Hand-soaking test to predict cystic fibrosis carrier status.
Official title: Using Aquagenic Wrinkling to Predict CF Carrier State
Run by University of Iowa · NCT06831110 · Data updated 2026-11-12
Try a hand-soaking test to see if it can identify people who carry the cystic fibrosis gene.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years to 24 Years |
| Sex | All |
| Enrollment | 2000 (estimated) |
| Sponsor | University of Iowa Academic / other |
| Locations | 1 site (Iowa City, Iowa) |
| Status | Recruiting |
| Started | March 6, 2025 |
| Main results expected | December 2026 |
| Study ends | December 2026 |
| Registry record updated | June 4, 2026 |
| Trial ID | NCT06831110 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are adults who can give written informed consent, are interested in CF carrier-related research, and do not have the listed hand conditions, diagnoses, or medications.
✕Probably not a fit
People with cystic fibrosis, prisoners, those unable to speak English or provide written consent, or those with open hand wounds, hand tattoos, missing portions of a hand, diabetes, hyperhidrosis, Raynaud's disease, atopic dermatitis, or who regularly take ACE inhibitors or ARBs are unlikely to benefit from participation.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This is an observational, single-visit study in which participants soak their hands in a water bath for up to 20 minutes to provoke aquagenic wrinkling. Investigators will document the timing and pattern of skin wrinkling and related observations. The study aims to determine whether the wrinkling response correlates with cystic fibrosis carrier status. The protocol excludes people with certain hand conditions, specific medical diagnoses, or medications that could affect results, and is conducted at a single center.
Why it matters
Potential benefit: If successful, this could provide a quick, low-cost screening tool to help identify cystic fibrosis carriers.
How similar studies have gone: Previous smaller studies have reported an association between aquagenic wrinkling and cystic fibrosis or carrier status, but the method is not yet validated as a screening test.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Interested in participating in other CF Carrier-related research studies. Exclusion Criteria: * CF patient status * Unable to speak English * Unable to provide written informed consent * Prisoner status * An open wound on either hand * A tattoo on either hand * Missing any portion of either hand * Diagnosis of Diabetes * Diagnosis of Hyperhidrosis * Diagnosis of Raynaud's Disease * Diagnosis of Atopic Dermatitis * Regularly taking ACE inhibitors or angiotensin receptor blockers
Where it's running
-
University of Iowa
Iowa City, Iowa, United States Recruiting
Study contacts
- Principal investigator: Philip M Polgreen, MD — University of Iowa
- Study coordinator: Philip M Polgreen, MD
- Email: philip-polgreen@uiowa.edu
- Phone: 319-384-6194
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
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Do adults who carry one cystic fibrosis gene have higher risk of heat-related dehydration and electrolyte problems?
This study will try to see if adults who carry one cystic fibrosis gene are more likely to get dehydrated or have electrolyte problems during heat exposure than similar adults without the gene.
-
Assessing respiratory infection risks in CF carriers
This study is testing if being a carrier of the CFTR gene mutation increases the risk of respiratory infections by comparing CF carriers with non-carriers.
-
Investigating the impact of being a CF carrier on kidney and pancreatic health
This study is trying to see if people who carry the cystic fibrosis gene are at a higher risk for kidney and pancreatic diseases compared to others.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.