Examining how e-cigarette use affects blood vessels differently in men and women

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study investigates the vascular effects of e-cigarette use, focusing on potential sex differences in response to vaping. Participants aged 18-24 will either be current e-cigarette users or individuals with no history of e-cigarette use. The study will utilize local heating and a nitric oxide synthase inhibitor, L-NAME, alongside chronic estrogen exposure to assess vascular function. The goal is to better understand the cardiovascular implications of e-cigarette use among young adults, a demographic with increasing prevalence of vaping.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* 18-24 years old
* one of the following:

  1. have no history of e-cigarette use
  2. be a current e-cigarette user who has been using e-cigarettes for 6 months or longer

Exclusion Criteria:

* history of cardiovascular, metabolic, and/or skin diseases
* body mass index \>30 kg/m2
* blood pressure ≥140 systolic and/or ≥ 90 diastolic
* current or history of tobacco cigarette use
* current antihypertensive or cholesterol-lowering medication
* current use of cannabis, marijuana, and/or other illegal substances
* current use of stimulant drugs
* currently pregnant or breastfeeding
* allergy to materials used during the experiment (e.g. latex),
* known allergy to study drugs
* healthy control subjects will also be excluded if they have ever used e-cigarettes in the past

Where it's running

• University of Iowa
  Iowa City, Iowa, United States Recruiting

Study contacts

• Study coordinator: Anna Reid-Stanhewicz, PHD
• Email: anna-stanhewicz@uiowa.edu
• Phone: 319-467-1732

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.