Investigating sleep apnea in patients with certain blood disorders
Official title: Sleep Apnea in Patients With MGUS and MM
Run by University of Iowa · NCT04114084 · Data updated 2026-11-12
This study is trying to see if sleep apnea affects the progression of blood disorders like MGUS and multiple myeloma in patients.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years to 99 Years |
| Sex | All |
| Enrollment | 200 (estimated) |
| Sponsor | University of Iowa Academic / other |
| Locations | 1 site (Iowa City, Iowa) |
| Status | Recruiting |
| Started | May 23, 2019 |
| Main results expected | May 23, 2030 |
| Study ends | May 23, 2030 |
| Registry record updated | November 10, 2025 |
| Trial ID | NCT04114084 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates include patients diagnosed with MGUS or MM who are scheduled to undergo a bone marrow biopsy as part of their standard care.
✕Probably not a fit
Patients without a diagnosis of MGUS or MM, or those not undergoing a bone marrow biopsy, are unlikely to benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational study focuses on patients diagnosed with monoclonal gammopathy of undetermined significance (MGUS) or multiple myeloma (MM) to explore the relationship between these conditions and sleep apnea. Participants will provide bone marrow specimens during routine procedures, minimizing discomfort and risk. The study aims to understand how chronic intermittent hypoxia from sleep apnea may influence the progression of MM, particularly through mechanisms related to angiogenesis and cell development. Preliminary findings suggest that sleep apnea could play a role in the disease's advancement, warranting further investigation.
Why it matters
Potential benefit: If successful, this study could enhance understanding of how sleep apnea affects the progression of multiple myeloma, potentially leading to improved patient management strategies.
How similar studies have gone: While the specific approach of this study is novel, preliminary findings in related research suggest potential pathways that warrant further exploration.
Who can join: the full rules
Show full inclusion / exclusion criteria
Patients diagnosed with MGUS or MM who will be receiving a bone marrow biopsy as part of their standard of care are eligible to participate in this study
Where it's running
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University of Iowa
Iowa City, Iowa, United States Recruiting
Study contacts
- Principal investigator: Michael Tomasson, MD — University of Iowa
- Study coordinator: Michael Tomasson, MD
- Email: michael-tomasson@uiowa.edu
- Phone: 319-356-4200
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
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Prolonged overnight fasting combined with a Mediterranean-style diet for people with multiple myeloma or precursor conditions
This program will test whether longer overnight fasting paired with a Mediterranean-style eating plan is doable for adults with MGUS, smoldering myeloma, or newly diagnosed multiple myeloma who are starting treatment.
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This study is testing whether a plant-based diet and certain supplements can change butyrate levels in the stool of people with smoldering multiple myeloma.
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Screening for M-protein in relatives of multiple myeloma patients in China
This study is trying to see if screening for a specific protein in the blood can help find early signs of a blood condition in family members of people with multiple myeloma in China.
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Understanding different types of multiple myeloma precursor conditions
This study is trying to tell the difference between two early stages of multiple myeloma, smoldering multiple myeloma and monoclonal gammopathy of undetermined significance, to better understand how they progress or stay stable.
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Registry and sample resource for patients with plasma cell disorders
This study is gathering information from patients with plasma cell disorders like multiple myeloma to see how to improve their treatment and quality of life.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.