Role of IRS2 in heart calcium balance and arrhythmia risk
Official title: Elucidating the role of IRS2 in cardiac Ca2+ homeostasis and arrhythmogenesis
Funded at University of Iowa · NIH-11448567 · Data updated 2026-11-12
Aims to find out how IRS2 helps keep heart calcium steady and prevent dangerous rhythms after a heart attack.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Iowa NIH-funded |
| Lab location | 1 site (Iowa City, United States) |
| Project start | September 1, 2026 |
| Project end | May 31, 2031 |
| Funding year | 2026 |
| Award (this year) | $743,341 |
| NIH project number | 1R01HL175047-01A1 |
| Project ID | NIH-11448567 on NIH RePORTER |
Who could benefit from this research
✓Could help
Patients who have had a myocardial infarction or are at high risk for post-MI arrhythmias may benefit from future therapies emerging from this work.
✕Less likely to help
Individuals without heart disease or post-MI risk may not directly benefit from this research.
What this research studies
This project explores how insulin receptor substrate 2 (IRS2) helps cardiomyocytes manage calcium during sympathetic stress, with a focus on preventing ventricular arrhythmias after myocardial infarction. By studying IRS2’s phosphorylation and its effect on beta-adrenergic receptor signaling, researchers hope to identify a targeted way to reduce arrhythmia risk without bluntly blocking normal heart function. The study combines human and mouse data to confirm IRS2’s protective role and to understand how its activity could be leveraged for safer therapies. If successful, findings could guide the development of new treatments that specifically curb arrhythmogenic signaling in the heart.
Why it matters
Potential benefit: Possibly leads to targeted therapies that reduce sudden cardiac death risk by stabilizing heart calcium signaling.
How similar studies have gone: Previous work suggests IRS2 plays a protective role in heart stress, supporting potential for new targeted therapies.
Where this research is happening
-
University of Iowa
Iowa City, United States Active
Researchers
- Principal investigator: Shi, Qian — University of Iowa
- Study coordinator: Shi, Qian
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.