Effect of different root canal procedures on bacteria in infected teeth
Official title: Bacterial Reduction After Supplementary Disinfection Procedures in Infected Root Canals
Run by University of Iowa · NCT06569329 · Data updated 2026-11-12
This study is testing three different root canal treatments to see which one is best at reducing bacteria in infected teeth.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years to 95 Years |
| Sex | All |
| Enrollment | 90 (estimated) |
| Sponsor | University of Iowa Academic / other |
| Locations | 1 site (Iowa City, Iowa) |
| Status | Recruiting |
| Started | August 20, 2024 |
| Main results expected | August 2028 |
| Study ends | August 2028 |
| Registry record updated | September 10, 2026 |
| Trial ID | NCT06569329 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates for this study are adults aged 18 and older with teeth diagnosed with pulp necrosis and apical periodontitis.
✕Probably not a fit
Patients with vital pulp, incomplete root formation, or other specified dental conditions will not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This study investigates the impact of three distinct root canal procedures on bacterial levels in teeth diagnosed with dental pulp necrosis. A total of 90 adult participants will be recruited, with strict inclusion and exclusion criteria to ensure the selection of appropriate cases. The interventions include the GentleWave System, EdgePro Laser Therapy, and ProUltra Piezo Ultrasonic Therapy, with bacterial samples collected under aseptic conditions to assess the effectiveness of each method in reducing infection.
Why it matters
Potential benefit: If successful, this study could lead to improved root canal treatment outcomes by identifying the most effective disinfection procedures for infected teeth.
How similar studies have gone: While there have been studies on root canal procedures, this specific comparison of three different disinfection methods is relatively novel.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Diagnosis of pulp necrosis with apical periodontitis (AP) confirmed by pulp tests, clinical and radiographic evidence. * Tooth with no response to cold and electric pulp testing (done at screening). * Single canalled premolars with intact pulp chamber walls. * Patient must be 18 years of age or older Exclusion Criteria: * Teeth with vital pulp. * Teeth with incomplete root formation (immature with apical periodontitis). * Teeth with extensive crown destruction. * Teeth with previous endodontic treatment or intervention (pulp debridement). * Teeth with acute/ chronic apical abscess. * Teeth with internal or external resorption. * Teeth with non-odontogenic facial pain. * Teeth with periodontal pockets deeper than 4 mm. * Teeth with advanced untreated periodontal disease or recent periodontal surgery. * Teeth with mobility score greater than 2. * Teeth with a fracture or visible crack. * Patients with diabetes or immune compromised conditions. * Patients who received systemic antibiotics within the last 3 months. * Patients taking corticosteroids. * Patients who are pregnant.
Where it's running
-
University of Iowa College of Dentistry and Dental Clinics
Iowa City, Iowa, United States Recruiting
Study contacts
- Principal investigator: Abhishek Parolia, PhD, MDS — University of Iowa
- Study coordinator: Abhishek Parolia, PhD, MDS
- Email: abhishek-parolia@uiowa.edu
- Phone: (319) 335-7471
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.