Obesity and normal-weight healing after gum graft surgery using collagen plug or PRF

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

Adults undergoing gum graft surgery are grouped by weight status (obese vs. normal weight) and randomized to receive either a collagen plug or a platelet-rich fibrin (PRF) clot at the surgical site. The study tracks healing over up to 30 days across four follow-up visits, comparing the quantity and quality of healing material between the two interventions. It aims to see if obesity influences wound healing and whether PRF performs similarly to the standard collagen plug. Conducted at the University of Iowa, the trial provides insight into personalized healing approaches for dental procedures.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Be an adult who is undergoing any surgical procedure or volunteering to be part of the study
* Be able and willing to give informed consent on their own.
* Have good oral hygiene (keep their teeth and gums clean).
* Have a healthy roof of the mouth with no unusual shape, disease, or injury.
* Not have any active illness affecting their overall health.
* Not have a medical condition that can slow wound healing, such as uncontrolled type 2 diabetes.
* Not currently pregnant.
* Not have received a blood transfusion in the last 3 months.
* For normal-weight group (BMI less than than 30 kg/m2, waist circumference less than 35 inches for women or greater than 40 inches for men) or for obesity group (BMI greater than 30 kg/m2, waist circumference greater than 35 inches for women and greater than 40 inches for men).

Exclusion Criteria:

* Are unable or unwilling to provide your own informed consent.
* Take medications that may affect healing or require changes to the planned surgery.
* Have a history of alcohol or drug abuse.
* Currently smoke or have smoked in the past.
* Have had surgery before in the area where the current procedure will be performed.
* Have a history of an autoimmune disease or condition.

Where it's running

• University of Iowa College of Dentistry and Dental Clinics
  Iowa City, Iowa, United States Recruiting

Study contacts

• Principal investigator: Sukirth E Ganesan, DDS,PhD,MPH — University of Iowa College of Dentistry and Dental Clinics
• Study coordinator: Sukirth M Ganesan, DDS,PhD,MPH
• Email: sukirth-ganesan@uiowa.edu
• Phone: 319-467-1475

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.