Investigating the impact of being a CF carrier on kidney and pancreatic health
Official title: The Effects of the CF Carrier State on the Kidneys and Pancreas
Run by University of Iowa · NCT05474417 · Data updated 2026-11-12
This study is trying to see if people who carry the cystic fibrosis gene are at a higher risk for kidney and pancreatic diseases compared to others.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years to 100 Years |
| Sex | All |
| Enrollment | 1250 (estimated) |
| Sponsor | University of Iowa Academic / other |
| Locations | 1 site (Iowa City, Iowa) |
| Status | Recruiting |
| Started | December 20, 2021 |
| Main results expected | December 2026 |
| Study ends | December 2026 |
| Registry record updated | September 4, 2026 |
| Trial ID | NCT05474417 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates include individuals identified as CF carriers through genetic testing and healthy controls without previous CF carrier test results.
✕Probably not a fit
Patients who are currently diagnosed with cystic fibrosis or those unable to provide informed consent may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational study aims to explore the potential increased risk of kidney and pancreatic diseases among individuals who are carriers of the cystic fibrosis (CF) gene compared to the general population. Participants will undergo a clinic visit where they will provide height, weight, blood pressure measurements, and blood samples. Additionally, a subset of participants will collect urine and stool samples at home for further laboratory analysis. The study seeks to identify subclinical evidence of these conditions in CF carriers through comprehensive testing and surveys.
Why it matters
Potential benefit: If successful, this study could lead to early detection and management strategies for kidney and pancreatic disorders in CF carriers.
How similar studies have gone: While the specific focus on CF carriers is novel, similar studies have indicated potential health risks associated with carrier states in other genetic conditions.
Who can join: the full rules
Show full inclusion / exclusion criteria
CF Carrier Inclusion Criteria: * A CF Carrier identified via genetic testing Control Inclusion Criteria: * No previous CF carrier test results Exclusion Criteria: * CF patient status * Unable to speak English * Currently pregnant * Unable to provide written informed consent * Prisoner status * Currently taking any medications for the treatment of diabetes
Where it's running
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University of Iowa Hospitals and Clinics
Iowa City, Iowa, United States Recruiting
Study contacts
- Principal investigator: Philip M Polgreen, MD — University of Iowa
- Study coordinator: Philip M Polgreen, MD
- Email: philip-polgreen@uiowa.edu
- Phone: (319) 384-6194
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.