Do adults who carry one cystic fibrosis gene have higher risk of heat-related dehydration and electrolyte problems?
Official title: Exploring a Common Genetic Risk Factor for Heat Stroke and Dehydration
Run by University of Iowa · NCT06847256 · Data updated 2026-11-12
This study will try to see if adults who carry one cystic fibrosis gene are more likely to get dehydrated or have electrolyte problems during heat exposure than similar adults without the gene.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years to 60 Years |
| Sex | All |
| Enrollment | 200 (estimated) |
| Sponsor | University of Iowa Academic / other |
| Locations | 1 site (Iowa City, Iowa) |
| Status | Recruiting |
| Started | November 19, 2025 |
| Main results expected | December 2026 |
| Study ends | December 2026 |
| Registry record updated | April 27, 2026 |
| Trial ID | NCT06847256 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults previously genotyped as CF carriers or as matched controls who can read and speak English and who meet the listed medical exclusion criteria are the ideal candidates.
✕Probably not a fit
People with known cystic fibrosis, diabetes, significant cardiovascular disease, current pregnancy, those taking beta blockers or diuretics, prisoners, or those unable to give consent are excluded and unlikely to benefit directly from participation.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
Researchers will use an observational, genotyped cohort to estimate the excess risk of fluid-and-electrolyte disorders associated with being a CF carrier. Aim 1 will enroll 100 CF carriers and 100 age- and sex-matched controls to complete a questionnaire about medical history, race/ethnicity, and heat-related experiences. Aim 2 will invite a subset of 25 carriers and 25 matched controls to an in-person visit to complete the same survey and undergo a controlled heat challenge in a sauna. Outcomes focus on reported heat responses and physiologic evidence of dehydration or electrolyte disturbance attributable to carrier status.
Why it matters
Potential benefit: If successful, the study could show that CF carrier status increases risk for heat-related dehydration and electrolyte problems, enabling targeted counseling and prevention for carriers.
How similar studies have gone: Some prior physiologic studies have suggested altered sweat and electrolyte handling in CF carriers, but controlled heat-challenge data in adults is limited, so this approach is relatively novel though grounded in earlier observations.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Previously genotyped as a CF carrier or control * Comfortable speaking/reading English Exclusion Criteria: * Previously genotyped as a CF patient * Diagnosis of Type 1 or Type 2 diabetes * History of heart attack, stroke, heart failure, or atherosclerosis * Currently pregnant * Currently taking beta blockers or diuretics * Prisoner status * Unable to provide own written informed consent
Where it's running
-
University of Iowa Health Care
Iowa City, Iowa, United States Recruiting
Study contacts
- Principal investigator: Aaron Miller, PhD — University of Iowa
- Study coordinator: Aaron Miller, PhD
- Email: aaron-miller@uiowa.edu
- Phone: (319) 335-3053
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.