Home blood pressure monitoring with pharmacist support for older adults with multiple chronic conditions
Improving High Blood Pressure in Older Adults Living With Multiple Chronic Diseases - The SMBP Study
This study will test whether home blood pressure monitoring combined with clinical pharmacist support lowers systolic blood pressure in people 65 and older who have multiple chronic conditions and uncontrolled hypertension.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 930 (estimated) |
| Ages | 65 Years and up |
| Sex | All |
| Sponsor | University of Iowa Academic / other |
| Drugs / interventions | chemotherapy, radiation |
| Locations | 2 sites (Iowa City, Iowa and 1 other locations) |
| Trial ID | NCT06932029 on ClinicalTrials.gov |
What this trial studies
This pragmatic, cluster-randomized trial compares self-measured blood pressure (SMBP) with conventional clinical support versus SMBP with clinical pharmacist support across primary care clinics. Clinics are randomized and eligible older adults (≥65) with sustained elevated systolic BP are enrolled and followed for 12 months, with the primary outcome being change in systolic blood pressure. The design uses broad inclusion criteria, EHR data collection, and minimal exclusions to maximize real-world generalizability. Secondary outcomes include self-reported treatment burden and planned subgroup analyses in rural and Black/African American older patients.
Who should consider this trial
Good fit: Ideal candidates are adults aged 65 or older with documented, sustained elevated systolic blood pressure, multiple chronic conditions, the ability to consent and communicate in English or Spanish, and plans to receive care at a participating health system.
Not a fit: Patients in hospice, living in nursing or skilled care facilities, unable to consent or communicate in English/Spanish, actively receiving cancer chemotherapy or radiation, pregnant, or with already controlled blood pressure are unlikely to benefit.
Why it matters
Potential benefit: If successful, this approach could help more older adults achieve lower systolic blood pressure and reduce their risk of stroke, heart attack, and kidney damage.
How similar studies have performed: Previous trials and quality-improvement programs have shown that SMBP and pharmacist-led medication management can improve blood pressure control, though this pragmatic trial focuses specifically on older adults with multiple chronic conditions.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * The patient is at least 65 years of age * Patient is seen at least once in clinic or healthcare system in the previous 12 months * Patient has a six-month average (non-acute/maintenance) systolic blood pressure (SBP) \>= 145 mmHg, documented in the electronic medical record in last six months * Patient has a baseline in-clinic visit systolic blood pressure (SBP) \>= 140 mmHg * Patient plants to receive care from participating healthcare system for the next 24 months Exclusion Criteria: * The patient is enrolled in hospice or has an active referral to hospice care * The patient resides in a nursing home, in skilled nursing, rehabilitation facility, or memory care * The patient is not capable of providing informed consent * The patient is unable to communicate in English or Spanish * The patient is in active chemotherapy or radiation treatment for cancer * The patient is pregnant or has plans to become pregnant * The patient is currently participating in another study focused on blood pressure * The patient does not have a telephone
Where this trial is running
Iowa City, Iowa and 1 other locations
- University of Iowa Health Care — Iowa City, Iowa, United States (Recruiting)
- University of Iowa — Iowa City, Iowa, United States (Not_yet_recruiting)
Study contacts
- Study coordinator: Korey Kennelty, PharmD, PhD
- Email: korey-kennelty@uiowa.edu
- Phone: 319-335-8862
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.