New technology for assessing eye structure and function

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study investigates a novel non-invasive technology designed to evaluate the structure and function of the retina in patients with various optic neuropathies and retinopathies. By utilizing retinal imaging, the study aims to identify areas of abnormal structure and function in the retina, comparing these findings to traditional visual function tests. The intervention involves the use of LSFG-NAVI to gather detailed insights into retinal health and disease.

Why it matters

Who can join: the full rules

Controls:

Inclusion:

Normal eye exam in last 2 years

Exclusion:

Cataract or media opacity that would degrade the imaging of the retina. Mild cataracts are okay. Any abnormalities of the retina or optic nerve that could affect metabolism of the retina outside of normal.

Subjects with Inner Retina Defect:

Inclusion:

Defined structural defect to include those with Ischemic optic neuropathy, branch retinal artery occlusion (BRAO), hemianopia or visual field defect that respects the vertical meridian, inherited mitochondrial optic neuropathies such as Leber's and Dominant Optic Neuropathy, other retinopathies or optic neuropathies.

Exclusion:

Cataract or media opacity that would degrade the imaging of the retina. Mild cataracts are okay.

Subjects with Outer Retinal Defect:

Inclusion:

AZOOR (acute zonal occult outer retinopathy) or other focal or diffuse outer photoreceptor loss of function

Exclusion:

Cataract or media opacity that would degrade the imaging of the retina. Mild cataracts are okay.

The 450 total is to allow for exclusion of some subjects or in the event that the enrolled subject blinks too much or cannot fixate on a visual target adequately to maintain the same eye position during the short imaging interval. We hope to have a total of 450 (50 controls and 400 patients)

Where it's running

• University of Iowa Department of Ophthalmology
  Iowa City, Iowa, United States Recruiting

Study contacts

• Principal investigator: Randy H Kardon, MD, PhD — University of Iowa Department of Ophthalmology
• Study coordinator: Julie K Nellis, BSN
• Email: julie-nellis@uiowa.edu
• Phone: 319-356-8299

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.