Post-filter hematocrit calculation for adults on continuous renal replacement therapy
Validation of a Post-Filter Hematocrit Calculation Formula: A Comparative Analysis With Measured Post-Filter Hematocrit Values
NA · University of Iowa · NCT07293936
This will test whether a calculation can accurately predict post-filter hematocrit compared with machine-measured values in adults receiving continuous renal replacement therapy.
Quick facts
| Phase | NA |
|---|---|
| Study type | Interventional |
| Enrollment | 20 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | University of Iowa (other) |
| Locations | 1 site (Iowa City, Iowa) |
| Trial ID | NCT07293936 on ClinicalTrials.gov |
What this trial studies
Filter clotting is a common complication of continuous renal replacement therapy (CRRT) that leads to blood loss, reduced treatment efficacy, and higher cost. This single-center validation compares a calculated post-filter hematocrit using the proposed formula HCTpost = HCTpre/(FF(HCTpre-1)+1) with directly measured post-filter hematocrit values from CRRT machines. Adult patients receiving CRRT (age ≥18) will be sampled, with patients on ECMO excluded, and paired calculated and measured values will be analyzed to determine agreement. The study is a cross-sectional diagnostic/method-comparison effort to determine whether the formula provides sufficiently accurate estimates for clinical use.
Who should consider this trial
Good fit: Adults aged 18 or older who are currently receiving CRRT at the enrolling center and are not on extracorporeal membrane oxygenation (ECMO).
Not a fit: Patients not receiving CRRT, those on ECMO, or individuals whose clinical condition prevents reliable blood sampling would not benefit from this validation.
Why it matters
Potential benefit: If accurate, the formula could allow clinicians to estimate post-filter hematocrit at the bedside and help guide filtration settings to reduce hemofilter clotting, blood loss, and treatment interruptions.
How similar studies have performed: Direct validation of post-filter hematocrit formulas is limited and the approach is relatively novel, with little prior evidence directly demonstrating clinical utility.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * patients initiated on CRRT age equal than or greater to 18 years of age Exclusion Criteria: * patients on ECMO
Where this trial is running
Iowa City, Iowa
- University of Iowa Hospitals and Clinics — Iowa City, Iowa, United States (RECRUITING)
Study contacts
- Study coordinator: Gwyndolyn M Radford, MD
- Email: gradford@uiowa.edu
- Phone: 7858179620
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Continuous Renal Replacement Therapy, Renal Failure, Hemofilter Clotting, crrt, continuous renal replacement therapy, hemofilter clotting, post-filter hematocrit, filtration fraction