Investigating sleep apnea in patients with certain blood disorders
Sleep Apnea in Patients With MGUS and MM
This study is trying to see if sleep apnea affects the progression of blood disorders like MGUS and multiple myeloma in patients.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 200 (estimated) |
| Ages | 18 Years to 99 Years |
| Sex | All |
| Sponsor | University of Iowa Academic / other |
| Locations | 1 site (Iowa City, Iowa) |
| Trial ID | NCT04114084 on ClinicalTrials.gov |
What this trial studies
This observational study focuses on patients diagnosed with monoclonal gammopathy of undetermined significance (MGUS) or multiple myeloma (MM) to explore the relationship between these conditions and sleep apnea. Participants will provide bone marrow specimens during routine procedures, minimizing discomfort and risk. The study aims to understand how chronic intermittent hypoxia from sleep apnea may influence the progression of MM, particularly through mechanisms related to angiogenesis and cell development. Preliminary findings suggest that sleep apnea could play a role in the disease's advancement, warranting further investigation.
Who should consider this trial
Good fit: Ideal candidates include patients diagnosed with MGUS or MM who are scheduled to undergo a bone marrow biopsy as part of their standard care.
Not a fit: Patients without a diagnosis of MGUS or MM, or those not undergoing a bone marrow biopsy, are unlikely to benefit from this study.
Why it matters
Potential benefit: If successful, this study could enhance understanding of how sleep apnea affects the progression of multiple myeloma, potentially leading to improved patient management strategies.
How similar studies have performed: While the specific approach of this study is novel, preliminary findings in related research suggest potential pathways that warrant further exploration.
Eligibility criteria
Show full inclusion / exclusion criteria
Patients diagnosed with MGUS or MM who will be receiving a bone marrow biopsy as part of their standard of care are eligible to participate in this study
Where this trial is running
Iowa City, Iowa
- University of Iowa — Iowa City, Iowa, United States (Recruiting)
Study contacts
- Principal investigator: Michael Tomasson, MD — University of Iowa
- Study coordinator: Michael Tomasson, MD
- Email: michael-tomasson@uiowa.edu
- Phone: 319-356-4200
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.