Using metformin to improve blood vessel function in women after gestational diabetes

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This investigation aims to explore how metformin can enhance microvascular function in women who have experienced gestational diabetes mellitus (GDM). Women with a history of GDM are at an increased risk for cardiovascular disease, and this study seeks to understand the mechanisms behind persistent vascular dysfunction that can occur postpartum. By utilizing a minimally invasive technique to assess blood vessels in the skin, the researchers will evaluate the effectiveness of metformin compared to a placebo in improving vascular health. The findings could pave the way for new strategies to enhance cardiovascular outcomes in this population.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* ≥12 weeks and ≤5 years postpartum
* history of GDM or healthy pregnancy

Exclusion Criteria:

* prediabetes or diabetes (HbA1c ≥5.7%)
* current tobacco use
* cardiovascular or metabolic disease
* cardiovascular or metabolic medication
* history of hypertension during pregnancy
* current pregnancy

Where it's running

• University of Iowa
  Iowa City, Iowa, United States Recruiting

Study contacts

• Principal investigator: Anna Stanhewicz, PhD — University of Iowa
• Study coordinator: Anna Stanhewicz, PhD
• Email: anna-stanhewicz@uiowa.edu
• Phone: 3194671732

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Early Glucose Patterns in Pregnant Women at Risk for GDM

  This study tests whether continuous glucose monitoring in early pregnancy can detect dysglycemia before GDM is diagnosed, in women with and without known risk factors.

  Recruiting DCB Research AG · Bern, Canton of Bern · NCT07783178

• Probiotic-augmented therapy for gestational diabetes

  This trial tests whether adding multistrain probiotics to metformin, insulin, or their combination can improve blood sugar control and inflammation in pregnant women with gestational diabetes.

  Recruiting Riphah International University · Rawalpindi, Punjab Province · NCT07645001

• Maternal insulin and fat metabolism in pregnancies at risk for preeclampsia and gestational diabetes

  This project will try to see if insulin resistance and how the body burns fats early in pregnancy predict later preeclampsia or gestational diabetes in people at higher risk.

  Recruiting University of Tennessee Graduate School of Medicine · Knoxville, Tennessee · NCT07565727

• How sleep, lifestyle, and metabolism relate to pregnancy outcomes in gestational diabetes

  This project will see if sleep quality, anxiety, eating and activity habits, and metabolic markers relate to blood sugar control and birth outcomes in pregnant people with gestational diabetes.

  Recruiting University of Split, School of Medicine · Split · NCT07314944

• Pre-eclampsia risk in pregnancies after oocyte donation

  We will follow pregnant women who used donated eggs and women who used their own eggs to see if pregnancies after oocyte donation lead to a higher risk of pre-eclampsia.

  Recruiting at 6 sites Copenhagen University Hospital, Hvidovre · Copenhagen and 5 other locations · NCT07263490

• Mobile-based obstetric monitoring for hypertension and diabetes during pregnancy

  A mobile app-based program lets pregnant people with high blood pressure or gestational diabetes track BP and glucose at home and share results with their care team to guide care.

  Recruiting at 3 sites Rutgers, The State University of New Jersey · Biratnagar and 2 other locations · NCT07243886

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.