Investigating oxidative stress and blood vessel function in women with a history of gestational diabetes

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This investigation aims to explore how oxidative stress contributes to microvascular dysfunction in women who have experienced gestational diabetes mellitus (GDM). The study focuses on women aged 18-50 who had GDM within the last five years, using a minimally invasive technique to assess blood vessel function in the skin. By measuring the response of blood vessels to specific agents, the researchers hope to uncover the mechanisms behind persistent vascular dysfunction following GDM. The findings could provide insights into cardiovascular disease risk in this population.

Why it matters

Who can join: the full rules

INCLUSION CRITERIA:

* female sex
* 18 -50 years old
* pregnancy history within 5 years of the study visit
* had gestational diabetes diagnosed by their obstetrician and confirmed according to the American College of Obstetricians and Gynecologists criteria for gestational diabetes
* or without a history of gestational diabetes

EXCLUSION CRITERIA:

* skin diseases
* current tobacco/e-cigarette use
* diagnosed or suspected hepatic or metabolic disease including diabetes
* statin or other cholesterol-lowering medication
* current antihypertensive medication
* history of preeclampsia or gestational hypertension
* current pregnancy
* body mass index \<18.5 kg/m2
* allergy to materials used during the experiment.(e.g. latex), known allergies to study drugs.

Where it's running

• University of Iowa
  Iowa City, Iowa, United States Recruiting

Study contacts

• Study coordinator: Anna Reid-Stanhewicz, PHD
• Email: anna-stanhewicz@uiowa.edu
• Phone: 319-467-1732

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.