Hand-soaking test to predict cystic fibrosis carrier status.
Using Aquagenic Wrinkling to Predict CF Carrier State
University of Iowa · NCT06831110
Try a hand-soaking test to see if it can identify people who carry the cystic fibrosis gene.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 2000 (estimated) |
| Ages | 18 Years to 24 Years |
| Sex | All |
| Sponsor | University of Iowa (other) |
| Locations | 1 site (Iowa City, Iowa) |
| Trial ID | NCT06831110 on ClinicalTrials.gov |
What this trial studies
This is an observational, single-visit study in which participants soak their hands in a water bath for up to 20 minutes to provoke aquagenic wrinkling. Investigators will document the timing and pattern of skin wrinkling and related observations. The study aims to determine whether the wrinkling response correlates with cystic fibrosis carrier status. The protocol excludes people with certain hand conditions, specific medical diagnoses, or medications that could affect results, and is conducted at a single center.
Who should consider this trial
Good fit: Ideal candidates are adults who can give written informed consent, are interested in CF carrier-related research, and do not have the listed hand conditions, diagnoses, or medications.
Not a fit: People with cystic fibrosis, prisoners, those unable to speak English or provide written consent, or those with open hand wounds, hand tattoos, missing portions of a hand, diabetes, hyperhidrosis, Raynaud's disease, atopic dermatitis, or who regularly take ACE inhibitors or ARBs are unlikely to benefit from participation.
Why it matters
Potential benefit: If successful, this could provide a quick, low-cost screening tool to help identify cystic fibrosis carriers.
How similar studies have performed: Previous smaller studies have reported an association between aquagenic wrinkling and cystic fibrosis or carrier status, but the method is not yet validated as a screening test.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Interested in participating in other CF Carrier-related research studies. Exclusion Criteria: * CF patient status * Unable to speak English * Unable to provide written informed consent * Prisoner status * An open wound on either hand * A tattoo on either hand * Missing any portion of either hand * Diagnosis of Diabetes * Diagnosis of Hyperhidrosis * Diagnosis of Raynaud's Disease * Diagnosis of Atopic Dermatitis * Regularly taking ACE inhibitors or angiotensin receptor blockers
Where this trial is running
Iowa City, Iowa
- University of Iowa — Iowa City, Iowa, United States (RECRUITING)
Study contacts
- Principal investigator: Philip M Polgreen, MD — University of Iowa
- Study coordinator: Philip M Polgreen, MD
- Email: philip-polgreen@uiowa.edu
- Phone: 319-384-6194
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Aquagenic Wrinkling of Palms, Carrier State