients undergoing plasma exchange
This study is collecting blood samples from patients with immune-related diseases who are having plasma exchange to see how their antibody levels change during treatment and to use the samples for future research.
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Comparing rehabilitation methods after knee surgery using a smart brace and physical therapy
This study is testing whether using a smart knee brace after knee surgery can help people recover just as well as traditional physical therapy.
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Effects of AFO heel height and stiffness on walking
This study tests how different heel heights and stiffness of ankle foot orthoses affect the walking of people who use them every day.
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Low-dose oral doxycycline targeting MMP-9 for persistent wet AMD
This trial tests whether taking low-dose doxycycline daily can help people with wet AMD who still have sub-retinal fluid despite regular anti-VEGF eye injections.
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Registry for patients with treatment-resistant depression and OCD receiving interventional therapies
This study is testing different treatments like ECT, TMS, and ketamine to see how they help people with treatment-resistant depression and OCD feel better.
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Understanding the causes of Sudden Unexpected Death in Epilepsy
This study is trying to understand why some people with epilepsy suddenly die by looking at how seizures affect their breathing and heart function over ten years.
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Home monitoring of bladder pressure with a new device
This study is testing a new device that helps people with neurogenic bladder monitor their bladder pressure at home while using catheters to see if it works better than regular doctor visits.
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Evaluating activity levels in patients receiving bone marrow transplants
This study looks at how active people are before and after bone marrow transplants to see if it affects their recovery, hospital stay, and overall well-being.
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Investigating sleep apnea in patients with certain blood disorders
This study is trying to see if sleep apnea affects the progression of blood disorders like MGUS and multiple myeloma in patients.
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Effects of melatonin on brain health and cognition in older adults
This study is testing if taking 5mg of melatonin can improve brain health and thinking skills in older adults, especially those with mild cognitive impairment, over nine months.
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Imaging techniques for diabetic foot ulcers
This study is testing different ways to take pictures and measure diabetic foot ulcers to see which method works best for capturing their size.
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Investigating cell-free DNA in cardiac sarcoidosis
This study is testing if cell-free DNA can help doctors detect active heart inflammation in people with sarcoidosis.
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New methods to diagnose and monitor light sensitivity
This study is testing new ways to diagnose and track light sensitivity and headaches in people with conditions like traumatic brain injury and migraines using advanced technology.
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Using a special device to improve outcomes for stroke patients during helicopter transport
This study is testing whether a special device that uses blood pressure cuffs can help protect the brains of stroke patients during their helicopter transport to a hospital.
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New technology for assessing eye structure and function
This study is testing a new eye imaging technology to see if it can better understand the health of the retina in people with different eye diseases compared to regular vision tests.
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Effects of stimulant medication on disruptive behavior in children with ADHD
This study tests how stimulant medication affects disruptive behavior, preferences, and impulse control in children and teens with ADHD.
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Reducing oxytocin during labor to improve fetal heart rate outcomes
This study tests if lowering the amount of oxytocin given during labor can help improve fetal heart rate patterns in healthy women having their first baby.
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Cerebellar stimulation to improve cognitive function and mood
This study is testing if a special brain stimulation can help improve thinking and mood in people with schizophrenia, autism, bipolar disorder, and Parkinson's disease.
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Observing the effectiveness of pacing therapy for congenital heart disease patients with atrial arrhythmias
This study is testing how well pacing therapy works for people with congenital heart disease who have heart rhythm problems and already have devices to help manage them.
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Using ketamine to treat major depression in patients with a family history of alcohol use disorder
This study is testing if a single dose of ketamine can help people with treatment-resistant depression who have a family history of alcohol problems feel better.
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Understanding genetics of Charcot-Marie-Tooth disease
This study is trying to find new genes that cause Charcot-Marie-Tooth disease and see how they affect symptoms in people with CMT type 1A.
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Evaluating the natural history of Charcot Marie Tooth Disease
This study is trying to learn more about how different types of Charcot Marie Tooth Disease affect people over time and how their genetics play a role.
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Understanding early signs of dystroglycanopathies in muscular dystrophy
This study is looking to find out the early signs and symptoms of dystroglycanopathies in people with muscular dystrophy to help improve future treatments and care.
NIH-funded research (newest 40 of 725)
Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.
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Healthier Workplace Center for the Midwest
A multi-site NIH grant aims to improve the health and well-being of workers by coordinating research and sharing evidence-based strategies.
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Serotonin pathways and how they help recovery after seizures
A researcher is studying how serotonin-related brain circuits influence waking up after seizures, using mouse models to understand why some people with epilepsy have dangerous breathing pauses after seizures.
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Serotonin brain circuit clues to safer sleep after seizures
Aims to understand how brain serotonin systems and CO2-triggered arousal affect recovery after seizures in mouse models to reduce SUDEP risk.
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Improved ICU Mobility Care through a Smart Guideline in the EHR
A hospital study will test a smart tool in the electronic health record to help ICU teams identify when to start patient-friendly mobility activities and coordinate a plan tailored to each patient.
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Ultrasound biomarkers to diagnose and predict treatment response for plantar heel pain
A study will test advanced ultrasound imaging to find biomarkers that help diagnose plantar heel pain and predict who will respond to targeted treatments.
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Pain and aging: how nerve cells become more sensitive with age
This project looks at why older adults often have chronic pain by studying how nerve cells in aging animals become more sensitive and how inflammation might drive this change.
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Infection prevention and antibiotic stewardship: closing gaps at Iowa
This grant supports a patient-focused program to improve infection prevention and prudent antibiotic use at the University of Iowa.
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From Genes to Community: Understanding Birth Clefts and Supporting Families
A multi-omics study from bench to community to find genetic risk factors for cleft lip/palate and use those findings to support families and caregivers in Africa.
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How cells fix DNA to prevent brain diseases
This NIH grant supports research to understand how cells carefully repair DNA to protect against brain disorders and aging.
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How heart injury changes immune cells and their roles
Researchers are studying how immune cells called monocytes turn into different types of heart macrophages after a heart attack to understand how to prevent damaging heart remodeling.
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Hawkeye IDDRC: Advancing understanding and care for intellectual and developmental disabilities
A multi-center program aims to combine basic and clinical work to improve prevention, diagnosis, and treatment of intellectual and developmental disabilities across ages, with a focus on underserved rural populations.
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Serotonin’s role in mental effort under ongoing stress and cognitive control
A study to understand how serotonin influences brain and thinking processes when people stay motivated to work under ongoing stress.
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Advancing Immunization Services through a Coordinating Center
A national program in Iowa aims to boost vaccination rates, especially in rural areas, by tailoring vaccine information to people’s motivations and uncertainty so they’re more confident about immunizations.
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Rural Cancer Prevention and Control Network Center
A rural-focused program to spread proven cancer prevention, screening, treatment, and survivorship practices in Iowa through collaborative networks.
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AKI-related delirium after heart surgery
This grant funds research to understand why some people develop delirium after heart surgery when they also have acute kidney injury.
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Deep Mutational Scanning of HIV-1 Capsid to Understand Fitness and Lenacapavir Resistance
A new approach will map how every possible change in the HIV-1 capsid protein affects the virus’s fitness and resistance to the drug lenacapavir.
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How m6A RNA Modifications Affect HIV-1 Replication in CD4+ T Cells
This grant studies how a common RNA modification (m6A) influences HIV-1 replication in human CD4+ T cells, with the aim of uncovering new ways to understand and potentially better manage HIV infection.
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Vascular AI for guided care in fetal growth restriction
A new AI-powered approach uses fetal blood flow data to help doctors decide the best time to deliver babies at risk for fetal growth restriction.
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Genetic and epigenetic clues in orofacial clefts
Researchers are studying how DNA methylation and genetic factors interact to influence the risk of nonsyndromic orofacial clefts in people and families.
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Redox-based approach to boost DIPG treatment in children
A pediatric brain tumor research grant explores using redox-focused drugs to help make DIPG tumors more responsive to standard therapy.
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Mutation-independent gene therapy for CEP290-linked retinal degeneration
A patient-facing study exploring new AAV-based gene therapy approaches to help children with CEP290-related vision loss.
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Childhood-to-Adult Brain Changes in Huntington’s Disease with Gene Expansion
A study follows children and young adults who carry or do not carry the Huntington’s disease gene expansion to understand how their brains and thinking change over time.
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Role of IRS2 in heart calcium balance and arrhythmia risk
Aims to find out how IRS2 helps keep heart calcium steady and prevent dangerous rhythms after a heart attack.
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Understanding how melanoma cells change state to spread and resist therapy
This project studies how melanoma cells switch between different states that affect how fast they grow and spread, with the goal of finding ways to stop metastatic progression.
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Neural systems that control choosing cocaine vs. safety in rats
This grant studies how the brain decides between seeking cocaine and avoiding it, using rat tests to understand the choices people with cocaine use disorder might face.
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Personalized brain‑state magnetic stimulation to improve hand recovery after stroke
This project tests whether timing brief magnetic brain stimulation to each stroke survivor's brain activity can help them regain better use of their affected hand.
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Genetic requirements for making lipoteichoic acid in C. difficile
A patient-relevant project aims to understand how a key bacterial component is built in the gut bug Clostridioides difficile to guide the development of better, more precise treatments.
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Non-opioid target to reverse opioid-related brain changes
Aims to see if a non-opioid drug target can reverse brain changes that fuel opioid craving and help people stay abstinent.
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FABP5: How fats in obesity may drive triple negative breast cancer
A study exploring how a fat‑binding protein called FABP5 helps obesity-related fats push the spread of aggressive breast cancer in models that resemble human disease.
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Network support to improve rural cancer care quality and access
A network-based approach helps rural hospitals deliver high-quality, guideline-concordant cancer care to breast cancer patients in rural areas.
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Immune cell traffic in the cochlea after cochlear implantation
A short project will study how immune cells move through the cochlea’s blood vessels and lymphatics after cochlear implantation to understand inflammation and hearing outcomes.
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Marburg virus and skin: how the virus interacts with the body’s largest organ
This project looks at how Marburg virus may infect skin and spread in the body, aiming to reveal how skin involvement could affect illness.
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Broad-spectrum mold-fighting medicines discovered by high-throughput screening
This grant aims to find new antifungal compounds that work against hard-to-treat molds like Aspergillus and Mucor, using a fast screening method to identify promising candidates.
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Targeting brain support cells to fight obesity-related high blood pressure
A study from the University of Iowa is looking at how brain cells called astrocytes may influence obesity-related hypertension and whether targeting them could help lower blood pressure.
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Organoid models to study how fibroblasts talk to epithelial cells and the surrounding matrix
A study using 3D organoid systems to understand how fibroblasts communicate with nearby epithelial cells and remodel the surrounding matrix, with relevance to cancer and fibrosis.
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Understanding how nursing homes can sustain quality improvements
This grant studies why some nursing homes keep improving after a special oversight program and how those improvements affect residents, staff, and finances.
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OASIS: a personalized cancer symptom app to help you manage treatment burden
A mobile app helps adults undergoing cancer treatment track symptoms, get tailored tips, and connect with support to feel better and stay on track with their care.
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Lipid droplet proteins and actin remodeling in egg development
Aims to understand how lipid droplets influence the actin skeleton to produce healthy eggs in fruit flies, with findings that could inform human fertility.
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Food safety surveillance and lab readiness in Iowa to protect consumers
A multi-year effort to strengthen how state labs sample, test, and report food safety data to support FDA goals and protect people who eat food.
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Mitochondria-Targeted Regeneration of Jaw Bone in Periodontitis
A study to help adults with periodontitis rebuild jaw bone using a novel mitochondria-smart therapy.
Quick answers
How many clinical trials run by University of Iowa are recruiting right now?
103, as of November 12, 2026. 2 of them were first registered in the last 30 days. We update this list each time we refresh our data from ClinicalTrials.gov.
Where are these trials running?
In 8 countries. The most sites are in United States (102 trials), Canada (3 trials), Australia (2 trials), Cyprus (2 trials), Italy (2 trials). Each study page lists its sites and which ones are recruiting.
What phases are they in?
Early Phase 1: 11, Phase 1: 9, Phase 2: 8, Phase 4: 7. Trials with no phase listed are usually device, behavioural or observational studies.
How do I join one?
Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.
Find the studies that fit you
A list is a starting point. Tell us your situation in your own words and we'll rank the studies that match and explain why. It's free and needs no account.