Collecting blood samples from patients undergoing plasma exchange
Assessment of Changes in Normal and Pathological Immune Factors in Patients Undergoing Plasma Exchange
University of Iowa · NCT05004493
This study is collecting blood samples from patients with immune-related diseases who are having plasma exchange to see how their antibody levels change during treatment and to use the samples for future research.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 200 (estimated) |
| Ages | 12 Years to 99 Years |
| Sex | All |
| Sponsor | University of Iowa (other) |
| Locations | 1 site (Iowa City, Iowa) |
| Trial ID | NCT05004493 on ClinicalTrials.gov |
What this trial studies
This observational study focuses on patients with immune-mediated diseases who undergo plasma exchange procedures to remove harmful antibodies. The study aims to collect and cryopreserve blood biospecimens, including plasma, serum, and PBMCs, for current and future research. Patients will be consented for participation shortly after being referred for plasma exchange, and the study will monitor antibody levels and BAFF levels in their blood throughout the treatment process. Importantly, participation will not alter the standard treatment plan for these patients.
Who should consider this trial
Good fit: Ideal candidates for this study are patients undergoing plasma exchange therapy for conditions like antibody-mediated rejection, NMO spectrum disorder, TTP, or CIDP.
Not a fit: Patients not undergoing plasma exchange therapy will not benefit from this study.
Why it matters
Potential benefit: If successful, this study could enhance understanding of antibody-mediated diseases and improve future treatment strategies.
How similar studies have performed: While this study is observational and focuses on biospecimen collection, similar studies have shown success in understanding immune-mediated diseases through plasma exchange.
Eligibility criteria
Show full inclusion / exclusion criteria
Pts undergoing plasma exchange therapy are eligible to be in this protocol
Where this trial is running
Iowa City, Iowa
- DeGowin blood Center — Iowa City, Iowa, United States (RECRUITING)
Study contacts
- Study coordinator: Charles Knudson, MD, PHD
- Email: c-knudson@uiowa.edu
- Phone: +1 319 467-5129
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Antibody-mediated Rejection, NMO Spectrum Disorder, TTP, CIDP, plasma exchange, plasmapheresis