Examining how e-cigarette use affects blood vessels differently in men and women
Sex Differences in the Vascular Effects of E-cigarette Use
This study is testing how using e-cigarettes affects blood vessels in young men and women to see if there are any differences in their responses.
Quick facts
| Phase | Early Phase 1 |
|---|---|
| Study type | Interventional |
| Enrollment | 80 (estimated) |
| Ages | 18 Years to 24 Years |
| Sex | All |
| Sponsor | University of Iowa Academic / other |
| Locations | 1 site (Iowa City, Iowa) |
| Trial ID | NCT06159608 on ClinicalTrials.gov |
What this trial studies
This study investigates the vascular effects of e-cigarette use, focusing on potential sex differences in response to vaping. Participants aged 18-24 will either be current e-cigarette users or individuals with no history of e-cigarette use. The study will utilize local heating and a nitric oxide synthase inhibitor, L-NAME, alongside chronic estrogen exposure to assess vascular function. The goal is to better understand the cardiovascular implications of e-cigarette use among young adults, a demographic with increasing prevalence of vaping.
Who should consider this trial
Good fit: Ideal candidates are young adults aged 18-24 who are either current e-cigarette users or have never used e-cigarettes.
Not a fit: Patients with a history of cardiovascular or metabolic diseases, or those who have ever used tobacco cigarettes, will not benefit from this study.
Why it matters
Potential benefit: If successful, this study could provide insights into the cardiovascular risks associated with e-cigarette use, potentially guiding safer vaping practices.
How similar studies have performed: While there is limited research on the cardiovascular effects of e-cigarettes, this study aims to fill a gap in understanding sex differences, making it a novel approach.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * 18-24 years old * one of the following: 1. have no history of e-cigarette use 2. be a current e-cigarette user who has been using e-cigarettes for 6 months or longer Exclusion Criteria: * history of cardiovascular, metabolic, and/or skin diseases * body mass index \>30 kg/m2 * blood pressure ≥140 systolic and/or ≥ 90 diastolic * current or history of tobacco cigarette use * current antihypertensive or cholesterol-lowering medication * current use of cannabis, marijuana, and/or other illegal substances * current use of stimulant drugs * currently pregnant or breastfeeding * allergy to materials used during the experiment (e.g. latex), * known allergy to study drugs * healthy control subjects will also be excluded if they have ever used e-cigarettes in the past
Where this trial is running
Iowa City, Iowa
- University of Iowa — Iowa City, Iowa, United States (Recruiting)
Study contacts
- Study coordinator: Anna Reid-Stanhewicz, PHD
- Email: anna-stanhewicz@uiowa.edu
- Phone: 319-467-1732
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.