Investigating oxidative stress and blood vessel function in women with a history of gestational diabetes
Role of Oxidative Stress in Microvascular Dysfunction Following Gestational Diabetes
This study is trying to see how oxidative stress affects blood vessel function in women who had gestational diabetes in the past five years.
Quick facts
| Phase | Early Phase 1 |
|---|---|
| Study type | Interventional |
| Enrollment | 28 (estimated) |
| Ages | 18 Years to 50 Years |
| Sex | Female |
| Sponsor | University of Iowa Academic / other |
| Locations | 1 site (Iowa City, Iowa) |
| Trial ID | NCT05946785 on ClinicalTrials.gov |
What this trial studies
This investigation aims to explore how oxidative stress contributes to microvascular dysfunction in women who have experienced gestational diabetes mellitus (GDM). The study focuses on women aged 18-50 who had GDM within the last five years, using a minimally invasive technique to assess blood vessel function in the skin. By measuring the response of blood vessels to specific agents, the researchers hope to uncover the mechanisms behind persistent vascular dysfunction following GDM. The findings could provide insights into cardiovascular disease risk in this population.
Who should consider this trial
Good fit: Ideal candidates are women aged 18-50 with a history of gestational diabetes diagnosed within the last five years.
Not a fit: Patients with current pregnancy, significant skin diseases, or metabolic disorders may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved understanding and management of cardiovascular disease risk in women with a history of gestational diabetes.
How similar studies have performed: While the association between gestational diabetes and cardiovascular risk is established, this specific investigation into oxidative stress and microvascular function is novel.
Eligibility criteria
Show full inclusion / exclusion criteria
INCLUSION CRITERIA: * female sex * 18 -50 years old * pregnancy history within 5 years of the study visit * had gestational diabetes diagnosed by their obstetrician and confirmed according to the American College of Obstetricians and Gynecologists criteria for gestational diabetes * or without a history of gestational diabetes EXCLUSION CRITERIA: * skin diseases * current tobacco/e-cigarette use * diagnosed or suspected hepatic or metabolic disease including diabetes * statin or other cholesterol-lowering medication * current antihypertensive medication * history of preeclampsia or gestational hypertension * current pregnancy * body mass index \<18.5 kg/m2 * allergy to materials used during the experiment.(e.g. latex), known allergies to study drugs.
Where this trial is running
Iowa City, Iowa
- University of Iowa — Iowa City, Iowa, United States (Recruiting)
Study contacts
- Study coordinator: Anna Reid-Stanhewicz, PHD
- Email: anna-stanhewicz@uiowa.edu
- Phone: 319-467-1732
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.